Successful treatment of bilateral endogenous <i>Fusarium solani</i> endophthalmitis in a patient with acute lymphocytic leukaemia

Rizzello, Ilaria; Castagnetti, Fausto; Toschi, P. G.; Bertaccini, Patrizia; Paolucci, Marina; Faccioli, Luca; Spinardi, Luca; Lewis, Russell E.; Cavo, Michèle; Stanzani, Marta

doi:10.1111/myc.12697

Cited by 16 publications

(10 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are several reports of immunosuppressed patients developing severe fungal infections despite antifungal prophylaxis . Fluconazole and echinocandins are common well‐tolerated choices for antifungal prophylaxis in patients with ALL; echinocandins, as opposed to fluconazole, have some activity against Aspergillus .…”

Section: Discussionmentioning

confidence: 99%

“…There are several reports of immunosuppressed patients developing severe fungal infections despite antifungal prophylaxis. [15][16][17][18][19] Fluconazole and echinocandins are common well-tolerated choices for antifungal prophylaxis in patients with ALL 19 ; echinocandins, as opposed to fluconazole, have some activity against Aspergillus. Despite antifungal prophylaxis and the anti-Aspergillus activity of echinocandins, breakthrough invasive fungal infections can still occur, and most echinocandin-associated breakthrough mold infections are still due to aspergillosis, not IF.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Invasive fusariosis masquerading as extramedullary disease in rapidly progressive acute lymphoblastic leukemia

Ligon

Natarajan

Shalabi

et al. 2019

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Invasive fusariosis (IF) most commonly occurs in patients with hematologic malignancies and severe neutropenia, particularly during concomitant corticosteroid use. Breakthrough infections can occur in high‐risk patients despite Aspergillus‐active antifungal prophylaxis. We describe a patient with rapid acute lymphoblastic leukemia (ALL) progression who presented with multifocal skin nodules thought to be choloromatous disease. These lesions were ultimately diagnosed as IF and the patient had two simultaneously active disease processes. This case highlights the importance of pathologic diagnosis of new skin lesions in ALL patients, even during leukemia progression, and demonstrates that IF can occur despite normal neutrophil counts and Aspergillus‐active prophylaxis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Invasive fusariosis masquerading as extramedullary disease in rapidly progressive acute lymphoblastic leukemia

Ligon

Natarajan

Shalabi

et al. 2019

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…Endophthalmitis is occasionally seen with disseminated fusariosis and may be associated with loss of vision 55 . Case series have reported various combinations of systemic antifungal agents, intravitreal antifungal agents and vitrectomy 179–185 . Given that voriconazole has good penetration into the eye, we moderately recommend systemic and intravitreal administration over amphotericin B ( Moderate recommendation, Level III evidence ).…”

Section: Question 4 What Are the Recommended Antifungal Treatments For The Most Common Nami Including Current First‐line And Salvage Treamentioning

confidence: 99%

“…55 Case series have reported various combinations of systemic antifungal agents, intravitreal antifungal agents and vitrectomy. [179][180][181][182][183][184][185] Given that voriconazole has good penetration into the eye, we moderately recommend systemic and intravitreal administration over amphotericin B (Moderate recommendation, Level III evidence). Involvement of an experienced ophthalmologist is strongly recommended (Strong recommendation, Level III evidence).…”

Section: Treatment Of Endophthalmitis Due To Fusarium Speciesmentioning

confidence: 99%

See 1 more Smart Citation

Consensus guidelines for the diagnosis and management of invasive fungal disease due to moulds other than Aspergillus in the haematology/oncology setting, 2021

Bupha‐Intr

Butters

Reynolds

et al. 2021

Internal Medicine Journal

View full text Add to dashboard Cite

Invasive fungal disease (IFD) due to moulds other than Aspergillus is a significant cause of mortality in patients with malignancies or post haemopoietic stem cell transplantation. The current guidelines focus on the diagnosis and management of the common non‐Aspergillus moulds (NAM), such as Mucorales, Scedosporium species (spp.), Lomentospora prolificans and Fusarium spp. Rare but emerging NAM including Paecilomyces variotii, Purpureocillium lilacinum and Scopulariopsis spp. are also reviewed. Culture and histological examination of tissue biopsy specimens remain the mainstay of diagnosis, but molecular methods are increasingly being used. As NAM frequently disseminate, blood cultures and skin examination with biopsy of any suspicious lesions are critically important. Treatment requires a multidisciplinary approach with surgical debridement as a central component. Other management strategies include control of the underlying disease/predisposing factors, augmentation of the host response and the reduction of immunosuppression. Carefully selected antifungal therapy, guided by susceptibility testing, is critical to cure. We also outline novel antifungal agents still in clinical trial which offer substantial potential for improved outcomes in the future. Paediatric recommendations follow those of adults. Ongoing epidemiological research, improvement in diagnostics and the development of new antifungal agents will continue to improve the poor outcomes that have been traditionally associated with IFD due to NAM.

show abstract

Invasive coinfection by rare fungi during the prehematopoietic stem cell transplant period in a child with acute lymphoblastic leukemia

Hernández,

Pérez,

Ramírez

et al. 2024

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Successful treatment of bilateral endogenous Fusarium solani endophthalmitis in a patient with acute lymphocytic leukaemia

Abstract: SummaryFusarium spp. are an uncommon cause of fungaemia in immunocompromised and neutropenic patients that may hematogenously disseminate to the eyes. Herein, we

Cited by 16 publications

References 38 publications

Invasive fusariosis masquerading as extramedullary disease in rapidly progressive acute lymphoblastic leukemia

Invasive fusariosis masquerading as extramedullary disease in rapidly progressive acute lymphoblastic leukemia

Consensus guidelines for the diagnosis and management of invasive fungal disease due to moulds other than Aspergillus in the haematology/oncology setting, 2021

Invasive coinfection by rare fungi during the prehematopoietic stem cell transplant period in a child with acute lymphoblastic leukemia

Contact Info

Product

Resources

About