Successful Treatment of Focal Segmental Glomerulosclerosis in Association with Mantle Cell Lymphoma

Mantle cell lymphoma (MCL) is a rare lymphoid neoplasm occurring in about 6% of all non-Hodgkin's lymphomas. Although nephrotic syndrome due to various glomerulopathies is well described in patients with lymphomas, focal segmental glomerulosclerosis (FSGS) with MCL has been reported only once before. We present a second case of FSGS associated with MCL that was resistant to standard treatment of FSGS but resolved when the underlying MCL was treated.

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“…Only one other case of FSGS in association with MCL has been described 1. Lymphocytosis was the key to diagnosis in both cases (including ours).…”

Section: Discussionsupporting

confidence: 51%

Focal segmental glomerulosclerosis in a patient with mantle cell lymphoma

et al. 2015

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“…12 cases of p-GN in the setting of MCL have been described. [ 3 4 5 6 7 8 9 10 11 12 ] LIN due to MCL has been observed in 4 cases. [ 13 14 15 16 ] The coexistence of LIN and p-GN due to MCL is extremely rare.…”

Section: Discussionmentioning

confidence: 99%

Lymphomatous interstitial nephritis coexistent with paraneoplastic crescentic membranoproliferative glomerulonephritis in a case of mantle cell lymphoma

Etta¹,

Rao

Reddy

et al. 2020

Indian J Nephrol

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Mantle cell lymphoma (MCL) is a rare aggressive lymphoproliferative disorders (LPD) of B-cell lymphoma, which usually presents in advanced stages at initial diagnosis. Renal involvement in MCL is very rare, especially the combined presence of both glomerular and interstitial disease. We report on a patient with lymphomatous interstitial nephritis (LIN) coexistent with paraneoplastic crescentic membranoproliferative glomerulonephritis (MPGN), subsequently diagnosed to have disseminated MCL with bone marrow and lymph nodal infiltration. He was treated with rituximab-based chemotherapy and went into complete renal remission at 6-months of follow up.

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“…13 out of 17 cases biopsyproven cases described so far represent various patterns of glomerulonephritis. In its turn, 4 out of these 13 cases were diagnosed as MPGN by pathology [1,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], and none of them was diagnosed as MN.…”

Section: Discussionmentioning

confidence: 99%

Mantle Cell Lymphoma associated with Membranoproliferative and Membranous Glomerulonephritis: Report of Two Cases

Захарова¹

2016

CSROA

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pathology patterns, reported in the literature, are represented by interstitial or glomerular specific infiltration and paraneoplastic glomerulonephritis (GN)-mainly Membranous Nephropathy (MN) and Membranoproliferative Glomerulonephritis (MPGN), and rarely Minimal Change Disease (MCD), Focal Segmental Glomerulosclerosis (FSGS) and Crescentic Glomerulonephritis (CGN) [1-10]. Mantle Cell Lymphoma (MCL) is an aggressive lymphoid neoplasm, representing 5-10% of all B-cell NHL and characterized by the proliferation of mature B-lymphocytes, that infiltrate lymphoid tissues, bone marrow, peripheral blood, and extranodal sites. The hallmark of this lymphoma is translocation t(11;14) (q13; q32), which results in overexpression of Cyclin D1 [11]. Kidney involvement in MCL, reported rarely in living patients, is caused either by direct lymphoid infiltration or by multiple mechanisms (cytokines, immune complexes etc.) triggering paraneoplastic GN. Data retrieval allowed us to find 17 biopsyproven cases, have been described in the literature so far: 3 cases of renal MCL infiltration, 1 case of interstitial nephritis without lymphoid infiltration, 5 cases of proliferative GN, 1 case of MCD, 1 case of FSGS, 1 case of MPGN, 1 case of CGN, and 4 cases with the combination of MCL infiltration and GN (3 with MPGN and 1 with CGN) [12-26]. We didn't find any data, reporting membranous nephropathy in MCL. Here we present two cases of MCL with GN, diagnosed on the basis of renal biopsy findings, one case of MPGN and another with MN, and discuss the diagnostics difficulties and treatment results.

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Successful Treatment of Focal Segmental Glomerulosclerosis in Association with Mantle Cell Lymphoma

Cited by 9 publications

References 14 publications

Focal segmental glomerulosclerosis in a patient with mantle cell lymphoma

Focal segmental glomerulosclerosis in a patient with mantle cell lymphoma

Lymphomatous interstitial nephritis coexistent with paraneoplastic crescentic membranoproliferative glomerulonephritis in a case of mantle cell lymphoma

Mantle Cell Lymphoma associated with Membranoproliferative and Membranous Glomerulonephritis: Report of Two Cases

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