Successful Treatment of Nodular Actinic Reticuloid with Tacrolimus Ointment

Gröne, Dirk H.; Kunz, Manfred; Zimmermann, R.; Gross, Gerd

doi:10.1159/000092291

Cited by 12 publications

(3 citation statements)

References 35 publications

(36 reference statements)

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“…Treatment of CAD is often difficult. However, avoidance of ultraviolet radiation exposure, and the oral administration of steroids are sometimes effective for CAD 6 . In our case, the skin lesion was severe in the dorsal aspect of the hand, although no other sun‐exposed regions were affected.…”

mentioning

confidence: 63%

Case of keratosis lichenoides chronica

Tsuboi

Katsuoka

2007

The Journal of Dermatology

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It has been reported that the presence of lichenoid papules, linear keratotic ridges and erythemotosquamous plaques are essential for making a diagnosis of KLC. 4 Seventy-five percent of KLC patients have facial lesions which resemble either seborrhea-like dermatitis or rosacea and such facial lesions are helpful for making a diagnosis of KLC. The oral cavity, palms, soles, finger, toe and nails are sometimes affected. Histologically, many cases of KLC show acanthosis and hyperkeratosis with focal parakeratosis, a band-like lymphocyte infiltrate in the upper dermis, which is associated with focal vacuolization of the basal layer. 5 We herein describe a 69-year-old male with KLC who was treated by cyclosporin, electron beam therapy and etoposide with some effectiveness.A 69-year-old male presented with erythema on the face, the back of his hands, extremities and trunk from 1 year prior. He underwent medical examination and was referred to the department of dermatology of our hospital. A skin examination revealed a bean-sized erythema with hyperkeratosis which were red in color, demonstrated an irregular margin and were scattered over the extremities and trunk (Fig. 1a). They tended to stick to each other and were arranged in a reticular pattern. On the back of his hands, the erythema was slightly elevated with severe scaling. Linear keratotic ridge was seen on the back of his finger. A maculopapular erythema was observed with desquamation on the nose, perioral area and the lips (Fig. 1b). In addition,

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mentioning

confidence: 63%

Case of keratosis lichenoides chronica

Tsuboi

Katsuoka

2007

The Journal of Dermatology

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“…En caso de que se identifiquen alérgenos de contacto o de contacto con la luz solar, se deben evitar 59 . Como tratamiento de primera línea se usan los esteroides tópicos de mediana o alta potencia, o inhibidores tópicos de la calcineurina [67][68][69] . Para la enfermedad generalizada o resistente al tratamiento, se usan medicamentos inmunosupresores.…”

Section: Tratamientounclassified

Fotodermatosis mediadas inmunológicamente

Mariaca¹,

Núñez²

2016

rev. asoc. colomb. dermatol. cir. dematol.

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Las fotodermatosis son enfermedades de la piel inducidas o exacerbadas por la radiación electromagnética (radiación ultravioleta, luz visible) y se pueden dividir en cinco grupos: fotodermatosis mediadas inmunológicamente, fotodermatosis secundarias a agentes exógenos, fotodermatosis secundarias a agentes endógenos y enfermedades causadas por defecto en la reparación del ADN (genodermatosis). En este artículo, se revisa el primer grupo de fotodermatosis, las cuales incluyen la erupción solar polimorfa, el prurigo actínico, la dermatitis actínica crónica, la urticaria solar y la hidroa vacciniforme.

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“…There are a few case reports of successful treatments, including resistant lesions of CAD. This beneficial effect may be attributed to the fact that CAD is characterized by a lymphohistiocytic infiltrate producing a chronic eczema and that tacrolimus blocks the activation of lymphocytes and other immune system cells, also inhibiting the release of mediators from cutaneous mast cells and basophils 24 …”

Section: Contact Hypersensitivitymentioning

confidence: 99%

Tacrolimus: Approved and Unapproved Dermatologic Indications/Uses—Physician's Sequential Literature Survey: Part II

Sehgal¹,

Srivastava²,

Dogra³

2008

Skinmed

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Tacrolimus has been a useful therapeutic tool in dermatology practice ever since its inception. Accordingly, many "off-label" applications have been reported. Thus, its local immunosuppressive and steroid-sparing action stands recognized. Hence, its indications/uses were extended beyond atopic dermatitis to cover several dermatoses including other types of eczema, papulosquamous disorder of cornification, rosacea, other inflammatory skin conditions, vesicobullous disease, connective tissue disease, graft versus host disease, and follicular disorders. Many such diseases found to respond to tacrolimus therapy have been briefly recounted. It is worthwhile to conceive, however, that this topical immunomodulator should be reserved for use only as an alternative, should the conventional treatment be unresponsive. Hence, guarded use is warranted.

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Successful Treatment of Nodular Actinic Reticuloid with Tacrolimus Ointment

Cited by 12 publications

References 35 publications

Case of keratosis lichenoides chronica

Case of keratosis lichenoides chronica

Fotodermatosis mediadas inmunológicamente

Tacrolimus: Approved and Unapproved Dermatologic Indications/Uses—Physician's Sequential Literature Survey: Part II

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