Successful Treatment of &lt;i&gt;Cryptococcus laurentii&lt;/i&gt; Peritonitis in a Patient on Peritoneal Dialysis

Asano, Marina; Mizutani, Makoto; Nagahara, Yasuko; Inagaki, Koji; Kariya, Tetsuyoshi; Masamoto, Daijiro; Urai, Makoto; Kaneko, Yukihiro; Ohno, Hideaki; Miyazaki, Yoshitsugu; Mizuno, Masashi; Ito, Yasuhiko

doi:10.2169/internalmedicine.54.3586

Cited by 12 publications

(11 citation statements)

References 17 publications

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“…gattii have increased significantly since the 1970s, including in renal dialysis patients. The results of the current study also revealed that non- neoformans / gattii cryptococcal species account for a considerable proportion (approximately 27.8%, 5/18) of the cryptococcal species among renal dialysis patients [ 13 – 17 ], particularly C. laurentii or C. albidus . This observation is consistent with a recent global review of 44 previously published cases [ 11 ].…”

Section: Discussionsupporting

confidence: 60%

“…Of these articles, 735 were excluded because of duplication and/or an inappropriate content. Nearly all of these pooled cases of cryptococcosis during renal dialysis were single case reports [ 13 – 27 ]. Among these, 16 cases reported in 15 articles with definitive diagnosis of cryptococcosis were analyzed further.…”

Section: Resultsmentioning

confidence: 99%

“…neoformans / C . gattii species, which have higher MICs of current antifungal drugs, accounted for a large proportion of cryptococcal infections among renal dialysis patients [ 13 – 17 ]. Hence, cryptococcosis in renal dialysis patients should be further studied due to our poor understanding of this infection.…”

Section: Discussionmentioning

confidence: 99%

“…A considerable number of pooled cases (5/18) occurred in the past 5 years, which is likely to be related to the increasing number of renal dialysis patients worldwide [ 3 ]. Most of the current cases were collected from medical centers in major cities worldwide, including New York in the USA, Osaka in Japan, and Shanghai in China [ 13 , 14 , 22 ]. Thus, the availability of modern diagnostic tools might be relevant to the relatively high level of diagnosed cryptococcal infections in these cities.…”

Section: Discussionmentioning

confidence: 99%

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Cryptococcosis in HIV-negative Patients with Renal Dialysis: A Retrospective Analysis of Pooled Cases

et al. 2017

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Cryptococcosis is a lethal fungal infection mainly caused by Cryptococcus neoformans/C. gattii species. Currently, our understanding of cryptococcosis episodes in HIV-negative patients during renal dialysis remains scarce and fragmented. Here, we performed an analysis of pooled cases to systemically summarize the epidemiology and clinical characteristics of cryptococcosis among HIV-negative patients with renal dialysis. Using pooled data from our hospital and studies identified in four medical databases, 18 cases were identified and analyzed. The median duration time of renal dialysis for peritoneal renal dialysis and hemodialysis cases was 8 months and 36 months, respectively. Several non-neoformans/gattii species were identified among the renal dialysis recipients with cryptococcosis, particularly Cryptococcus laurentii and Cryptococcus albidus, which share similar clinical manifestations as those caused by C. neoformans and C. gattii. Our analyses suggest that physicians should consider the possibility of the occurrence of cryptococcosis among renal dialysis recipients even when cryptococcal antigen test result is negative. The timely removal of the catheter is crucial for peritoneal dialysis patients with cryptococcosis. In addition, there is a need for optimized antifungal treatment strategy in renal dialysis recipients with cryptococcal infections.

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Section: Discussionsupporting

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cryptococcosis in HIV-negative Patients with Renal Dialysis: A Retrospective Analysis of Pooled Cases

et al. 2017

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“…The clinical presentation of C. laurentii is similar to that of C. neoformans, but the cryptococcal antigen test is often negative (4), and the organism exhibits decreased fluconazole susceptibility (5,6). Therefore, accurate identification of the species is essential for treatment drug selection.…”

mentioning

confidence: 99%

Misidentification of a Rare Species, Cryptococcus laurentii, by Commonly Used Commercial Biochemical Methods and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Systems: Challenges for Clinical Mycology Laboratories

et al. 2016

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c Forty-two putative Cryptococcus laurentii isolates identified by the Vitek 2 system were collected in China. The gold standard, internal transcribed spacer (ITS) sequencing, confirmed that only two isolates were genuine C. laurentii. Bruker Biotyper matrix-assisted laser desorption ionization-time of flight mass spectrometry was able to identify the C. laurentii isolates with an expanded custom database. Cryptococcus laurentii is one of the very rare non-neoformans Cryptococcus species that cause human infections (1-3). The clinical presentation of C. laurentii is similar to that of C. neoformans, but the cryptococcal antigen test is often negative (4), and the organism exhibits decreased fluconazole susceptibility (5, 6). Therefore, accurate identification of the species is essential for treatment drug selection.China Hospital Invasive Fungal Surveillance Net (CHIF-NET) is a nationwide surveillance program for invasive fungal diseases (IFDs) in China (7). During a recent 5-year study period (2009 to 2014), 9,673 yeast isolates were collected, with 42 (0.4%) isolates initially identified as C. laurentii by Vitek 2 at participating hospitals. This unexpectedly high prevalence of C. laurentii than previously reported (e.g., ARTEMIS [1997 to 2007], 0.04%; SENTRY [2008 to 2012], 0%) (3, 8-10) prompted us to investigate further the identity of the isolates.The 42 putative C. laurentii isolates originated from 16 different hospitals, and the identity of the isolates was confirmed at the coordinating central laboratory by sequencing of the internal transcribed spacer (ITS) region, with results queried against the Centraalbureau voor Schimmelcultures (CBS) Fungal Biodiversity Center database (http://www.cbs.knaw.nl/Collections/Biolo MICSSequences.aspx) as previously described (7, 11). Furthermore, the isolates were reidentified by the Vitek 2 (bioMérieux, Marcy l'Etoile, France) yeast identification card and API 20C AUX method (bioMérieux) at the coordinating lab, with testing staff blinded to previous Vitek 2 and sequencing results.Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis was performed on all isolates by both the Vitek MS system (IVD Knowledgebase version 2.0; bioMérieux) and the Bruker Autoflex Speed TOF/TOF MS system (Biotyper version 3.1 software; Bruker Daltonics, Billerica, MA, USA), according to the manufacturer's instructions. Mass spectral profiles of the two C. laurentii clinical isolates confirmed by ITS sequencing were used to construct a main spectrum profile (MSP) dendrogram along with reference spectra of C. laurentii and other Cryptococcus species provided in the Bruker database, for fingerprint relatedness analysis. These data were subsequently used to expand the Bruker MALDI-TOF MS database following the manufacturer's instructions (12).Among 42 putative C. laurentii isolates identified by the Vitek 2 system at local hospitals, only two isolates (4.8%) were confirmed as C. laurentii by sequencing of the ITS region. Of the remaining 40 isolat...

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Catheter-related infection due to Papiliotrema laurentii in an oncologic patient: Case report and systematic review

Londero¹,

Zanrosso²,

Corso

et al. 2019

The Brazilian Journal of Infectious Diseases

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Successful Treatment of <i>Cryptococcus laurentii</i> Peritonitis in a Patient on Peritoneal Dialysis

Cited by 12 publications

References 17 publications

Cryptococcosis in HIV-negative Patients with Renal Dialysis: A Retrospective Analysis of Pooled Cases

Cryptococcosis in HIV-negative Patients with Renal Dialysis: A Retrospective Analysis of Pooled Cases

Misidentification of a Rare Species, Cryptococcus laurentii, by Commonly Used Commercial Biochemical Methods and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Systems: Challenges for Clinical Mycology Laboratories

Catheter-related infection due to Papiliotrema laurentii in an oncologic patient: Case report and systematic review

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