Successful Suppression of Drug-Resistant <i>Helicobacter pylori</i> Infection With Bismuth Subsalicylate

Geng, Calvin; Prokesch, Bonnie C; Vemulapalli, Roopa

doi:10.1093/ofid/ofac165

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Recently, Geng et al reported a successful suppression with bismuth subsalicylate given in monotherapy of a drug-resistant H. pylori strain [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

A Simplified Low-Dose 10-Day Quadruple Therapy with a Galenic Formulation of Bismuth Salicylate Is Highly Effective for Helicobacter pylori Eradication

Dore

Saba

Zanni

et al. 2023

JCM

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Background: Earlier studies have shown that a modified low-dose bismuth quadruple therapy given for 10 to 14 days is highly effective for the treatment of Helicobacter pylori infection in Sardinia. However, bismuth is not universally available. Aim: We aimed to investigate the efficacy of a simplified low-dose 10-day quadruple therapy containing a galenic formulation of bismuth salicylate for H. pylori infection. Patients and Methods: Adult patients positive for H. pylori infection were assigned to a quadruple therapy containing a galenic formulation of bismuth salicylate (200 mg) plus tetracycline 500 mg, metronidazole 500 mg and rabeprazole 20 mg, given twice a day with the midday and evening meals for 10 days. A negative stool antigen test or 13C-Urea Breath Test defined successful eradication. Compliance and adverse events were recorded 30–40 days after the end of treatment. Results: In this open-label pilot study, 42 patients were enrolled (mean age 54.1 ± 12.0 years; 64% female). Among the study participants, 35 were naïve to H. pylori treatment. The treatment regimen was completed by 41 patients, with an overall success rate of 95.1%. More specifically, the eradication rate was 95.1% PP; 95% confidence interval (CI) = 86.6–100 and 92.9% by ITT; 95%CI = 85.1–100%, respectively. For naïve patients, the cure rate was 97.1%. Compliance was excellent. Side effects were absent or mild overall. Conclusions: The modified low-dose 10-day quadruple therapy provided high eradication rates of H. pylori infection, despite the replacement of colloidal bismuth subcitrate with bismuth salicylate. In regions where bismuth is unavailable in the market, the galenic formulation should be a valid option.

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“…Recently, Geng et al reported a successful suppression with bismuth subsalicylate given in monotherapy of a drug-resistant H. pylori strain [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

A Simplified Low-Dose 10-Day Quadruple Therapy with a Galenic Formulation of Bismuth Salicylate Is Highly Effective for Helicobacter pylori Eradication

Dore

Saba

Zanni

et al. 2023

JCM

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show abstract

“…To the EDITOR—I read with great interest the publication by Geng et al [ 1 ] on their serendipitous observation that bismuth subsalicylate suppressed gastric infection in a patient with drug-resistant Helicobacter pylori. The purpose of this communication is to consider which of the components of the combination, or both, might be responsible for the efficacy of bismuth subsalicylate.…”

mentioning

confidence: 99%

Suppression of Helicobacter pylori Infection With Bismuth Subsalicylate: Was It the Bismuth or the Salicylate?

Kunin

2022

Open Forum Infectious Diseases

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Multiple drugs

2022

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Successful Suppression of Drug-Resistant Helicobacter pylori Infection With Bismuth Subsalicylate

Cited by 3 publications

References 7 publications

A Simplified Low-Dose 10-Day Quadruple Therapy with a Galenic Formulation of Bismuth Salicylate Is Highly Effective for Helicobacter pylori Eradication

A Simplified Low-Dose 10-Day Quadruple Therapy with a Galenic Formulation of Bismuth Salicylate Is Highly Effective for Helicobacter pylori Eradication

Suppression of Helicobacter pylori Infection With Bismuth Subsalicylate: Was It the Bismuth or the Salicylate?

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