Successful treatment of infected wound dehiscence after minimally invasive locking-plate osteosynthesis of tibial pilon and calcaneal fractures by plate preservation, surgical debridement and antibiotics

Ieropoli, Giandavide; Villafañe, Jorge Hugo; Zompi, Silvia Chiara; Morozzo, Umberto; D’Ambrosi, Riccardo; Usuelli, Federico Giuseppe; Berjano, Pedro

doi:10.1016/j.foot.2017.10.001

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Moreover, surgery is associated with an increased risk of stiffness and limitations in ankle mobility, higher costs, and additional complications associated with surgery itself, including infection and deep vein thrombosis. It should be noted that ankle and foot surgery showed growing interest over the last decade ( 45 , 46 ).…”

Section: Discussionmentioning

confidence: 99%

Acute Ankle Sprain Management: An Umbrella Review of Systematic Reviews

et al. 2022

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Even though ankle sprains are among the most frequent musculoskeletal injuries seen in emergency departments, management of these injuries continues to lack standardization. Our objective was to carry out an umbrella review of systematic reviews to collect the most effective evidence-based treatments and to point out the state-of-the-art management for this injury. PubMed, Scopus, Web of Science, and the Cochrane library were searched from January 2000 to September 2020. After removing duplicates and applying the eligibility criteria, based on titles and abstracts, 32 studies were screened. At the end of the process, 24 articles were included in this umbrella review with a mean score of 7.7/11 on the AMSTAR quality assessment tool. We found evidence supporting the effectiveness of non-surgical treatment in managing acute ankle sprain; moreover, functional treatment seems to be preferable to immobilization. We also found evidence supporting the use of paracetamol or opioids as effective alternatives to non-steroidal anti-inflammatory drugs to reduce pain. Furthermore, we found evidence supporting the effectiveness of manipulative and supervised exercise therapy to prevent re-injury and restore ankle dorsiflexion.

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Section: Discussionmentioning

confidence: 99%

Acute Ankle Sprain Management: An Umbrella Review of Systematic Reviews

et al. 2022

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“…In biofilm formation, microbiota colonization is considered to be the critical first step for initiating the attachment and colonization of biotic surfaces by planktonic cells [10]. The microbes in the biofilm state are 1,000 times more resistant to antimicrobial agents compared to those in the planktonic state [13, 15]. Therefore, eradiation or degradation of biofilms is an essential approach for the control of biofilm-forming bacterial infections.…”

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confidence: 99%

A new transformation method with nanographene oxides of antisense carrying <i>yycG</i> RNA improved antibacterial properties on methicillin-resistant <i>Staphylococcus aureus</i> biofilm

Liu

Zhang

et al. 2019

J. Vet. Med. Sci.

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Staphylococcus aureus has the potential to opportunistically cause infectious diseases. The aim of this study was to determine the antimicrobial effects of novel graphene oxide (GO)-polyethylenimine (PEI)-based antisense yycG (ASyycG) on the inhibition of methicillin-resistant S. aureus (MRSA) biofilm formation. In current study, a novel GO-PEI-based recombinant ASyycG vector transformation strategy was developed to produce ASyycG. The mechanical features including zeta-potential and particle size distributions were evaluated by: GO; GO-PEI and GO-PEI-ASyycG. The recombinant ASyycG vector was transformed into MRSA cells, and the expression levels of the yycF/G and icaADB genes were determined and compared by quantitative real-time PCR (qPCR) assays. The recombinant ASyycG plasmids were subsequently modified with a gene encoding enhanced green fluorescent protein (ASyycG-eGFP) as a reporter gene, and the transformation efficiency was assessed by the fluorescence intensity. The biofilm biomass and bacterial viability of the MRSA strains were evaluated by crystal violet assay, colony-forming unit assays and confocal laser scanning microscopy. The results showed that the Z-average sizes of GO-PEI-ASyycG were much larger than those of GO or GO-PEI. The GO-PEI-based strategy significantly increased the efficiency of ASyycG transformation. The GO-PEI-ASyycG-transformed MRSA strain had the lowest expression levels of the biofilm formation-associated genes. Furthermore, GO-PEI-ASyycG suppressed biofilm aggregation and improved bactericidal effects on the MRSA after 24 hr of biofilm establishment. Our findings demonstrated that GO-PEI based antisense yycG RNA will be an effective method for management of MRSA infections.

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Care and Management of Surgical Wounds, Wounds Dehiscence, and Scars

Parada

Mangelsdorff

2022

Foot and Ankle Disorders

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Successful treatment of infected wound dehiscence after minimally invasive locking-plate osteosynthesis of tibial pilon and calcaneal fractures by plate preservation, surgical debridement and antibiotics

Cited by 5 publications

References 28 publications

Acute Ankle Sprain Management: An Umbrella Review of Systematic Reviews

Acute Ankle Sprain Management: An Umbrella Review of Systematic Reviews

A new transformation method with nanographene oxides of antisense carrying <i>yycG</i> RNA improved antibacterial properties on methicillin-resistant <i>Staphylococcus aureus</i> biofilm

Care and Management of Surgical Wounds, Wounds Dehiscence, and Scars

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