Successful pregnancy and delivery from frozen-thawed embryos after intracytoplasmic sperm injection using round-headed spermatozoa and assisted oocyte activation in a globozoospermic patient with mosaic down syndrome

Kim, Sung Tae; Beom, Young; Park, Jong Min; Gye, Myung Chan

doi:10.1016/s0015-0282(00)01698-8

Cited by 86 publications

(61 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Calcium ionophore, for example, is very commonly used for chemical activation of oocytes. Whereas the safety of artificial oocyte activation with calcium ionophores remains controversial, its application to a patient with globozoospermia resulted in a successful pregnancy [35]. Moreover, another case study on globozoospermia associated with a lack of PLC zeta reported that artificial oocyte activation with calcium ionophores successfully overcame repeated fertilization failures [36].…”

Section: Discussionmentioning

confidence: 99%

Analysis of clinical outcomes with respect to spermatozoan origin after artificial oocyte activation with a calcium ionophore

Yoon

Bae

Kim

et al. 2013

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose Fertilization failures have occurred repeatedly in reproductive centers after intracytoplasmic sperm injection (ICSI) and artificial oocyte activation (AOA) has been used to prevent it. This study was performed to investigate whether spermatozoan origin influences clinical outcomes of AOAwith a calcium ionophore. Methods A total of 185 ICSI cycles with a history of no or low fertilization was included in this retrospective study. The outcomes of AOA after ICSI were compared with ejaculatednormal, ejaculated-oligo-astheno-terato or extracted-testicular spermatozoa. Results There were significant differences between the previous standard ICSI cycles and AOA cycles in the rate of fertilization and clinical outcomes among cases with different sperm origins. Thirty-eight healthy babies (20 singles and 18 twins, 29 cycles) were successfully delivered, and no congenital birth defects were observed. Conclusions Most patients with a no or low fertilization history obtained an increased fertilization rate and a positive clinical outcome with AOA regardless of the origin of spermatozoa.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of clinical outcomes with respect to spermatozoan origin after artificial oocyte activation with a calcium ionophore

Yoon

Bae

Kim

et al. 2013

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…To date, four live births have been reported from men with Down syndrome [8,[10][11][12]. However, in marked contrast to the experience in women, all four children born to men with trisomy 21 have been normal.…”

Section: Introductionmentioning

confidence: 91%

“…Three conceptions were spontaneous [8,10,11] while one case required intracytoplasmic sperm injection (ICSI) of round-headed sperm obtained by testicular aspiration from a globoazoospermic man mosaic for trisomy 21 [12]. Of the four reported live births, one was in a man with mosaicism [12] and three in non-mosaic men [8,10,11]. In men who are mosaic for trisomy 21, i.e., having two cell lines (46, XY and 47, XY+21), it is hard to determine which cell line predominates within seminiferous tubules and primarily impacts spermatogenesis.…”

Section: Introductionmentioning

confidence: 99%

Birth of a healthy child after preimplantation genetic screening of embryos from sperm of a man with non-mosaic Down syndrome

Aghajanova

Popwell

Chetkowski

et al. 2015

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose The purpose of this study is to present a case of healthy infant born after intracytoplasmic sperm injection-in vitro fertilization (ICSI-IVF) with preimplantation genetic screening (PGS) using sperm from a man with non-mosaic trisomy 21 and a literature review. Materials and methods A 26-year-old euploid female and 29-year-old male with non-mosaic trisomy 21 and male factor undergoing ICSI-IVF treatment for primary infertility with embryo biopsy for PGS with comprehensive chromosomal screening (CCS) presented to the Infertility Clinic at Highland Hospital, the Alameda County Medical Center, California, with 6-year history of primary infertility. The outcome measure is a live birth of a healthy child and ploidy status of biopsied blastocysts. Results Egg retrieval yielded 33 oocytes, 29 of which underwent ICSI with ejaculated sperm. Twenty-eight 2PN zygotes were cultured, and 13 blastocysts underwent trophectoderm biopsy and vitrification 5 or 6 days after retrieval. CCS analysis revealed that 12 out of 13 (92 %) of blastocysts were euploid and one was a complex abnormal mosaic. Transfer of two grade I hatching blastocysts resulted in a singleton pregnancy with normal prenatal genetic screening and delivery of a healthy male infant at 41 weeks via primary cesarean section for non-reassuring fetal status. Conclusion This is the first report of a live birth of a healthy child after ICSI-IVF with PGS using ejaculated sperm from a man with non-mosaic trisomy 21 and male factor infertility.

show abstract

“…There are several studies focusing on different artificial oocyte activation (AOA) techniques. According to some of the previously published data, artificially activated oocytes (either calcium ionophore or electrically) develop similarly to fertilized oocytes [41][42][43][44].…”

Section: Groupsmentioning

confidence: 99%

The Effect of Piezoelectric Stimulation in Patients with Low Fertilization Potential

Ünsal¹

2014

Human Genet Embryol

View full text Add to dashboard Cite

Objective: To assess the value of the electrical activation of oocytes in ICSI patients with previous limited fertilization outcomes.Design: Prospective randomized study. Settings Result(s):Patients were subdivided into six study groups. In Group I, testicular elongated spermatids were used and 27.9% fertilization, 2.3% clinical pregnancy rates were evaluated. In testicular immotile spermatozoa injected group (Group II), 56.5% fertilization and 50% clinical pregnancy rates were obtained. 66.7% fertilization and 30%clinical pregnancy rates were achieved in Group III with testicular motile spermatozoa. In Group IV, patients with severe oligozoospermia, 64% fertilization and 28.6% clinical pregnancy rates were achieved. Group V included patients with total immotile spermatozoa and fertilization and clinical pregnancy rates were 50% and 57.1% respectively. In patients with history of low fertilization rate (Group VI), 38.7% fertilization and 19% clinical pregnancy rates were obtained. Conclusion(s):Piezoelectric stimulation can be used for patients with low fertilization rates and total immotile spermatozoa; as we detected an improvement in the fertilization and clinical pregnancy rates of these patients.

show abstract

Successful pregnancy and delivery from frozen-thawed embryos after intracytoplasmic sperm injection using round-headed spermatozoa and assisted oocyte activation in a globozoospermic patient with mosaic down syndrome

Cited by 86 publications

References 4 publications

Analysis of clinical outcomes with respect to spermatozoan origin after artificial oocyte activation with a calcium ionophore

Analysis of clinical outcomes with respect to spermatozoan origin after artificial oocyte activation with a calcium ionophore

Birth of a healthy child after preimplantation genetic screening of embryos from sperm of a man with non-mosaic Down syndrome

The Effect of Piezoelectric Stimulation in Patients with Low Fertilization Potential

Contact Info

Product

Resources

About