Successful treatment of mixed yolk sac tumor and mature teratoma in the spinal cord: case report

Mukasa, Akitake; Yanagisawa, Shunsuke; Tanaka, Shota; Takai, Keisuke; Shibahara, Junji; Ikegami, Masachika; Nakao, Yusuke; Takeshita, Katsushi; Matsutani, Masao; Saito, Nobuhito

doi:10.3171/2016.8.spine16465

Cited by 8 publications

(7 citation statements)

References 20 publications

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“…3 Less than 50 cases of primary spinal GCTs have been described worldwide, with only 2 cases being NG-GCT (AFP secreting) (localized; both in adults). 4 Our report of an atypical presentation of an intradural, extramedullary tumor with cranial dissemination in a childhood NG-GCT has not been described in the literature.…”

Section: Discussionmentioning

confidence: 74%

A Primary Spinal Nongerminomatous Germ Cell Tumor With Multiple Intracranial Metastases in a Toddler

Ramanathan¹,

Hill

Ryles

et al. 2022

Journal of Pediatric Hematology/Oncology

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Central nervous system germ cell tumors (CNS-GCTs) comprise 4% of all pediatric CNS tumors, with one third being nongerminomatous GCT (CNS-NG-GCT) type. The majority of these tumors arise in the intracranial compartment with 20% having drop metastases in the spine. We present a rare case of a 2-year-old boy with a primary intradural-extramedullary NG-GCT arising from the lumbosacral spine with a trifecta of unfavorable features, that is, young age, alpha-feto protein >1000 ng/mL, and disseminated disease within the cranium. Owing to his young age, he was treated with chemotherapy alone, avoiding radiation. His tumor marker (alpha-feto protein) declined from 8468 to 10 k-U/L over 8 weeks, and he remained in remission at the last follow-up. This atypical presentation of an intradural-extramedullary tumor with cranial dissemination in a childhood NG-GCT has yet to be described in the literature. Here we use this opportunity to highlight the treatment strategies and challenges in this unique clinical case.

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Section: Discussionmentioning

confidence: 74%

A Primary Spinal Nongerminomatous Germ Cell Tumor With Multiple Intracranial Metastases in a Toddler

Ramanathan¹,

Hill

Ryles

et al. 2022

Journal of Pediatric Hematology/Oncology

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“…Similarly, other case studies report histopathological findings such as numerous fatty cysts consisting of neuroepithelial and epithelial tissues, nerve cells, specialized structures resembling Pacini's corpuscles, ganglion cells and Rosenthal cells, cutaneous elements, focal calcifications, thyroid follicles, and carcinoid features. Thus from this, it is inferable that a teratoma diagnosis should be suspected whenever structures derived from one or more germ layers are present in the biopsy [ 12 , 28 , 35 , 36 ]. Some immunohistochemical markers could improve diagnostic accuracy, these include mainly SALL4, AFP, and b-HCG reported by Mukasa in 2017 [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Mature Teratoma at the Lumbar Spinal Cord: A Case Report and Literature Review

Zavala-Romero,

Villanueva-Castro,

Datta-Banik

et al. 2024

Cureus

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Mature spinal teratoma is a rare type of germ cell tumor that arises from any of the three germ cell layers (ectoderm, mesoderm, and endoderm) and consists of differentiated tissues and structures that reflect the cellular organization and morphology of normal adult tissues. It has the ability to grow independently and cause compressive symptoms when found in this rare location. In this article, we present the case of a 29-year-old male patient with the onset of neurological symptoms beginning with pelvic limb paresthesias and progressing to back pain. Magnetic resonance imaging (MRI) revealed a tumor at L1-L4, which was resected by laminotomy, and histopathology revealed a mature intradural teratoma. Fortunately, this histologic type had a good prognosis for our patient, who had a significant clinical improvement. A systematic review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology with PubMed and Google Scholar to find similar case reports and to summarize the main features of this disease, which contributes to the understanding of its diagnostic presentation, treatment, and prognosis, improving clinical practice in the management of similar cases. The rarity of this condition, together with its wide clinical heterogeneity and prognosis, underscores the importance of a thorough evaluation of cases of intramedullary lesions, where the consideration of uncommon diseases in the differential diagnosis should be highlighted.

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“…Then we searched with multiple or multifocal for all fields between these reports, with just 15 reports left. After screening the abstract, we found 2 cases that reported multiple intracranial yolk sac tumors ( 17 , 18 ). We have collected these patients' clinical features, including the present case in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

Multifocal primary intracranial yolk sac tumor in an adult patient: a case report and literature review

Yang¹,

Wang²,

Chen³

et al. 2022

Transl Cancer Res TCR

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Background Yolk sac tumor is a type of germ cell tumor. It commonly arises in the gonads but sometimes can occur outside the gonads. Primary intracranial yolk sac tumors were very rare. It is always located in the pineal, suprasellar and posterior third ventricular region. The incidence of yolk sac tumor is estimated as less than 8% of all primary intracranial germ cell tumors. Multifocal primary intracranial yolk sac tumors have seldom been reported. Case Description Here we reported a 29 years old male patient with a sudden coma and a history of headaches for one month. Computed Tomography and magnetic resonance imaging of the head showed three masses located at the suprasellar region, pineal region and left temporal lobe separately. The mass at the left temporal lobe was successfully resected with emergency surgery, and decompressive craniectomy was also performed. Intraoperative findings revealed that the tumor was a solid mass with intra-tumoral haemorrhage. The pathology examination confirmed the diagnosis of yolk sac tumor. Hematoxylin and eosin staining clearly showed the Schiller-Duval body. Whole-brain radiotherapy was performed after the operation, and the patient died in a local hospital 11 months after the surgery. Conclusions We reported a case of multifocal primary intracranial yolk sac tumor in an adult patient. Then we reviewed the literature and discussed the treatment and diagnosis of patients with primary intracranial yolk sac tumors.

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Successful treatment of mixed yolk sac tumor and mature teratoma in the spinal cord: case report

Cited by 8 publications

References 20 publications

A Primary Spinal Nongerminomatous Germ Cell Tumor With Multiple Intracranial Metastases in a Toddler

A Primary Spinal Nongerminomatous Germ Cell Tumor With Multiple Intracranial Metastases in a Toddler

Mature Teratoma at the Lumbar Spinal Cord: A Case Report and Literature Review

Multifocal primary intracranial yolk sac tumor in an adult patient: a case report and literature review

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