Successful Treatment of Brugia pahangi in Naturally Infected Cats with Ivermectin

Taweethavonsawat, Piyanan; Chungpivat, Sudchit

doi:10.3347/kjp.2013.51.6.759

Cited by 4 publications

(2 citation statements)

References 10 publications

(15 reference statements)

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“…The lesion resulting from zoonotic filariasis is mostly a solitary nodule; thus, surgical removal of the lesion may be adequate [ 19 ]. Drug treatments such as ivermectin and selamectin have been shown to effectively eliminate the worm in cats and dogs [ 20 , 21 ]. However, the necessity of giving those medications to people with zoonotic filariasis is still questionable.…”

Section: Discussionmentioning

confidence: 99%

Filariasis of the breast caused by Brugia pahangi: A concomitant finding with invasive ductal carcinoma

Thongpiya

Sa-nguanraksa

Samarnthai

et al. 2021

Parasitology International

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Extralymphatic filariasis is an uncommon phenomenon that can be caused by several lymphatic filarial species, including zoonotic filaria of animal origins. In this study, we report a case of a 64-year-old Thai woman who presented with a lump in her left breast that was diagnosed with invasive ductal carcinoma. At the same time, a small nodule was found in her right breast, via imaging study, without any abnormal symptoms. A core needle biopsy of the right breast nodule revealed a filarial-like nematode compatible with the adult stage of Brugia sp. A molecular identification of the nematode partial mt 12rRNA gene and ITS1 suggested the causative species as closely related to Brugia pahangi , a zoonotic lymphatic filaria of animals such as cats and dogs. The sequence of the partial mt 12rRNA and ITS1 gene in this patient was 94% and 99% identical to the previously reported sequence of mt 12rRNA and ITS1 genes of B. pahangi. The sequence of ITS1 gene is 99% similar to B. pahangi microfilaria from infected dogs in Bangkok, which was highly suspected of having a zoonotic origin. As far as we know, this is the first case report of B. pahangi filariasis presented with a breast mass concomitantly found in a patient with invasive ductal carcinoma. This raised serious concern regarding the zoonotic transmission of filariasis from natural animal reservoirs.

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Section: Discussionmentioning

confidence: 99%

Filariasis of the breast caused by Brugia pahangi: A concomitant finding with invasive ductal carcinoma

Thongpiya

Sa-nguanraksa

Samarnthai

et al. 2021

Parasitology International

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“…Ivermectin is an effective microfilaricidal drug, especially filariasis. Also, ivermectin treatment in cats naturally infected with B. pahangi results in amicrofilaremia within 9 weeks (Taweethavonsawat & Chungpivat, 2013).…”

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confidence: 99%

Efficacy of tetracycline and enrofloxacin against wolbachia spp. in microfilaria of Brugia Pahangi

Piromkij

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Brugia pahangi is a major causative agent of animal lymphatic filariasis, one of the neclected tropical disease. Recent studies have also indicated that B. pahangi can cause clinical infection in human, with clinical appearances which are consistent with human lymphatic filariasis. Nowadays, the recognition of Wolbachia as new alternative drug choice for treatment and control of lymphatic filariasis is the most important in anti-filarial chemotherapy. Since, Wolbachia play important roles, including the development, viability, fertility and fecundity of filarial parasites. Depletion of Wolbachia results in sterilization, stunting and death of filarial worms. In this study, we investigated the effects of tetracycline and enrofloxacin on B. pahangi microfilarial motility and on Wolbachia depletion. Results showed that motility score of microfilaria treated with tetracycline were markedly reduced and high concentrations of enrofloxacin also can reduced worm motility. Quantitative real-time PCR indicated that the change of Wolbachia population in each treatment groups were decreased gradually. MEC of tetracycline was 128 and 32 ?g/ml at 24 and 48 hours, respectively, while MEC of enrofloxacin was 512 ?g/ml at 24 hours. Thus, tetracyclines should be considered as a drug of choice for treatment of animal lymphatic filariasis and suggest new antibiotic, enrofloxacin, as a substitute.

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Comparison of efficacy of ivermectin and diethylcarbamazine against naturally infected Brugia malayi microfilaria in dogs

et al. 2019

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Successful Treatment of Brugia pahangi in Naturally Infected Cats with Ivermectin

Cited by 4 publications

References 10 publications

Filariasis of the breast caused by Brugia pahangi: A concomitant finding with invasive ductal carcinoma

Filariasis of the breast caused by Brugia pahangi: A concomitant finding with invasive ductal carcinoma

Efficacy of tetracycline and enrofloxacin against wolbachia spp. in microfilaria of Brugia Pahangi

Comparison of efficacy of ivermectin and diethylcarbamazine against naturally infected Brugia malayi microfilaria in dogs

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