Successful Treatment of Lymphadenosis benigna cutis with Topical Photodynamic Therapy with Delta-Aminolevulinic Acid

Takeda, Hitoshi; Kaneko, Takahide; Harada, Ken; Matsuzaki, Yasushi; Nakano, Hajime; Hanada, Katsumi

doi:10.1159/000087021

Cited by 24 publications

(18 citation statements)

References 31 publications

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“…Photodynamic therapy (PDT) is increasingly used in the treatment of various skin diseases such as actinic keratosis, non-melanoma skin cancer, Bowen disease, acne, rosacea or lymphadenosis benigna cutis [1,2,3,4]. Compared to traditional treatment, such as curettage, cryotherapy or surgery, PDT often offers less morbidity and a superior cosmetic result.…”

Section: Introductionmentioning

confidence: 99%

Pain and Photodynamic Therapy

Lindeburg¹,

Brogaard²,

Jemec³

2007

Dermatology

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Background: Photodynamic therapy (PDT) is increasingly used in the treatment of various skin diseases. The main adverse effect in PDT treatment is pain. Each lesion is generally treated twice, and clinical experience suggests that the 2nd treatment causes more pain than the 1st and thus becomes a therapy-limiting factor. Objectives: To investigate the intrapatient variation in the experience of pain, between 1st and 2nd PDT treatments. Methods: We registered patients treated with PDT by using a mechanical visual analogue scale (VAS). Patients were tested immediately after the 1st and 2nd PDT treatments. Intrapatient comparison was made comparing 1st and 2nd treatments. Results: A total of 38 patients were included. The median VAS score increased significantly according to the Wilcoxon matched-pairs signed-ranks test (p < 0.02) from 4 after the 1st PDT (range 0–8) to 4.75 (range 1–10) after the 2nd PDT treatment. The VAS score of pain was increased in the 2nd treatment for 21 patients, remained unchanged in 6 patients and was reduced in 11 patients who reported less pain after the 2nd treatment. Patients who scored low (VAS <5) after the 1st treatment experienced an increase in mean VAS score of 1.4 at the 2nd PDT treatment. In contrast, subjects with a high VAS score (>5) after the 1st PDT had a mean decrease in the VAS score of 0.26 at the 2nd PDT treatment. The difference (p = 0.005) suggests that the pain at the 1st PDT treatment may be predictive of future pain. Conclusion: The 2nd treatment of PDT was significantly more painful than the 1st, although some patients experienced reduced pain on the 2nd treatment. The pain experienced at the 1st PDT treatment may be predictive of the pain at subsequent treatments.

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Section: Introductionmentioning

confidence: 99%

Pain and Photodynamic Therapy

Lindeburg¹,

Brogaard²,

Jemec³

2007

Dermatology

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“…Lymphocytoma cutis, traditionally caused by B. burgdorferi , responds to cyclosporin therapy, as do some of the idiopathic varieties. Glucocorticosteriods (topical, intra lesional 5-40 mg/mL 1 mL monthly or systemic 60/40/20 mg 5 days each tapered), hydroxychloroquine 200 mg twice daily, and minocycline 50-100 mg twice daily have been used in the past with varied success4. Some studies also support the use of HIV antiviral triple therapy5 or topical tacrolimus6.…”

Section: Discussionmentioning

confidence: 99%

Lymphocytoma cutis: diagnostic enigma for the maxillofacial surgeon

Kale

Singh

Shah

2016

J Korean Assoc Oral Maxillofac Surg

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Cutaneous lymphoid hyperplasia (CLH) is a cutaneous pseudolymphoma with a worldwide distribution, equally affecting all races and ethnic groups. Due to its vast array of characteristics, it is most often missed in the differential diagnosis of firm to soft lumps on the head and neck. A systematic approach to the workup and diagnosis along with treatment of such lesions is discussed in this article. A 20-year-old Asian Indian female presented to our Oral and Maxillofacial unit with a lump on the left side of her forehead for 1 month. Local examination revealed a 2.5×3.0 cm2, well circumscribed swelling over the left para median region that was firm to doughy and non-tender. There was no other significant finding on general examination. Excisional biopsy of the lesion was performed, followed by histopathologic processing. The general etiology, pathogenesis, clinical presentation, differential diagnosis, clinical course, prognosis, treatment, and prevention have been discussed in line with the recent modalities of diagnosis and treatment of CLH. Due to the overlapping clinical and histological characteristics of CLH with many other lesions, it is important to consider this lesion in the differential diagnosis of cutaneous lesions.

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“…MAL-PDT is an established non-surgical treatment of cutaneous precancerous lesions and skin cancer. Recent studies suggest a possible immunomodulating effect of PDT [2,3,4,5,6,7]. Topically applied MAL sensitizes mainly keratinocytes.…”

Section: Discussionmentioning

confidence: 99%

Generalized Granuloma Annulare Treated with Methylaminolevulinate Photodynamic Therapy

et al. 2009

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Granuloma annulare (GA) is a non-infectious granulomatous dermatosis characterized by annular papules and rarely nodules and plaques, arising on the dorsa of the hands, feet, elbows and knees; it is usually chronic and asymptomatic. The aetiology of GA is unknown, although many hypotheses have been postulated. About 10% of patients affected by GA present the generalized subtype, characterized by a later age of onset and a chronic course with a low tendency to spontaneous resolution. The widespread papular eruption develops on the trunk and upper or lower limbs. Generalized GA is very disfiguring because of the extensive dissemination of the lesions. The response to various treatments, namely topical and intralesional corticosteroids, topical tacrolimus, dapsone, isotretinoin, etretinate or hydroxychloroquine, is usually unsatisfactory. We report 3 cases with long-lasting generalized GA responding to methylaminolevulinate photodynamic therapy.

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Successful Treatment of Lymphadenosis benigna cutis with Topical Photodynamic Therapy with Delta-Aminolevulinic Acid

Cited by 24 publications

References 31 publications

Pain and Photodynamic Therapy

Pain and Photodynamic Therapy

Lymphocytoma cutis: diagnostic enigma for the maxillofacial surgeon

Generalized Granuloma Annulare Treated with Methylaminolevulinate Photodynamic Therapy

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