Successful treatment of a colonic adenocarcinoma in a horse

Roy, Myrella; Parente, Elisabetta; Donaldson, Marilyn; Habecker, Perry L.; Axon, JE

doi:10.2746/042516402776181178

Cited by 11 publications

(9 citation statements)

References 20 publications

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“…In addition, metastases have been reported in bone and the vertebral canal (Jann et al 2009), adrenal gland, mesentery and urethra (Spoormakers et al 2001). Usually, metastasis has already occurred by the time of post-mortem diagnosis (Roy et al 2002). This report describes metastatic and nonmetastatic IACs in three mature ponies including one case with a novel primary site.…”

Section: Introductionmentioning

confidence: 89%

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Intestinal adenocarcinoma in ponies: Clinical and pathological findings

Völker¹,

Puschmann

Michutta

et al. 2017

Equine Veterinary Education

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Summary Intestinal adenocarcinomas (IACs) are rarely described in horses, particularly in ponies. Here, the clinical and pathomorphological findings of three mature ponies with IACs are reported. All animals had a history of recurrent colic, and displayed hyperfibrinogenaemia. Clinical investigations could not confirm intestinal neoplasia. On gross post‐mortem examination, papillary colonic neoplastic masses partially obliterated the intestinal lumen. In two cases, metastases were present. Histologically, IACs were classified as tubulo‐acinar subtypes with occasional stromal osseous metaplasia. In one case, prestenotic impaction had resulted in rupture of the colon with secondary septic peritonitis. In mature ponies suffering from recurrent colic intestinal neoplasia should be considered as a differential diagnosis.

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Section: Introductionmentioning

confidence: 89%

“…Usually, metastasis has already occurred by the time of post‐mortem diagnosis (Roy et al . ). This report describes metastatic and nonmetastatic IACs in three mature ponies including one case with a novel primary site.…”

Section: Introductionmentioning

confidence: 97%

Intestinal adenocarcinoma in ponies: Clinical and pathological findings

Völker¹,

Puschmann

Michutta

et al. 2017

Equine Veterinary Education

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“…Faecal analysis may reveal the presence of C perfringens exotoxins and C difficile toxins A/B in patients with intestinal neoplasia (with or without diarrhoea), presumably due to necrotic foci in the intestinal mass. Therefore, efforts should be made to rule out intestinal neoplasia (ultrasound, rectal palpation, abdominocentesis) when clostridial exotoxins are positively identified on a faecal analysis, particularly if the history and clinical signs are suggestive of a neoplastic process (weight loss, melaena, haematochezia) (Roy and others 2002). …”

Section: Clostridial Enterocolitismentioning

confidence: 99%

Clostridial diseases of the horse

South¹

2014

In Practice

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The Clostridium genus contains several species that are important equine pathogens. Clostridia are Gram-positive spore-forming bacteria with differing degrees of aerotolerance. Many Clostridium species are intestinal commensals in healthy horses; however, some are opportunistic pathogens that cause a range of diseases. Clostridial spores are often resistant to disinfectants and can survive in extreme environmental conditions, leading to widespread exposure risk. This article describes the main clostridial diseases affecting horses, discussing differential diagnoses, prevention and treatment.

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“…) and intermittent haematochezia (Roy et al . ) are reported. Intestinal neoplasia remains a challenging diagnosis (Taylor et al .…”

Section: Introductionmentioning

confidence: 99%

“…Intestinal adenomatous polyposis and adenocarcinoma are rare neoplastic conditions in horses and have been reported to affect the small intestine (Honnas et al 1987;Patterson-Kane et al 2000;Taylor et al 2006;Moran et al 2008), caecum (Kirchhof et al 1996;Spoormakers et al 2001) and colon (Kirchhof et al 1996;Harvey-Micay 1999;Roy et al 2002;Taylor et al 2006). Presenting complaints most frequently comprise acute and chronic colic (Honnas et al 1987;Harvey-Micay 1999;Roy et al 2002;Moran et al 2008) due to partial obstruction of the intestinal lumen. Less commonly, proteinlosing enteropathy, chronic diarrhoea (Kirchhof et al 1996;Patterson-Kane et al 2000), anorexia, weight loss (Kirchhof et al 1996) and intermittent haematochezia (Roy et al 2002) are reported.…”

Section: Introductionmentioning

confidence: 99%

Calcitonin as a potential tumour marker for medullary thyroid carcinoma in an 11‐year‐old Spanish Pure Bred gelding with two independent carcinomas

Dittus

Hahn

Stokar-Regenscheit

et al. 2017

Equine Veterinary Education

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Summary An 11‐year‐old Spanish Pure Bred gelding was evaluated for progressive weight loss and exercise intolerance. An ante‐mortem biopsy and post‐mortem histopathological examination of the duodenum revealed a duodenal adenocarcinoma. Furthermore, a medullary thyroid carcinoma of the left thyroid gland and multiple bilateral follicular thyroid adenomas were diagnosed post‐mortem. Serum concentration of calcitonin in this case was markedly increased in comparison to two breed and age matched control horses. This case report shows the rare and independent occurrence of two different types of carcinomas in one horse and highlights the diagnostic value of calcitonin measurements for diagnosis of medullary thyroid carcinoma in horses.

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Successful treatment of a colonic adenocarcinoma in a horse

Cited by 11 publications

References 20 publications

Intestinal adenocarcinoma in ponies: Clinical and pathological findings

Intestinal adenocarcinoma in ponies: Clinical and pathological findings

Clostridial diseases of the horse

Calcitonin as a potential tumour marker for medullary thyroid carcinoma in an 11‐year‐old Spanish Pure Bred gelding with two independent carcinomas

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