Successful treatment of Behcet's syndrome with levamisole

Lavery, H.A.; Pinkerton, John

doi:10.1111/j.1365-2133.1985.tb02095.x

Cited by 15 publications

(4 citation statements)

References 2 publications

(1 reference statement)

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“…It has also been examined in several conditions where the stimulant effect on the depressed immune response might be useful [1,2]. Reports in the literature indicate successful treatment with LMS of Behçet's syndrome [3], malignant neoplasms [4], mansonela infections [5], mouth ulceration [6], renal disorders [7], hypopigmentation (vitiligo) [8], etc.…”

Section: Introductionmentioning

confidence: 99%

Enantioseparation of tetramisole by capillary electrophoresis and high performance liquid chromatography and application of these techniques to enantiomeric purity determination of a veterinary drug formulation of L-levamisole

Chankvetadze¹,

Burjanadze

Santi

et al. 2002

J. Sep. Science

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The enantioseparation of the chiral anthelmintic drug tetramisole was studied by capillary electrophoresis using various cyclodextrins as chiral selectors. In particular, the following aspects have been addressed: 1) the enantiomer affinity pattern of tetramisole towards various cyclodextrins; 2) development of a capillary electrophoretic method for quantitative determination of the enantiomeric impurity, i.e. of the R-(+) enantiomer, in S-( -)-tetramisole (levamisole); 3) application of the capillary electrophoretic method for the determination of the enantiomeric impurity of R-(+)-tetramisole in commercial samples and in a veterinary drug formulation of S-( -)-tetramisole; and 4) comparison of capillary electrophoretic and traditional pharmacopoeial polarimetric methods for the enantiomeric impurity determination in S-( -)-tetramisole. Opposite affinity order of tetramisole enantiomers was observed towards different cyclodextrins, depending on the nature of the substituents and the substitution pattern. In addition, an enantioseparation of tetramisole was developed by high performance liquid chromatography on polysaccharide type chiral stationary phase. This method was compared to the aforementioned capillary electrophoretic method. Preliminary validation results indicated that capillary electrophoresis represents a flexible, fast, and inexpensive technique for determination of the enantiomeric impurity of R-(+)-tetramisole in the commercial samples and drug formulations of S-( -)-tetramisole (levamisole). Both of the commercial samples as well as the veterinary drug formulation of levamisole contained R-(+)-tetramisole as enantiomeric impurity. Capillary electrophoresis represents a superior method for enantiomeric impurity determinations compared to the traditional polarimetric method still used in the major pharmacopoeias. CE offers the advantages of miniaturised techniques, as well as higher peak efficiency, flexibility, and shorter method development time compared to HPLC.

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Section: Introductionmentioning

confidence: 99%

Enantioseparation of tetramisole by capillary electrophoresis and high performance liquid chromatography and application of these techniques to enantiomeric purity determination of a veterinary drug formulation of L-levamisole

Chankvetadze¹,

Burjanadze

Santi

et al. 2002

J. Sep. Science

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“…Levamisole is an antihelminthic drug which also has immunomodulatory properties. The latter action has been used in the treatment of a variety of dermatological and other disorders 1–8 . The drug is safe and has minor side‐effects; the serious adverse effect of agranulocytosis is fortunately rare 9,10…”

mentioning

confidence: 99%

A randomized placebo-controlled double-blind study of levamisole in the treatment of limited and slowly spreading vitiligo

Agarwal¹,

Ramam²,

Sharma³

et al. 2005

Br J Dermatol

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“…Better results have been obtained when corticosteroids are combined with immunosuppressive agents, particularly chlorambucil (Inaba & Aoyama, 1982), The recently reported value of levamisole (Lavery & Pinkerton, 1985;de Merieux, Spitler & Paulus, 1981) and acyclovir (Prieto, Suarez & Civeira, 1984;Resegotti & Pistone, 1984) in Behget's syndrome needs further evaluation. Better results have been obtained when corticosteroids are combined with immunosuppressive agents, particularly chlorambucil (Inaba & Aoyama, 1982), The recently reported value of levamisole (Lavery & Pinkerton, 1985;de Merieux, Spitler & Paulus, 1981) and acyclovir (Prieto, Suarez & Civeira, 1984;Resegotti & Pistone, 1984) in Behget's syndrome needs further evaluation.…”

Section: Discussionmentioning

confidence: 99%

Thalidomide in the treatment of neuro-Behcet's syndrome

1986

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No relapses of symptoms in a patient with neuro-Behçet's syndrome were observed after the addition of thalidomide to chlorambucil and prednisolone therapy. At present, the patient has been free of symptoms for 3 years. This observation, together with those reported from the literature, strongly support a re-evaluation of thalidomide therapy in certain life-threatening diseases such as neuro-Behçet's syndrome.

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Successful treatment of Behcet's syndrome with levamisole

Cited by 15 publications

References 2 publications

Enantioseparation of tetramisole by capillary electrophoresis and high performance liquid chromatography and application of these techniques to enantiomeric purity determination of a veterinary drug formulation of L-levamisole

Enantioseparation of tetramisole by capillary electrophoresis and high performance liquid chromatography and application of these techniques to enantiomeric purity determination of a veterinary drug formulation of L-levamisole

A randomized placebo-controlled double-blind study of levamisole in the treatment of limited and slowly spreading vitiligo

Thalidomide in the treatment of neuro-Behcet's syndrome

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