Successful Surgical Treatment of Renal Cell Carcinoma in a Transplanted Kidney from a Cadaveric Donor: Report of a Case

Gunji, Yoshio; Sakamoto, Kaoru; Yamada, Kenichi; Hamaguchi, K; Kashiwabara, Hidehiko; Hori, Seiji; Shimada, Hideaki; Suzuki, Takao; Ochiai, Takenori

doi:10.1007/s005950170165

Cited by 25 publications

(11 citation statements)

References 7 publications

(8 reference statements)

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“…CT did not show any evidence of a tumor in the grafted kidney. Similarly, there is a case report in the literature of a patient followed by US after transplantation who developed a rapidly invasive RCC that required total nephrectomy (8). In selected patients, NSS seems to be a safe procedure that allows an acceptable quality of life, avoiding immediate dialysis.…”

Section: Discussionmentioning

confidence: 93%

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Renal Cell Carcinoma in Kidney Allografts: A Case Series from a Single Center

Barama

St-Louis

Nicolet

et al. 2005

American Journal of Transplantation

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In kidney transplant recipients, renal cell carcinoma (RCC) occurs either in the native kidney or, less frequently, in the grafted kidney. Here, we report a series of rare cases involving 5 patients from a single center who developed RCC in their grafts. The diagnosis was made serendipitously by ultrasound. The time lapse post-transplant varied from 4 to 17 years. Surgical treatment consisted of nephron-sparing surgery (NSS) in four cases and a secondary radical nephrectomy in one case. All tumors were less than 4 cm in diameter. The histopathology was clear cell type in four cases and papillary RCC in one case. Patients treated by NSS retained kidney function for 2 years or more, and none of them presented early neoplasia recurrence. In conclusion, NSS can be performed safely in grafted kidneys to treat incidental RCC. It prevents an immediate return to dialysis for patients.

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Section: Discussionmentioning

confidence: 93%

“…Multiple case reports have mentioned its feasibility in transplant kidneys (3,4). Similarly, there is a case report in the literature of a patient followed by US after transplantation who developed a rapidly invasive RCC that required total nephrectomy (8). Periodic imaging had been suggested in tumors less than 3 cm in diameter (7).…”

Section: Discussionmentioning

confidence: 99%

Renal Cell Carcinoma in Kidney Allografts: A Case Series from a Single Center

Barama

St-Louis

Nicolet

et al. 2005

American Journal of Transplantation

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“…Characteristics of de novo kidney allograft RCCs is currently unknown. The first case of a de novo tumor arising in a transplanted kidney was reported in 1988 by Scott (7), then 42 cases were described in 35 international publications excluding French reports (4,8–41). These publications were mostly case reports or small series that did not exceed five cases.…”

Section: Discussionmentioning

confidence: 99%

“…DNA analysis could be useful to distinguish the origin of the tumor between the renal allograft and the native kidneys as described by Lotan (29). Gunji (20) suggested that de novo kidney graft cancer may develop rapidly after transplantation, as their case was diagnosed after only 9 months. The natural history of independent tumors is difficult to define, particularly in an immunodepressed patient.…”

Section: Discussionmentioning

confidence: 99%

De Novo Kidney Graft Tumors: Results From a Multicentric Retrospective National Study

Tillou

Doerfler

Collon

et al. 2012

American Journal of Transplantation

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De novo tumors in renal allografts are rare and their prevalence is underestimated. We therefore analyzed renal cell carcinomas arising in renal allografts through a retrospective French renal transplant cohort. We performed a retrospective, multicentric survey by sending questionnaires to all French kidney transplantation centers. All graft tumors diagnosed after transplantation were considered as de novo tumors. Thirty-two centers participated in this study. Seventy-nine tumors were identified among 41 806 recipients (Incidence 0.19%). Patients were 54 men and 25 women with a mean age of 47 years old at the time of diagnosis. Mean tumor size was 27.8 mm. Seventy-four (93.6%), 53 (67%) and 44 tumors (55.6%) were organ confined (T1-2), low grade (G1-2) and papillary carcinomas, respectively. Four patients died of renal cell carcinomas (5%). The mean time lapse between transplantation and RCC diagnosis was 131.7 months. Thirty-five patients underwent conservative surgery by partial nephrectomy (n = 35, 44.3%) or radiofrequency (n = 5; 6.3%). The estimated 5 years cancer specific survival rate was 94%. Most of these tumors were small and incidental. Most tumors were papillary carcinoma, low stage and low grade carcinomas. Conservative treatment has been preferred each time it was feasible in order to avoid a return to dialysis.

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“…3 Options for treating renal transplants containing RCC have included surgical en bloc removal of the transplant with discontinuation of immunosuppression. [5][6][7][8][9][10] Typically, en bloc removals have been performed for tumors larger than 4.5 cm in diameter; however, in 1 case the transplant was removed for chronic pyelonephritis, and histologic analysis showed a 1-cm RCC arising in a cyst. 10 More recently, to preserve the function of a solitary or transplanted kidney, partial nephrectomy with a nephron-sparing operation has been used.…”

Section: Discussionmentioning

confidence: 99%

Sonographically Guided Percutaneous Radio Frequency Ablation of a Renal Cell Carcinoma in a Transplanted Kidney

Charboneau

O'Loughlin

Milliner

et al. 2002

Journal of Ultrasound in Medicine

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adio frequency ablation is an effective treatment for focal renal cell carcinoma (RCC).1,2 We report a patient with RCC in a transplanted kidney that was successfully treated with percutaneous sonographically guided radio frequency ablation.Received June 11, 2002, Case ReportA 50-year-old man had a cadaveric renal transplant in 1975 after a failed living related renal transplant 1 year earlier. The donor organ was from a 20-year-old male trauma victim. For more than 24 years, the patient had excellent renal allograft function, with a serum creatinine level ranging between 0.9 and 1.1 mg/dL (reference range, 0.89-1.2 mg/dL). In 1999, the patient's serum creatinine level began to increase gradually to 1.5 mg/dL. Also, his creatinine clearance rate declined from 109 mL/min per 1.73 m 2 in 1997 to 54 ml/min per 1.73 m 2 in 2001. During this period, he had myocardial infarction and several episodes of congestive heart failure. Despite coronary angioplasty and stenting, the patient still had baseline exertional angina and poor cardiac output.At our institution, initial evaluation of the allograft included a renal sonographic examination that showed renal artery stenosis and a 2.2-cm solid renal mass indicative of RCC (Fig. 1). The mass was further confirmed with contrast-enhanced magnetic resonance imaging (MRI; Fig. 2). The MRI and sonographic examinations showed no evidence of metastatic disease. Because of the need for tissue diagnosis, percutaneous

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Successful Surgical Treatment of Renal Cell Carcinoma in a Transplanted Kidney from a Cadaveric Donor: Report of a Case

Cited by 25 publications

References 7 publications

Renal Cell Carcinoma in Kidney Allografts: A Case Series from a Single Center

Renal Cell Carcinoma in Kidney Allografts: A Case Series from a Single Center

De Novo Kidney Graft Tumors: Results From a Multicentric Retrospective National Study

Sonographically Guided Percutaneous Radio Frequency Ablation of a Renal Cell Carcinoma in a Transplanted Kidney

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