Successful reversal of transgene silencing in Chlamydomonas reinhardtii
Rémy Beauchemin,
Natacha Merindol,
Elisa Fantino
et al.
Abstract:Chlamydomonas reinhardtii has been successfully engineered to produce compounds of interest following transgene integration and heterologous protein expression. The advantages of this model include the availability of validated tools for bioengineering, its photosynthetic ability, and its potential use as biofuel. Despite this, breakthroughs have been hindered by its ability to silence transgene expression through epigenetic changes. Histone deacetylases (HDAC) are main players in gene expression. We hypothesi… Show more
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