Successful Treatment of Coexistence of Diffused Large B Cell Lymphoma and Lung Adenocarcinoma, a Case Report

Du, Chi; Gao, Fei; Wen, En; Liu, Xiulan; Du, Lihui; Luo, Feng

doi:10.1016/j.ijge.2016.07.001

Cited by 5 publications

(11 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors speculate that collision tumors that include gastrointestinal tract tumors and lymphomas are more common because of the higher exposure to external substances. The coexistence of pulmonary adenocarcinoma and malignant lymphoma in the same location is an extremely rare event [1,2]. Some reports have been published of collision cancers consisting of different histological types of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma

Sato¹,

Sakon²,

Tanaka³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background The collision tumor consisted of two malignant tumors that independently developed and were contiguous or had invaded each other. Among the reports of malignant collision tumors, collision tumors consisting of lung cancer and malignant lymphoma are extremely rare. We report case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma.Case presentationA 74-year-old man was admitted to the hospital due to identification of an abnormal nodular shadow in the right upper lobe on chest computed tomography following a chest X-ray. At the time of admission, a swollen lymph node of 7 cm × 5 cm was palpated in the left neck, and serum examination showed an abnormally high level of soluble interleukin-2 receptor. Close examination led to a diagnosis of stage IA squamous cell carcinoma of the lung and stage IVA malignant lymphoma, and treatment for the malignant lymphoma was prioritized. However, due to progression of lung cancer, a right upper lobectomy with lymph node dissection was performed. Pathological findings showed that squamous cell carcinoma and malignant lymphoma were both present in the same lesion.ConclusionOnly two cases of collision tumors consisting of malignant lymphoma and primary lung cancer were reported [1] [2] and this case is considered to be the third rare case in the world. As the rate of complications with other malignancies in patients with diffuse large B-cell lymphoma is high, in the case of advanced stage malignant lymphoma, physicians must consider which treatment should be prioritized according to the degree of progression of coexisting solid tumors.

show abstract

Section: Discussionmentioning

confidence: 99%

Case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma

Sato¹,

Sakon²,

Tanaka³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…All were alive in the follow-up. To be specific, Du et al [ 5 ] reported that lung adenocarcinoma and lymphoma were well controlled in certain cases after 4 cycles of chemotherapy with gemcitabine, cisplatin (GP) regimen, as well as 2 cycles of chemotherapy using cyclophosphamide, adriamycin, vincristine, prednisone (CHOP) regimen. No recurrence was observed within 3 years.…”

Section: Discussionmentioning

confidence: 99%

Synchronous primary pulmonary adenocarcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

Sun

Zhang

Ke³

et al. 2020

Medicine

View full text Add to dashboard Cite

Rationale: Synchronous pulmonary lymphoma and carcinoma is relatively rare. And synchronous pulmonary lymphoma and adenocarcinoma in the same site is extremely rare. Patient concerns: We presented a 69-year-old female with a tumor mass in right upper lung. Diagnosis: Pathological and immunohistochemical findings revealed lung adenocarcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. Interventions: The patient received thoracoscopic guided right upper lobectomy and focal lymph node dissection after systemic anesthesia. Besides, 6 cycles of chemotherapy were given based on meprednisone, gemcitabine and cisplatin in local hospital. Outcomes: In the 12-month follow-up, the patient was still alive with no local recurrence, metastasis and lymph node involvement. Lesson: A comprehensive literature research was performed, and 6 cases of synchronous pulmonary lymphoma and adenocarcinoma in the same site and 10 cases in different sites were identified since 2000. Most patients with synchronous pulmonary lymphoma and carcinoma were middle-aged and elderly with the median age was 64 years presenting a male predisposition. The most frequent type of primary pulmonary lymphoma was B-cell non Hodgkin lymphoma, especially mucosa-associated lymphoid tissue lymphoma, and the lung cancer is predominantly adenocarcinoma.

show abstract

“…Three coexistent cancers may originate from the same source [14] or generate independently. [8] Although the colon adenocarcinoma and DLBCL were diagnosed in the same time, the relationship between these 2 malignancies regarding to their origin is not clear. When MDS was diagnosed, no chemotherapy had been applied, indicating that the origin of MDS in the present case was not secondary to chemotherapeutic treatment.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of colon adenocarcinoma, diffuse large B-cell lymphoma, and myelodysplastic syndrome

Wang

2019

Medicine

View full text Add to dashboard Cite

Rationale:Cases of coexistence of 2 cancers, such as colorectal cancer and diffuse large B-cell lymphoma (DLBCL), colorectal cancer and myelodysplastic syndrome (MDS), and DLBCL with MDS, have been reported, whereas the coexistence of 3 different cancers in a patient is extremely rare. Here we report a case of co-occurrence of colon adenocarcinoma, DLBCL, and MDS in a 78-year-old Chinese man.Patient concerns:He presented to our hospital with palpable lumps in the abdomen without any of the following symptoms including abdominal pain, fever, contact pain, tenesmus, changes in bowel habits and shape, nausea, and vomiting.Diagnoses:The patient was first diagnosed with sigmoid colon adenocarcinoma and DLBCL in the right ascending colon using enhanced computed tomography, colonoscopy, and immunohistochemistry. After resection of the sigmoid adenocarcinoma and DLBCL, MDS was diagnosed according to the results of routine blood tests, bone marrow aspiration smear, and flow cytometry.Interventions:Overall, the patient was treated with surgical resection of the sigmoid adenocarcinoma and DLBCL of the colon, combined with 4 cycles of chemotherapies targeting MDS.Outcomes:Blood test results and follow-up indicated that the treatment regimen showed promising outcomes.Lessons:In conclusion, a case of synchronous existence of colon cancer, DLBCL, and MDS is reported, which suggests that careful attention should be paid clinically to checking the state of bone marrow for elderly cancer patients. Efforts are also needed to establish an effective system for distinguishing the origin of multi-existent cancers and to develop effective therapeutic regimens for multi-existent cancers with fewer side effects.

show abstract

Successful Treatment of Coexistence of Diffused Large B Cell Lymphoma and Lung Adenocarcinoma, a Case Report

Cited by 5 publications

References 7 publications

Case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma

Case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma

Synchronous primary pulmonary adenocarcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

Coexistence of colon adenocarcinoma, diffuse large B-cell lymphoma, and myelodysplastic syndrome

Contact Info

Product

Resources

About