Advanced Cardiac Life Support (ACLS) is an extension of basic life support created to manage patients who experience cardiopulmonary arrest outside the hospital setting. While these guidelines were originally created for community-based emergency services, they were subsequently translated for application in the emergency department and other hospital locations. Given that ACLS has become the mainstay of cardiac arrest management, its algorithms have been adopted for use of patients in the perioperative period. 1 However, cardiac arrest during anesthesia is distinct from that in other settings. Cardiac arrest during anesthesia, although rare, is witnessed and, therefore, may be anticipated. Measures can be taken in advance of circulatory collapse to support a patient's physiology and avoid or delay the need for ACLS. These key differences are associated with better outcomes compared with out-of-hospital or unwitnessed inhospital cardiac arrests. 2,3 This article reviews specific ACLS recommendations and approaches for the management of intraoperative cardiac arrest.
Incidence, outcomes, and causes of intraoperative cardiac arrestIntraoperative cardiac arrest (ICA) in the United States is rare, occurring in ~5 to 6 per 10,000 anesthetic cases. [4][5][6] The European Resuscitation Council finds the incidence of perioperative cardiac arrest to range from 4.3 to 34.6 per 10,000 procedures with a 30day mortality of up to 70%. 7,8 Regarding causation, 1 study notes that of 10,000 ICAs, less than one-0.74-was thought to be directly related to anesthesia. 6 Secondary anesthesia-related causes include hypoxia due to failed airway, loss of airway and/or poor ventilation management, hemodynamic instability due to medication administration and side effects, residual neuromuscular blockade, anaphylaxis, iatrogenic injuries from procedures, and complications from regional and neuraxial blocks. Surgical causes such as hemorrhage and trauma must also be considered. 3,7 The etiology of ICA is often readily apparent during a surgical procedure because an arrest is usually witnessed by clinicians familiar with the patient's medical history, and the precipitating cause may be known and rapidly reversible. Thus, initiation of the treatment is usually timely and focused, resulting in better outcomes in terms of survival or residual neurological deficits compared with arrest in other settings. 3,9 Retrospective studies of patients who experienced ICA show one-third surviving hospital discharge, with good neurological outcomes seen in 55% to 66% of the survivors. 7,10