2016
DOI: 10.1111/jdv.13758
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Successful treatment of bullous pemphigoid with omalizumab as corticosteroid‐sparing agent: report of two cases and review of literature

Abstract: Until recently IgG autoantibodies against the basal membrane proteins BP180 und BP230 were considered to be causative in the pathogenesis of BP. However, new in vitro studies as well as data from experimental mouse models have indicated that in addition to specific IgG, also IgE antibodies against BP180 and BP230 play a role in the development of this disease. Based on these new findings, new treatment modalities of BP became possible.

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Cited by 59 publications
(36 citation statements)
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References 30 publications
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“…Yayınlanmış verilere göre, küçük olgu serileri ve birkaç olgu raporunda OMZ yan etkisi olmayan ve başarılı bir ajan olarak bulunmuştur 18,19,21,26,27 . Buna ek olarak, önceki bildirilerde OMZ'nin steroid koruyucu etkilerini destekleyen sonuçlar vardır 27 . Oxford Kanıta Dayalı Tıp Merkezi'nin önerilerin kanıt derecelerine göre seviyelendirilmesinde BP için OMZ tartışmalı kanıt düzeyinde değerlendirilmiştir.…”
Section: Sonuçunclassified
“…Yayınlanmış verilere göre, küçük olgu serileri ve birkaç olgu raporunda OMZ yan etkisi olmayan ve başarılı bir ajan olarak bulunmuştur 18,19,21,26,27 . Buna ek olarak, önceki bildirilerde OMZ'nin steroid koruyucu etkilerini destekleyen sonuçlar vardır 27 . Oxford Kanıta Dayalı Tıp Merkezi'nin önerilerin kanıt derecelerine göre seviyelendirilmesinde BP için OMZ tartışmalı kanıt düzeyinde değerlendirilmiştir.…”
Section: Sonuçunclassified
“…High-affinity IgE receptor (FcεRI)-bound IgE on mast cells and eosinophils may be involved in the degranulation of such cells following their capture of shed extracellular fragments of COL17, in turn resulting in the development of urticarial erythema in BP 76 . Reports of BP cases successfully treated with anti-IgE monoclonal antibodies also support the potential of IgE as a therapeutic target in BP 77, 78 .…”
Section: Pemphigoidmentioning
confidence: 82%
“…To date, 15 cases of BP treated with omalizumab have been reported, with one of them at infant disease (Balakirski, Alkhateeb, Merk, Leverkus, & Megahed, 2016;Dufour et al, 2012;Gönül, Keseroglu, Ergin, Özcan, & Erdem, 2016;Menzinger, Kaya, Schmidt, Fontao, & Laffitte, 2018;Yalcin, Genc, Celik, & Gumuslu, 2014;Yu, Crew, Messingham, Fairley, & Woodley, 2014). Elevated IgE levels and/or eosinophilia are the leading facts to recommend this monoclonal antibody in BP (Yu et al, 2014).…”
Section: Discussionmentioning
confidence: 99%