Successful Treatment of Lupoid Cutaneous Leishmaniasis with Glucantime and Topical Trichloroacetic Acid (A Case Report)

Nilforoushzadeh, Mohammad Ali; Sadeghian, G; Jaffary, Fariba; Ziaei, Hengameh; Shirani-Bidabad, Liela; Mahzoni, Parvin

doi:10.3347/kjp.2008.46.3.175

Cited by 8 publications

(9 citation statements)

References 16 publications

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“…Others have also demonstrated the benefits of sequential combined administration of allopurinol and benznidazole in human chronic disease, which leads to changes in T and B immune responses indicative of beneficial therapeutic outcomes (29). Similarly, an improvement in the treatment of cutaneous leishmaniasis also has been observed when allopurinol was given in combination with antimony compounds (30, 31) or trichloroacetic acid (32). Rial et al (33) evaluated the effect of the allopurinol combined with benznidazole in C3H/HeN and C57BL/6J mice with T.…”

Section: Introductionmentioning

confidence: 86%

Synergic Effect of Allopurinol in Combination with Nitroheterocyclic Compounds against Trypanosoma cruzi

Mazzeti

Diniz

Gonçalves

et al. 2019

Antimicrob Agents Chemother

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Combination therapy has gained attention as a possible strategy for overcoming the limitations of the present therapeutic arsenal for Chagas disease. The aim of this study was to evaluate the effect of allopurinol in association with nitroheterocyclic compounds on infection with the Y strain of Trypanosoma cruzi. The in vitro effect of allopurinol plus benznidazole or nifurtimox on intracellular amastigotes in infected H9c2 cells was assessed in a 72-h assay. The interactions were classified as synergic for both allopurinol-nifurtimox (sums of fractional inhibitory concentrations [∑FICs] = 0.49 ± 0.08) and allopurinol-benznidazole (∑FICs = 0.48 ± 0.09). In the next step, infected Swiss mice were treated with allopurinol at 30, 60, and 90 mg/kg of body weight and with benznidazole at 25, 50, and 75 mg/kg in monotherapy and in combination at the same doses; as a reference treatment, another group of animals received benznidazole at 100 mg/kg. Allopurinol in monotherapy led to a smaller or nil effect in the reduction of parasite load and mortality rate. Treatment with benznidazole at suboptimal doses induced a transient suppression of parasitaemia with subsequent relapse in all animals treated with 25 and 50 mg/kg and in 80% of those that received 75 mg/kg. Administration of the drugs in combination significantly increased the cure rate to 60 to 100% among mice treated with benznidazole at 75 mg/kg plus 30, 60, or 90 mg/kg of allopurinol. These results show a positive interaction between allopurinol and benznidazole, and since both drugs are commercially available, their use in combination may be considered for the assessment in the treatment of Chagas disease patients.

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Section: Introductionmentioning

confidence: 86%

Synergic Effect of Allopurinol in Combination with Nitroheterocyclic Compounds against Trypanosoma cruzi

Mazzeti

Diniz

Gonçalves

et al. 2019

Antimicrob Agents Chemother

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“…13 They reported 13 Nilforoushzadeh and colleagues evaluated intralesional MA and TCA in the treatment of patients with acute CL. 14 They found that after 6 weeks, 68% and 65.7% of patients in the TCA and MA groups, respectively, experienced complete clinical cure.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, several physical therapeutic methods are available, including CO 2 laser, cryotherapy, thermotherapy, and trichloroacetic acid (TCA). [9][10][11][12][13][14] Accordingly, consideration of new local treatment methods with fewer side effects is preferred. TCA is a caustic and hemostatic material.…”

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confidence: 99%

Comparison of Lesion Improvement in Lupoid Leishmaniasis Patients with Two Treatment Approaches

et al. 2015

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“…A lupoid leishmaniasis, a particular form of cutaneous Leishmania infection, common in the Middle East and Afghanistan, mainly caused by Leishmania tropica , and typically resistant to the common therapies, was excluded thanks to the histological findings (3).…”

Section: Case Reportmentioning

confidence: 99%

Discoid chronic lupus erythematosus at the site of a previously healed cutaneous leishmaniasis: an example of isotopic response

Bardazzi

Giacomini

Savoia

et al. 2010

Dermatologic Therapy

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The term "isotopic response" describes the occurrence of a new skin disorder at the site of another, unrelated and already healed one. We report here the case of a 38-year-old woman who referred to us for an infiltrated, red-brownish plaque localized on her left cheek. The patient had been treated for a cutaneous leishmaniasis, confirmed by the histologic examination, localized at the same site. She was completely healed after an appropriate local and systemic treatment. She experienced the occurrence of the new plaque at the site of the previously healed cutaneous leishmaniasis three month later. Histologic examination and laboratory tests were consistent with a diagnosis of discoid cutaneous chronic lupus erythematosus. Treatment with hydroxychloroquine, topical clobetasol and topical tretinoin resulted in flattening and clearing of the lesion. Our case is the first case of isotopic response where a discoid chronic lupus erythematosus had occurred at the site of an already healed cutaneous leishmaniasis. We speculate that the activation of type-1 interferon system may be involved in the pathogenesis of our case.

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Successful Treatment of Lupoid Cutaneous Leishmaniasis with Glucantime and Topical Trichloroacetic Acid (A Case Report)

Cited by 8 publications

References 16 publications

Synergic Effect of Allopurinol in Combination with Nitroheterocyclic Compounds against Trypanosoma cruzi

Synergic Effect of Allopurinol in Combination with Nitroheterocyclic Compounds against Trypanosoma cruzi

Comparison of Lesion Improvement in Lupoid Leishmaniasis Patients with Two Treatment Approaches

Discoid chronic lupus erythematosus at the site of a previously healed cutaneous leishmaniasis: an example of isotopic response

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