Successful obstetric and hematologic outcome of aplastic anemia in a pregnant Jehovah’s Witness

Jakiel, Grzegorz; Ciebiera, Michał; Słabuszewska-Jóźwiak, Aneta; Horosz, Bartosz; Bińkowska, Małgorzata; Wilińska, Maria; Malec-Milewska, Małgorzata

doi:10.1177/0394632016656188

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…inadequate time to assess response. The risks of ciclosporin, however, warrant consideration if use is contemplated during pregnancy, particularly as a considerable proportion may be managed with supportive care during pregnancy (Kwon et al , ; Shin et al , ; Bo et al , ; Jakiel et al , ). Discontinuing ciclosporin, however, may result in reduction in platelet counts (Tichelli et al , ).…”

Section: Definitions Of Responsementioning

confidence: 99%

Aplastic anaemia in pregnancy – a single centre, North American series

et al. 2018

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Aplastic anaemia (AA) is infrequently observed in pregnancy. We describe 19 pregnancies in 9 women at a tertiary care centre over a period of 30 years. Spontaneous resolution of AA did not occur postpartum in the five pregnancies where AA was first diagnosed in pregnancy. In the remaining pregnancies, although haematological indices declined and transfusion support was needed in 35% of pregnancies, relapses were not observed. There were no deaths, but complications occurred in 79% of pregnancies. Preterm delivery and postpartum haemorrhage were observed in 21% and 26% of pregnancies, respectively.

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Section: Definitions Of Responsementioning

confidence: 99%

Aplastic anaemia in pregnancy – a single centre, North American series

et al. 2018

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“…Other studies support a clear link between pregnancy and aplastic anaemia, and some reviews even list pregnancy as a contributing factor to aplastic anaemia. 3 Aplastic anaemia is known to cause antenatal complications like spontaneous miscarriage (16.7%), preterm birth (12.1%), intrauterine death (16.7%) and stillbirth (15.1%). 1 The two leading causes of death in pregnant women with aplastic anaemia are haemorrhage and sepsis.…”

Section: Discussionmentioning

confidence: 99%

“…8 Most of the supportive treatments for aplastic anemias related to pregnancy is transfusion of blood products. 3 However, this can result in problems such as hemochromatosis and-more seriously-HLA alloimmunization. Platelet-transfusion refractoriness (PTR) is brought on by alloantibodies against human platelets.…”

Section: Discussionmentioning

confidence: 99%

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Managing aplastic anaemia in pregnancy: a unique obstetric challenge

Makker,

Hebbar,

Lobo

et al. 2024

Int J Reprod Contracept Obstet Gynecol

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Aplastic anaemia during pregnancy poses a unique obstetric challenge due to its rarity and potential life-threatening consequences. This article explores the intricate management of aplastic anaemia in pregnancy through a detailed case report of a 23-year-old primigravida. Despite the absence of clear guidelines, the patient successfully navigated pregnancy with multiple transfusions, presenting a compelling example of obstetric and neonatal success. The discussion digs into the complex relationship between pregnancy and aplastic anaemia, emphasizing the need for a multidisciplinary approach and careful decision-making to balance maternal and foetal well-being. The conclusion highlights the importance of a comprehensive strategy, including vigilant transfusion techniques, foetal growth monitoring, and delivery planning at tertiary centres.

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