Abstract:Paradoxical embolism (PDE) occurs after embolic material passes from the venous to the arterial circulation through a right-to-left shunt, which is frequently a patent foramen ovale (PFO). We describe the case of a patient with deep venous thrombosis and an intracardiac thrombus straddling a PFO and who was successfully treated with an emergency surgery.
“…Some strokes of unknown origin may be caused by paradoxical embolism due to PFO (1). Although observing a thrombus straddling the PFO is difficult, some cases are detected by echocardiography (6)(7)(8)(9)(10)(11). In the present case, we considered there to be a high possibility of tumor embolism rather than thromboembolism, including Trousseau syndrome.…”
An 82-year-old woman with a history of bladder cancer presented with dyspnea and loss of consciousness. Contrast-enhanced computed tomography revealed pulmonary embolism, and emergency thrombus aspiration therapy was performed, but the thrombus was not aspirated. Echocardiography showed mobile masses in the heart and a right-to-left shunt due to a patent foramen ovale (PFO). Magnetic resonance imaging showed multiple cerebral infarctions. Surgical thrombectomy and PFO closure were performed, and the patient was diagnosed with intracardiac metastasis of bladder cancer based on intraoperative histopathology. This is a rare case of concomitant pulmonary and cerebral tumor embolism and intracardiac metastasis from bladder cancer.
“…Some strokes of unknown origin may be caused by paradoxical embolism due to PFO (1). Although observing a thrombus straddling the PFO is difficult, some cases are detected by echocardiography (6)(7)(8)(9)(10)(11). In the present case, we considered there to be a high possibility of tumor embolism rather than thromboembolism, including Trousseau syndrome.…”
An 82-year-old woman with a history of bladder cancer presented with dyspnea and loss of consciousness. Contrast-enhanced computed tomography revealed pulmonary embolism, and emergency thrombus aspiration therapy was performed, but the thrombus was not aspirated. Echocardiography showed mobile masses in the heart and a right-to-left shunt due to a patent foramen ovale (PFO). Magnetic resonance imaging showed multiple cerebral infarctions. Surgical thrombectomy and PFO closure were performed, and the patient was diagnosed with intracardiac metastasis of bladder cancer based on intraoperative histopathology. This is a rare case of concomitant pulmonary and cerebral tumor embolism and intracardiac metastasis from bladder cancer.
“…Passage of an embolus through a PFO is far more common than a TSPFO. TSPFO may be associated with a pulmonary embolism (94%) or, less commonly, a PDE (44%) 2. In the presence of massive PE, the risk of PDE increases due to the transient increase in right atrial pressure 3.…”
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