Successful ongoing pregnancy following cryopreserved-thawed blastocyst transfer in an infertile Kallmann syndrome woman with balanced reciprocal translocation: a case report

Nishiyama, R.; Kitaya, Kotaro; Takaya, Y.; Yamaguchi, Kensei; Kim, N.; Matsubayashi, Hidehiko; Ishikawa, Takahisa

doi:10.12891/ceog4576.2019

Cited by 1 publication

(5 citation statements)

References 5 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Poor ovarian responsiveness to gonadotropin therapy ovulation induction has been reported in IHH patients, including those with Kallmann syndrome 16 , 19) . IHH is a group of disorders that cause idiopathic GnRH deficiency or GnRH hyposecretion.…”

Section: Discussionmentioning

confidence: 99%

“…ART is considered the next treatment option when pregnancy cannot be achieved with gonadotropin therapy or when optimal follicular growth cannot be controlled. Table 2 summarizes the reports on ART treatment for patients with IHH, including those with Kallmann syndrome 14 - 16 , 23 - 31) . Among these, only three reported ART treatments exclusively for patients with Kallmann syndrome 14 - 16) .…”

Section: Discussionmentioning

confidence: 99%

“…Table 2 summarizes the reports on ART treatment for patients with IHH, including those with Kallmann syndrome 14 - 16 , 23 - 31) . Among these, only three reported ART treatments exclusively for patients with Kallmann syndrome 14 - 16) . One was a fresh ET treatment cycle after ICSI 14) , while the other two cases involved a frozen-thawed ET treatment cycle after IVF or ICSI 15 , 16) .…”

Section: Discussionmentioning

confidence: 99%

“…Among these, only three reported ART treatments exclusively for patients with Kallmann syndrome 14 - 16) . One was a fresh ET treatment cycle after ICSI 14) , while the other two cases involved a frozen-thawed ET treatment cycle after IVF or ICSI 15 , 16) . The remaining nine reports included IHH and secondary HH.…”

Section: Discussionmentioning

confidence: 99%

“…In Kallmann syndrome, as with other infertility cases, assisted reproductive technologies (ART), such as in vitro fertilization and embryo transfer (IVF-ET), are the treatments of choice when intercourse and artificial insemination with the husband’s semen, in combination with ovulation induction therapy, do not result in pregnancy. To date, there have been few reports of pregnancies following ART treatment in patients with Kallmann syndrome 14 - 16) . Therefore, at present, there is a lack of evidence regarding the optimal ART treatment for these patients.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Successful pregnancy and delivery after a vitrified-warmed embryo transfer in a woman with Kallmann syndrome: A case report and literature review

Shiraiwa

Takahashi

Okoshi

et al. 2022

FJMS

View full text Add to dashboard Cite

Kallmann syndrome, a congenital disorder of idiopathic hypogonadotropic hypogonadism associated with anosmia, results in infertility because of anovulation. Assisted reproductive technology (ART) is considered when optimal ovulation induction therapy is difficult or when several cycles of ovulation induction therapy do not result in pregnancy. However, evidence is lacking regarding the optimal ART treatment for Kallmann syndrome. We report the case of a 33-year-old woman who successfully achieved pregnancy and delivery after ART treatment. At 29 years old, she was diagnosed with Kallmann syndrome due to hypothalamic amenorrhea and anosmia. At 33 years old, she revisited the hospital, desiring a child after one year of infertility. Due to anovulation, she was treated with gonadotropin therapy, but controlling follicular development was difficult, and thus ART treatment was initiated. The controlled ovarian stimulation (COS) protocol for ART treatment employed gonadotropins, recombinant follicular stimulating hormone/human menopausal gonadotropin plus human chorionic gonadotropin, to promote follicular growth. Four oocytes were retrieved, and two cleaved embryos were vitrified and cryopreserved. After vitrified-warmed embryo transfer of a morula stage embryo in a hormone replacement cycle, pregnancy was achieved but resulted in a miscarriage. A second oocyte retrieval was performed under the same COS; four oocytes were retrieved, and two cleaved embryos were vitrified and cryopreserved. Further, a pregnancy was achieved through the vitrified warmed embryo transfer. At 40 weeks and 6 days of gestation, a baby boy weighing 3,344 g with an Apgar score of 7/8 was delivered vaginally. The mother’s postpartum course and neonate were free from adverse events. For women with Kallmann syndrome, ART treatment and selective embryo cryopreservation may be a reasonable and safe option.

show abstract

Section: Discussionmentioning

confidence: 99%