Successful treatment of lung adenocarcinoma in an 18-year-old man

Abstract

Primary lung cancer is an extremely rare neoplasm in young adults. We report a case of a primary lung adenocarcinoma in an 18-year-old man who presented for examination of a solitary nodule located in the right lower lobe of the lung. A right lower lobectomy was performed with an incomplete resection because of pleural dissemination (pT4N2M0 stage IIIB adenocarcinoma). Intrathoracic chemotherapy (cisplatin, 50 mg/body) was administered initially, followed by systemic chemotherapy (carboplatin + paclitaxel). A bronchopleural fistula occurred 2 months postoperatively and was successfully treated with conservative therapy, including thoracic drainage, intrathoracic fibrin glue administration, and transbronchial superglue administration. Thereafter, a total of five courses of systemic chemotherapy with minor changes in the administration regimen were performed. The patient was alive and with no evidence of recurrence at his 5-year follow-up.

Adenocarcinoma of the Lung in Childhood and Adolescence: A Systematic Review

“…18 EGFR mutations are more common in Asian, female, and older (nonpediatric) patients, and no patients in our review were EGFR-mutation-positive. 33 When we consider the 24 cases reported after 2007 (the year the association between ALK rearrangement and NSCLC was first described), we found two cases were ALK-positive and one was ROS-positive. 65 These mutations are now targetabledrugs including crizotinib, ceritinib, and 57 17 M 0 Surgery Disease free (3 mo) Granata 1998 58 11 M 0 Surgery Disease free (18 mo) Ohye 1998 59 6 M IVA Surgery Disease free (7 y) Ohye 1998 59 15 F 0 Surgery Disease free (4 y) Kaslovsky 1997 60 11 F IVA Surgery Disease free Dosanjh 1992 61 15 F IVA Nil Lost to follow-up Sheffield 1987 62 6 mo M -Surgery Not stated Sheffield 1987 62 3 F -Surgery Not stated Sheffield 1987 62 18 M -Surgery Not stated Brody 1976 63 15 M 0 Surgery Disease free (2 mo) Gardner 1972 64 17 M IVB Nil Died from disease (autopsy diagnosis)…”

Two Cases of Single-Stage Closure of a Bronchopleural Fistula Using Latissimus Dorsi Musculocutaneous Flaps after Lung Surgery

“…A BPF after segmental or pulmonary lobar resection can be treated using tube drainage alone, and small fistulas may be treated by transbronchial injection or with fibrin adhesives. [2][3][4][5] Surgery is required for large fistulas or cases with pyothorax, and open treatment and purging of pyothorax after plombage is performed in cases with poor infection control. 6) Open emergency treatment is safe, but places a heavy burden on the patient and medical staff.…”