Successful pregnancy outcome following maternal intravenous immunoglobulin treatment in a woman with recurrent perinatal haemochromatosis

Abstract

Haemochromatosis should be considered in the differential diagnosis of hydrops fetalis. The recurrence risk is high, and immunomodulation with intravenous immunoglobulin treatment appears to alter the course of the disease with better infant survival.

Neonatal Hemochromatosis

“…Others have reported similar success with this approach. [50][51][52][53] The success of this preventative therapy provides the impetus to make a diagnosis in any affected infant and stillbirth, so the family can have a healthy baby in the future.…”

Antenatal Treatment with Intravenous Immunoglobulin to Prevent Gestational Alloimmune Liver Disease: Comparative Effectiveness of 14-Week versus 18-Week Initiation

“…So, in addition to the several possible mechanisms of action cited above for alloimmune thrombocytopenia, inhibition of activation of the terminal complement cascade may be important in the action of antenatal IVIG therapy in GALD. Whatever the mechanism, wide experience suggests that it is effective in limiting the effect of GALD in pregnancies at risk [11,15,[21][22][23][24][25][26][27]. Although the extent of protection from fetal liver injury in GALD cannot be ascertained to the same degree as in alloimmune thrombocytopenia, where the platelet count is a direct measure of effectiveness, the results in the present study clearly demonstrate improved outcomes with IVIG treatment.…”

Traitement anténatal préventif de l’hémochromatose néonatale par administration maternelle d’immunoglobulines intraveineuses (à propos de quatre observations)

“…Parmi les nouveau-né s ayant pré senté une forme atté nué e d'HN, sept ont reçu un traitement mé dical associant ché lateur du fer et antioxydant ; aucun dé cè s n'est survenu. Ce travail a é té , par la suite, complé té par d'autres observations [27][28][29]. Dans notre é tude, deux nouveau-né s ont pré senté une forme biologique de la maladie, transitoire.…”