Successful Pregnancy following Busulfan and Cyclophosphamide Conditioning and Allogeneic Bone Marrow Transplantation for Chronic Myeloid Leukemia

Live birth with vitrified-warmed oocytes of a chronic myeloid leukemia patient nine years after allogenic bone marrow transplantation

“…Generally, most patients subjected to TBI use gestational carriers for pregnancy [18], due to problems, such as miscarriage, midtrimester pregnancy loss, preterm birth, and low birthweight [19]. However, bearing in mind the few successful pregnancies reported after TBI and BMT [20][21][22], we decided not to use a gestational carrier. In our case, preterm birth was due to severe preeclampsia and not preterm labor.…”

Twin Pregnancy and Childbirth after Reduced-intensity Conditioning Allogeneic Haematopoietic Stem Cell Transplantation Combined with Imatinib Mesylate for Chronic Myeloid Leukaemia: Case Report and Literature Review

“…13 There have been only two reported cases of successful pregnancy after busulphan and cyclophosphamide conditioning: one CML patient and one case of thalassaemia. 20,21 The majority of patients given total body irradiation-conditioning also experience gonadal failure. Recovery of gonadal function occurs in 10 -13.5% of female patients, and the incidence of pregnancy reported by one centre was 1.3%.…”

Repeated Spontaneous Pregnancies and Successful Deliveries After Repeated Autologous Stem Cell Transplantation and GnRH-Agonist Treatment

“…Thus, theoretically, according to their findings, the estimated odds for spontaneous conception after two SCTs are 0.03 ϫ 0.03 ϭ 0.0009, which is Ͻ1: 1,000. Although several reports on spontaneous conceptions and deliveries after SCT have been published [7], we are not aware of any publication of repeated successful deliveries after repeated SCT in the same patient. To the best of our knowledge, this is the first case.…”