Successful Patching of Iatrogenic Rupture of the Fetal Membranes

Lewi, Liesbeth; Schoubroeck, Dominique Van; Ranst, Marc Van; Bries, Greet; Emonds, Marie‐Paule; Arabin, Birgit; Welch, Ross; Deprest, Jan

doi:10.1016/j.placenta.2003.09.003

Cited by 51 publications

(27 citation statements)

References 33 publications

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“…Other authors have reported successful cases with the same or a slightly modified technique (Table II). [45][46][47][48] This "amniopatch" therapy mimics the "blood patch" that is used in cases of spinal headache after iatrogenic cerebrospinal fluid leakage. It is experimentally supported by in vitro experiments that show that platelets adhere to wounded amnion and form a plug that is stabilized subsequently by cryoprecipitate.…”

Section: Use Of Tissue Sealants Human Fetal Membranes Repair: Iatrogementioning

confidence: 99%

Fetal membrane healing after spontaneous and iatrogenic membrane rupture: A review of current evidence

Devlieger

Millar

Bryant‐Greenwood

et al. 2006

American Journal of Obstetrics and Gynecology

123

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In view of the important protective role of the fetal membranes, wound sealing, tissue regeneration, or wound healing could be life saving in cases of preterm premature rupture of the membranes. Although many investigators are studying the causes of preterm premature rupture of membranes, the emphasis has not been on the wound healing capacity of the fetal membranes. In this review, the relevant literature on the pathophysiologic condition that leads to preterm premature rupture of membranes will be summarized to emphasize a continuum of events between rupture and repair. We will present the current knowledge on fetal membrane wound healing and discuss the clinical implications of these findings. We will critically discuss recent experimental interventions in women to seal or heal the fetal membranes after preterm premature rupture of membranes. KeywordsPreterm premature rupture of membranes; Pregnancy outcome Intact fetal membranes during pregnancy are important to the maintenance of amniotic fluid homeostasis and in the defense against ascending infection. Although the association with preterm premature rupture of membranes (PROM) and adverse pregnancy outcomes have been well-described, data regarding the capacity of the fetal membranes for healing and repair remain limited. Multiple potential therapies have been advocated for the treatment of preterm PROM with some success, especially in cases of postprocedural fetal membrane rupture. However, before incorporation in clinical practice, potential therapies should be studied further in animal models and human fetal membrane explants to determine the efficacy and optimal treatment regimens.The amnion, chorion, and contiguous maternal decidua form the human fetal membranes in the second and third trimester of pregnancy. The membranes form an adjustable bio-container * Reprint requests: Roland Devlieger, MD, PhD, Department of Obstetrics and Gynecology, University Hospital Leuven, Herestraat 49, B-3000 Leuven, Belgium. E-mail: roland.devlieger@uz.kuleuven.ac.be. This review discusses human fetal membrane healing by focusing on cause, clinical consequences, and potential therapies to prevent and treat preterm premature rupture of membranes.

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Section: Use Of Tissue Sealants Human Fetal Membranes Repair: Iatrogementioning

confidence: 99%

Fetal membrane healing after spontaneous and iatrogenic membrane rupture: A review of current evidence

Devlieger

Millar

Bryant‐Greenwood

et al. 2006

American Journal of Obstetrics and Gynecology

123

View full text Add to dashboard Cite

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“…Because of the clinical relevance of its consequences, several groups have explored the possibility to treat or prevent iPPROM from happening by sealing the membrane defect. Most research now focuses on using matrices that may improve sealing and stimulate wound healing (Lewi et al, 2004;Mallik et al, 2007;Ochsenbein-Kolble et al, 2007).…”

mentioning

confidence: 99%

On the origin of amniotic stem cells: of mice and men

Dobreva¹,

Pereira²,

Deprest³

et al. 2010

Int. J. Dev. Biol.

135

139

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A common characteristic of mammals is the development of extraembryonic supporting tissues and organs that are required for embryonic implantation, survival and development in utero. The amnion is the innermost extraembryonic membrane that eventually surrounds the fetus of amniotes, and contains the amniotic fluid. Next to its function in in utero development, the amnion has been shown to have an important potential for clinical applications. It is mainly used as a dressing to stimulate healing in skin and ocular wounds. Moreover, cells derived from the amniotic membrane and amniotic fluid have been reported to possess stem cell features, like pluripotent differentiation ability. Little is known about the early development of this membrane in humans. The mouse is a powerful genetic model organism that can be used to address the dynamics and the developmental origin of amnion and amnion-derived stem cells. Here, we discuss some fundamental differences in amnion development in the disc-shaped primate embryo and in the cup-shaped mouse embryo. We emphasize the consequences that this may have on the derivation of amniotic "stem" cells. After revision of the different isolation procedures of amniotic (fluid) derived "stem" cells from rodents, we reveal striking differences in the sources used to derive these cells across studies. The profound differences in the development of the extraembryonic membranes and cavities between primates and rodents may result in comparing cell types of different developmental origins, eventually leading to missinterpretations.

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“…Several methods have been proposed to repair the spontaneous or iatrogenic rupture of membranes (ROM) [6] and these and other techniques have been considered for closure of the endoscopic hole through the membranes after fetal surgery [7,8] . Fetal membranes act as a complexly interacting paracrine system [9] .…”

mentioning

confidence: 99%

Hypothetical Role of Prostaglandins in the Onset of Preterm Labor after Fetal Surgery

2006

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Preterm labor is one of the most important factors limiting the advancement of fetal surgery programs. While prostaglandins (PGs) have long been indicated as the key factor in the initiation of labor in humans, there is significant evidence showing that the chorionic membrane acts as a powerful barrier between the decidua/myometrium and amniotic PGs during normal pregnancy. After either open or endoscopic fetal surgery the imperfect, non-hermetical closure of the chorion permits leakage of PGs from the amnionic sac, allowing them to reach the decidua and myometrium. The surgical wound in the chorionic barrier could be the major factor involved in preterm labor and delivery after human fetal surgery.

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Successful Patching of Iatrogenic Rupture of the Fetal Membranes

Cited by 51 publications

References 33 publications

Fetal membrane healing after spontaneous and iatrogenic membrane rupture: A review of current evidence

Fetal membrane healing after spontaneous and iatrogenic membrane rupture: A review of current evidence

On the origin of amniotic stem cells: of mice and men

Hypothetical Role of Prostaglandins in the Onset of Preterm Labor after Fetal Surgery

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