Successful Treatment of Facial Acne Fulminans: Antimicrobial Agents and Oral Prednisolone as Promising Regimes

Siadat, Amir Hossein; Bostakian, Anis; Abtahi‐Naeini, Bahareh; Shahbazi, Masoom

doi:10.1155/2017/7092910

Cited by 5 publications

(8 citation statements)

References 14 publications

(20 reference statements)

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“…AF is a rare condition that is considered to be the most severe form of acne. The primary features of this disease include sudden onset, severe and often ulcerating acne, fever, polyarthritis, leukocytosis, and plaquetosis 2 . The patient in this report showed a typical manifestation of AF.…”

Section: Discussionmentioning

confidence: 99%

“…The SAPHO syndrome is an association of distinct skin disorders with pustules with osteoarticular inflammation 10 ; however, the patient in our study had no bony involvement nor impact on internal organs. The treatment of AFs is still a challenge as there have been many reports of different treatments 2,9,11 . Our patient was treated with a combined use of antibiotics for a long period, although his clinical signs did not improve (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

“…It is characterized by the sudden onset of painful and ulcerative pustules. The systemic symptoms include high fever and polyarthralgia 1,2 . AF mainly affects young male adolescents with a history of acne vulgaris 3,4 .…”

Section: Introductionmentioning

confidence: 99%

“…to 4 months, and subsequently, should be gradually reduced to prevent relapse when the dosage is decreased1,2,6 . We did not give isotretinoin to the patient because this drug could trigger AF in some cases5,6 .…”

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confidence: 99%

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Acne fulminans in a Vietnamese boy successfully treated with prednisolone and ibuprofen: A case report

2018

Biomed. Res. Ther.

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Background: Acne fulminans (AF) is a rare disorder, the most severe form of the entire clinical spectrum of acne. It is characterized by the emergence of painful inflammatory nodules that turn into ulcers, concomitant with systemic manifestations. Here, we report for the first time a Vietnamese boy with Acne fulminans successfully treated with prednisolone and ibuprofen. Case presentation: The patient is a 14-year-old male teenager with moderate acne since the age of 13. After a day of swimming, his acne suddenly became inflamed and painful lesions were present on his face and back. He had high fever and polyarthritis, and tests showed leukocytosis, neutrophilia, and elevated C-reactive protein (CRP). Severe infection was diagnosed and treated by addition of antibacterial therapy for a long period, however, the condition did not improve. When called upon to evaluate the patient, we established the diagnosis of acne fulminans and initiated treatment with prednisone (1mg/kg/day) and ibuprofen (500 mg for two times daily). Following this treatment regimen, there was a rapid improvement. Conclusion: Herein, we have reported a Vietnamese boy with typical AF, but delayed diagnosis and treatment because of a rare condition. Our results support the role and benefit of prednisolone for AF treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Acne fulminans in a Vietnamese boy successfully treated with prednisolone and ibuprofen: A case report

2018

Biomed. Res. Ther.

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“…Многочисленные исследования для определения оптимальной терапевтической тактики ведения пациентов с фульминантными акне, в том числе стероидными акне (акне «бодибилдеров»), рекомендуют сочетанное применение стероидов и системного изотретиноина (СИ) [23,24].…”

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Fulminant acne. Modern solution of the problem

Drozhdina

2019

Vestnik dermatologii i venerologii

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Фульминантные акне. Современное решение проблемы Дрождина М. Б. Кировский государственный медицинский университет Министерства здравоохранения Российской Федерации 610998, Российская Федерация, г. Киров, у л. Карла Маркса, д. 112 Описаны современные представления об этиологических факторах, лежащих в основе редкого, тяжелого заболевания -фульминантных акне, влиянии генетических и экспосом-факторов на формирование заболевания, особенностях патогенеза данной формы акне. Выделены основные патогенетические факторы, влияющие на дебют и течение фульминантных акне: Cutibacterium и микробиом кожных покровов в целом; гиперпродукция кожного сала себоцитами при непосредственном участии дигидротестостерона, прогестерона, инсулиноподобного фактора роста-1; особенности врожденного иммунитета, фолликулярный гиперкератоз. Описаны клиника, осложнения и оптимальная терапевтическая тактика на современном этапе. Представлен клинический случай с успешным терапевтическим исходом. Ключевые слова: фульминантные акне, Cutibacterium, экспосом, микробиом, дигидротестостерон, прогестерон, инсулиноподобный фактор роста-1, изотретиноин Lidose Конфликт интересов: автор заявляет об отсутствии потенциального конфликта интересов, требующего раскрытия в данной статье. Для цитирования: Дрождина М. Б. Фульминантные акне. Современное решение проблемы. Вестник дерматологии и венерологии. 2019;95(4):79-86. https://doi.Modern ideas about the etiological factors underlying a rare, serious illness -fulminant acne, the influence of genetic and exposure factors on the formation of the disease, and the pathogenesis of this form of acne are described. The main pathogenetic factors affecting the debut and course of fulminant acne were identified: Cutibacterium and the microbiome of the skin as a whole; sebum overproduction of sebum with the direct participation of dihydrotestosterone, progesterone, insulin-like growth factor-1; features of innate immunity, follicular hyperkeratosis. The clinic, complications and optimal therapeutic tactics at the present stage are described. A clinical case with a successful therapeutic outcome is presented.

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A Case of Acne Fulminans

McKegney¹,

Schneider²

2022

Journal of Pediatric Health Care

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Successful Treatment of Facial Acne Fulminans: Antimicrobial Agents and Oral Prednisolone as Promising Regimes

Cited by 5 publications

References 14 publications

Acne fulminans in a Vietnamese boy successfully treated with prednisolone and ibuprofen: A case report

Acne fulminans in a Vietnamese boy successfully treated with prednisolone and ibuprofen: A case report

Fulminant acne. Modern solution of the problem

A Case of Acne Fulminans

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