Successful Treatment of a Recurrent Wide Tracheoesophageal Fistula With a Bioabsorbable Patch

Battistella, Lucia; Marulli, Giuseppe; Comacchio, Giovanni Maria; Mammana, Marco; Gregorio, Guido Di; Rea, Federico

doi:10.1016/j.athoracsur.2015.11.038

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…Heatmap representing the proportion of publications by year that utilized specific translational research methodologies from construct characterization to human trial to investigate laryngeal tissue engineering 85‐87,91,92,94,96,97,198‐306 …”

Section: Discussionmentioning

confidence: 99%

Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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While tissue engineering holds significant potential to address current limitations in reconstructive surgery of the head and neck, few constructs have made their way into routine clinical use. In this review, we aim to appraise the state of head and neck tissue engineering over the past five years, with a specific focus on otologic, nasal, craniofacial bone, and laryngotracheal applications. A comprehensive scoping search of the PubMed database was performed and over 2000 article hits were returned with 290 articles included in the final review. These publications have addressed the hallmark characteristics of tissue engineering (cellular source, scaffold, and growth signaling) for head and neck anatomical sites. While there have been promising reports of effective tissue engineered interventions in small groups of human patients, the majority of research remains constrained to in vitro and in vivo studies aimed at furthering the understanding of the biological processes involved in tissue engineering. Further, differences in functional and cosmetic properties of the ear, nose, airway, and craniofacial bone affect the emphasis of investigation at each site. While otolaryngologists currently play a role in tissue engineering translational research, continued multidisciplinary efforts will likely be required to push the state of translation towards tissue‐engineered constructs available for routine clinical use. Level of Evidence NA.

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Section: Discussionmentioning

confidence: 99%

Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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“…In general, surgical approaches are considered the first choice and several techniques have been reported using local tissue, 1 , 2 local flaps 3 , 4 or distant grafts 5 , 6 , 7 , 8 as well as bioabsorbable or fascia tissues. 9 , 10 , 11 Nevertheless, there is a high rate of recurrence. 12 Self‐expendable covered esophageal stents have been described in malignant TEF with a limited life expectance but these stents are not recommended in nonmalignant fistulas as a permanent option.…”

Section: Introductionmentioning

confidence: 99%

“…Persisting tracheoesophageal fistulas (TEF) after laryngectomy and radiation are a therapeutic challenge (Figure 1, Video 1). In general, surgical approaches are considered the first choice and several techniques have been reported using local tissue, 1,2 local flaps 3,4 or distant grafts 5–8 as well as bioabsorbable or fascia tissues 9–11 . Nevertheless, there is a high rate of recurrence 12 .…”

Section: Introductionmentioning

confidence: 99%

Treatment of tracheoesophageal fistulas following laryngectomy by customized prostheses—A bicentric case series

Herzog

Plößl

Grafmans

et al. 2023

Laryngoscope Investig Oto

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Objective Tracheoesophageal fistulas (TEF) following laryngectomy cause immense restrictions due to the inability of oral feeding, loss of voice rehabilitation, penetration of saliva, and permanent need of inflatable tracheal cannulas. Patients are consistently in threat of fatal aspiration pneumonias. The failure rate of surgical approaches to close the fistulas is high and an ultima ratio option by customized silicone prostheses can be considered. Methods A retrospective analysis of 26 patients with a TEF was performed. Results The fistulas occurred in average 40 months after laryngectomy caused by an enlargement of the voice fistula in 17 patients and problems in wound healing in 6 patients. The mean diameter of the fistula was 32 × 18 mm. Eight patients were treated by a button‐shaped and 18 by a tube‐shaped prosthesis. Complete oral feeding was possible in 8 and additional feeding by percutaneous endoscopic gastrostomy tube in 16 patients. Voice rehabilitation by voice prostheses was possible in 18 cases. Fifteen patients died in the course of the treatment either due to oncological progression or other reasons. The median follow‐up time of the patients alive was 36 months (max 88 months) with 2.2 protheses replacements in mean (max 11). Conclusion The treatment of TEF by customized prostheses can be considered as an ultima ration option if other approaches had failed. At least, partial oral nutrition and voice rehabilitation as well as protection from aspiration can be achieved in the majority of the patients. Level of Evidence 4—Case series.

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