Successful Treatment of Disseminated Relapsed Medulloblastoma in an Infant by Primary Radiotherapy

Narendran, Aru; Monteleone, Philip; Steele, David A.; Hicks, Richard J.; Kelleher, John F.

doi:10.1097/00043426-200101000-00012

Cited by 1 publication

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“…Medical literature reports few cases of abdominal metastasis throughout ventricular shunts 18,19 , but hematogenic pathway is the main dissemination mechanism, as proposed in 1973; 58 cases of peritoneal metastasis through ventricular shunt were found by Liacono et al in a review of literature published in 2006, considering every type of CNS tumor metastasis. 18 Systemic metastases are associated with disease progression and higher grade of anaplasia 9,11,13,21 . Although controversial in adult medulloblastoma the prognostic value of anaplasia grade, in children population it is well established 9,11 .…”

Section: Case Reportmentioning

confidence: 99%

Thoracic medulloblastoma metastasis

Polverini¹,

Bortoluzzi²,

Filho³

et al. 2018

jbnc

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Introduction: Medulloblastoma is one of the most frequent malignancies of Central Nervous System (CNS) in childhood and has low incidence in adult population. Recurrences are frequent in both populations; systemic metastasis is a rare event. Objective: Report an unusual medulloblastoma case evolution, with thorax metastasis after 6 years of quiescence and compare results with literature data. Methods: Registers survey of previously operated patient from a posterior fossa medulloblastoma with diagnose of thoracic metastasis. Acquired data were analyzed and compared with those from literature. Case report: Twenty-two years-old patient, with a previously operated on posterior fossa medulloblastoma . Six years later, presents with asthenia and vertigo: an x-ray diagnosis of a lesion in the apex of left chest is confirmed with a thoracic computerized tomography. A laparoscopic biopsy is done, disclosing an infiltrative tumor, adherent to the parietal pleura and highly vascularized. AP diagnosis was compatible with metastasis of medulloblastoma. Conclusion: Posterior fossa recurrences are frequent in the adult population, followed by the subfrontal region. About 5% of meduloblastoma metastases are systemic, especially in bones (77%), and even rarer in the lungs, as shown in this report.

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