Successful Pregnancy and Delivery after Concomitant Temozolomide and Radiotherapy Treatment of Glioblastoma Multiforme

McGrane, John; Bedford, T. H. B.; Kelly, Stephen

doi:10.1016/j.clon.2012.01.005

Cited by 26 publications

(13 citation statements)

References 5 publications

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“…This corticosteroid treatment may have also helped to reduce brain edema. Also, lamotrigine, levetiracetam and carbamazepine are the safest anticonvulsants in which benefits outweigh the risks of teratogenicity …”

Section: Discussionmentioning

confidence: 99%

“…Also, lamotrigine, levetiracetam and carbamazepine are the safest anticonvulsants in which benefits outweigh the risks of teratogenicity. [10][11][12] Other treatment options include tumor resection, chemotherapy and radiotherapy. Despite the known teratogenicity of chemotherapeutic agents and radiation, McGrane et al 11 reported a successful pregnancy and delivery in a patient with glioblastoma treated with external beam radiotherapy over 6 weeks with concomitant oral 75 mg/m 2 temozolomide daily.…”

Section: Figurementioning

confidence: 99%

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Recurrent brain tumor with hydrocephalus in pregnancy

Taylan

Akdemir

Zeybek

et al. 2014

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Recurrent brain tumor with hydrocephalus in pregnancy

Taylan

Akdemir

Zeybek

et al. 2014

J of Obstet and Gynaecol

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“…Only three reports describe fertility following temozolomide treatment suggesting that temozolomide is not totally gonadotoxic. Patient fathered healthy children after completing temozolomide treatment [7,8]. In 24 women treated with temozolomide for a low-grade glioma, four patients became pregnant [9].…”

Section: Discussionmentioning

confidence: 99%

Effect of temozolomide on male gametes: an epigenetic risk to the offspring?

Berthaut

Montjean

Dessolle

et al. 2013

J Assist Reprod Genet

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Introduction Temozolomide is an oral alkylating agent with proven efficacy in recurrent high-grade glioma. The antitumour activity of this molecule is attributed to the inhibition of replication through DNA methylation. However, this methylation may also perturb other DNA-dependent processes, such as spermatogenesis. The ability to father a child may be affected by having this treatment. Here we report a pregnancy and a baby born after 6 cures of temozolomide. Methods The quality of gametes of the father has been studied through these cures and after the cessation of treatment. Sperm parameters, chromosomal content and epigenetic profiles of H19, MEST and MGMT have been analysed.Results Sperm counts decrease significantly and hypomethylation of the H19 locus increase with time even staying in the normal range. Conclusion This is the first report of an epigenetic modification in sperm after temozolomide treatment suggesting a potential risk for the offspring. A sperm cryopreservation before the initiation of temozolomide treatment should be recommended.

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Section: Introductionmentioning

confidence: 99%

“…Besides the grim prognosis of malignant gliomas, the actual standard therapy of glioblastoma adversely affects fertility 1 . In fact, radiotherapy aimed at the hypothalamus and the pituitary gland exceeding 45 Gy could impair the synthesis of gonadotropins, while chemotherapy with alkylating agents such as temozolomide is associated with impaired ovarian function leading to premature menopause 1– 3 . However, there are some reports of pregnancies in women with malignant gliomas 1, 4– 11 , describing women whose brain tumors were diagnosed during pregnancy, as well as women who already had undergone treatment for malignant gliomas and who became pregnant afterwards.…”

Section: Introductionmentioning

confidence: 99%

Case Report: Pregnancy in a patient with recurrent glioblastoma

et al. 2013

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We report the case of a woman with relapsed glioblastoma multiforme (GBM) who recently gave birth. She announced her pregnancy shortly after the sixth cycle of a dense regimen of temozolomide, prescribed for treating the first recurrence of glioblastoma. Three years ago, in April 2008, she had undergone gross total resection of a glioblastoma multiforme in the postcentral region of the right hemisphere and had subsequently received treatment according to the actual standard therapy consisting of radiotherapy up to 60 Gy with concomitant and adjuvant temozolomide. The complete amount of temozolomide given before this pregnancy was 20.9 mg/m 2. Nevertheless, she delivered a 1890 g child by caesarean section in the 32/6 week of pregnancy. The child showed no anomalies and is developing normally under close surveillance by paediatricians.

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Successful Pregnancy and Delivery after Concomitant Temozolomide and Radiotherapy Treatment of Glioblastoma Multiforme

Cited by 26 publications

References 5 publications

Recurrent brain tumor with hydrocephalus in pregnancy

Recurrent brain tumor with hydrocephalus in pregnancy

Effect of temozolomide on male gametes: an epigenetic risk to the offspring?

Case Report: Pregnancy in a patient with recurrent glioblastoma

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