Successful Treatment of Acute Radiation Proctitis with <i>Aloe Vera</i>: A Preliminary Randomized Controlled Clinical Trial

Sahebnasagh, Adeleh; Ghasemi, Arash; Âkbari, Jafar; Alipour, Abbas; Lashkardoost, Hossein; Ala, Shahram; Salehifar, Ebrahim

doi:10.1089/acm.2017.0047

Cited by 28 publications

(29 citation statements)

References 26 publications

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“…Radiation of the pelvic area may cause acute radiation proctitis (ARP) in up to 50% of patients and can present with a variety of symptoms including pain, abdominal cramping, diarrhea, and rectal bleeding [2]. In a 2017 randomized, double-blind, prospective, placebo-controlled trial, the use of aloe vera was evaluated revealing successful treatment of acute radiation proctitis.…”

Section: Proctitismentioning

confidence: 99%

“…In a 2017 randomized, double-blind, prospective, placebo-controlled trial, the use of aloe vera was evaluated revealing successful treatment of acute radiation proctitis. The study enrolled 20 patients, 9 in the aloe group and 11 in the placebo group, and all experienced ARP [2].…”

Section: Proctitismentioning

confidence: 99%

“…Aloe vera, or aloe barbadensis, is a herbal substance part of the Liliaceal family, which contains over 300 species [1]. Aloe vera is commonly known for its topical use in the treatment of burn injuries due to anti-inflammatory, antioxidant, and antibacterial properties [2,3]. The mechanism of action for aloe vera is not fully known, however it is speculated that inhibition of cyclooxygenase may play a role [2,4].…”

Section: Introductionmentioning

confidence: 99%

“…Aloe vera is commonly known for its topical use in the treatment of burn injuries due to anti-inflammatory, antioxidant, and antibacterial properties [2,3]. The mechanism of action for aloe vera is not fully known, however it is speculated that inhibition of cyclooxygenase may play a role [2,4]. Inhibition of cyclooxygenase may contribute to aloe vera's anti-inflammatory and antioxidant properties and as such it has the ability to treat burns and accelerate wound healing [2].…”

Section: Introductionmentioning

confidence: 99%

“…The mechanism of action for aloe vera is not fully known, however it is speculated that inhibition of cyclooxygenase may play a role [2,4]. Inhibition of cyclooxygenase may contribute to aloe vera's anti-inflammatory and antioxidant properties and as such it has the ability to treat burns and accelerate wound healing [2]. Aloe vera may also play a role in leukocyte and platelet aggregation causing a decrease in vasoconstriction, which also contributes to wound healing [3].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The use of aloe vera in cancer radiation: An updated comprehensive review

Farrugia

Burke

Haley

et al. 2019

Complementary Therapies in Clinical Practice

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Introduction: Many cancer patients require radiation therapy and often experience adverse effects including erythema, itching, and pain. Aloe vera has been studied for its potential use in the prevention and treatment of radiation related adverse effects as it possesses a variety of properties and is considered an antioxidant and anti-inflammatory agent. Multiple controlled trials have been performed in order to evaluate the efficacy of aloe vera for the prevention and treatment of radiation side effects. Previous systematic reviews have examined the use of aloe vera for radiation-induced skin reactions, however updated literature now includes the use of aloe vera in proctitis. Objectives: The aim of this comprehensive review is to summarize and evaluate the use of aloe vera in patients who have undergone radiation therapy for the treatment of cancer. Results: Aloe vera may not be effective for prophylaxis or treatment of radiation adverse effects in breast cancer patients. Moderate efficacy was seen when aloe vera was used in combination with mild soap versus soap as monotherapy for the treatment of radiation skin reactions. Aloe vera may be effective when cumulative radiation doses are greater than 2,700cGy and for acute radiation proctitis. Conclusions: There is contradictory evidence for the use of aloe vera in the setting of radiation in regards to its efficacy in the prevention and treatment of radiation-induced adverse effects. Disciplines Disciplines Pharmacy and Pharmaceutical Sciences Comments Comments

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Section: Proctitismentioning

confidence: 99%

Section: Proctitismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The use of aloe vera in cancer radiation: An updated comprehensive review

Farrugia

Burke

Haley

et al. 2019

Complementary Therapies in Clinical Practice

View full text Add to dashboard Cite

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Aloe vera (L.) Burm.f. (Asphodelaceae/Xanthorrhoeaceae)

Akbar

2020

Handbook of 200 Medicinal Plants

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Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines

Bowen

Gibson

Coller

et al. 2019

Support Care Cancer

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The aim of this study was to update the clinical practice guidelines for the use of agents for the prevention and/or treatment of gastrointestinal mucositis (GIM). Methods A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: Recommendation, Suggestion, and No Guideline Possible. Results A total of 78 papers across 13 interventions were examined of which 25 were included in the final review. No new guidelines were possible for any agent due to inadequate and/or conflicting evidence. Existing guidelines for probiotics and hyperbaric oxygen were unchanged. Conclusions Of the agents studied for the prevention and treatment of GIM, the evidence continues to support use of probiotics containing Lactobacillus spp. for prevention of chemoradiotherapy and radiotherapy-induced diarrhea in patients with pelvic malignancy, and hyperbaric oxygen therapy to treat radiation-induced proctitis. Additional well-designed research is encouraged to enable a decision regarding palifermin, glutamine, sodium butyrate, and dietary interventions, for the prevention or treatment of GIM.

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Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial

Abstract: A substantial number of patients with radiation proctitis seem to benefit from therapy with Aloe vera 3% ointment.

Cited by 28 publications

References 26 publications

The use of aloe vera in cancer radiation: An updated comprehensive review

The use of aloe vera in cancer radiation: An updated comprehensive review

Aloe vera (L.) Burm.f. (Asphodelaceae/Xanthorrhoeaceae)

Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines

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