Successful microwave ablation of endometrial carcinoma

Sharp, Nicholas; Ellard, Michael; Hirschowitz, Lynn; Malthouse, S.R.; Johnson, Nick

doi:10.1046/j.1471-0528.2002.01081.x

Cited by 18 publications

(5 citation statements)

References 2 publications

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“…For example, it increases brain activity and is involved in oxidative processes in the body. It can also act on the central nervous system to regulate and improve the development and metabolism of neurons, induce the differentiation of neurons, promote the formation of synapses, and protect nerve cells from damage caused by ischemia, hypoxia, and neurotoxins (Sharp, 2002;Keilhoff et al, 2014). In addition, cerebroprotein hydrolysate can affect the respiratory chain by increasing the utilization of oxygen and glucose in the brain, subsequently, increasing the antioxidant capacity of brain tissues and the ability of the body to handle stress, improving energy metabolism in the brain, alleviating damage to brain tissues, and promoting recovery of brain function.…”

Section: Introductionmentioning

confidence: 99%

Effects and mechanism of cerebroprotein hydrolysate on learning and memory ability in mice

Han

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Cerebroprotein hydrolysate is an extract from porcine brain tissue that acts on the central nervous system in various ways to protect neurons and improve memory, attention, and vigilance. This study examined the effect and mechanism of cerebroprotein hydrolysate on learning and memory in mice with scopolamineinduced impairment. Mice were given an intraperitoneal injection of scopolamine hydrobromide to establish a murine model of learning and memory impairment. After 35 successive days of cerebroprotein hydrolysate treatment, their behaviors were observed in the Morris water maze and step-down test. Superoxide dismutase (SOD), Na + -K + -ATPase, and acetylcholinesterase (AChE) activity, and malondialdehyde (MDA), γ-aminobutyric acid (GABA), and glutamic acid (Glu) levels in the brain tissue of the mice were determined, and pathological changes in the hippocampus were examined. The results of the water-maze test showed that cerebroprotein hydrolysate shortened the escape latency and increased the number of platform crossings. In the step-down test, cerebroprotein hydrolysate treatment prolonged the step-down latency and reduced the number of errors; cerebroprotein hydrolysate increased the activity of SOD, Na + -K + -ATPase, and AChE, reduced the levels of MDA, decreased the Glu/GABA ratio in brain tissue, and reduced pathological changes in the hippocampus. The results indicate that cerebroprotein hydrolysate can improve learning and memory in mice with scopolamine-induced impairment. This effect may be associated with its ability to reduce injury caused by free radicals, improve acetylcholine function, and modulate the Glu/GABA learning and memory regulation system, reducing excitotoxicity caused by Glu.

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Section: Introductionmentioning

confidence: 99%

Effects and mechanism of cerebroprotein hydrolysate on learning and memory ability in mice

Han

et al. 2016

Genet. Mol. Res.

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“…MEA guidelines state that suspicion of endometrial malignancy is a contraindication for the use of MEA ( 4 ); however, there is no clear evidence against the use of the procedure in these situations. To the best of our knowledge, MEA has been used only once in an attempt to treat endometrial carcinoma-associated uterine bleeding ( 5 ). In that case report, the authors suggested that MEA may be considered a palliative treatment for elderly women with early endometrial carcinoma who have severe complications and are therefore unfit for standard treatment ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, MEA has been used only once in an attempt to treat endometrial carcinoma-associated uterine bleeding ( 5 ). In that case report, the authors suggested that MEA may be considered a palliative treatment for elderly women with early endometrial carcinoma who have severe complications and are therefore unfit for standard treatment ( 5 ). In the current case series, emergency control of uterine hemorrhage caused by endometrial carcinoma in two patients was achieved using MEA.…”

Section: Discussionmentioning

confidence: 99%

“…However, MEA guidelines in Japan state that the treatment is not suitable for endometrial malignancy ( 4 ), and there have been no reports that have evaluated the effectiveness of MEA for the treatment of endometrial carcinoma. To the best of our knowledge, there is only a single previous report of MEA being used to treat abnormal uterine bleeding caused by endometrial carcinoma ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of microwave ablation for the treatment of endometrial carcinoma: A report of 3 cases

et al. 2016

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Microwave endometrial ablation (MEA) is effective for the emergency control of uterine hemorrhage. However, to the best of our knowledge, there has been only a single report of life-threatening hemorrhage induced by endometrial carcinoma that was treated with MEA. The present report evaluates the efficacy of MEA as an emergency therapeutic option for the control of bleeding due to advanced endometrial carcinoma and minimally-invasive, early-stage endometrial carcinoma in 3 patients. MEA was able to effectively control massive uterine bleeding due to endometrial carcinoma in 2 patients with advanced disease and was curative in a patient with minimally-invasive endometrial carcinoma. Given its safety, simplicity and effectiveness, MEA may be utilized for the emergency treatment of uterine bleeding in advanced endometrial carcinoma, and may be used as a curative treatment in early-stage endometrial carcinoma.

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“…Cerebrolysin prevents the forming of free-radicals, increases neurons viability and prevents neuronal cell death in cerebral hypoxia-ischemia. It improves memory through supporting the functions of the hippocampus which is the part of the brain where memories are stored (Sharp 2002 andKeilhoff et al, 2014).…”

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confidence: 99%

The Potential Antidepressant Effect of Adenosine Triphosphate and Cerebrolysin on Reserpine Induced Depression in Male Rats.

MMoghazy¹,

AbdElMoneimSaad²,

AHaridy³

2019

IJAR

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Background: Depression is a heterogeneous disorder that affects a person's mood, physical health and behavior. The present study aimed to investigate the potential antidepressant effect of adenosine triphosphate and cerebrolysin on reserpine induced depression in male rats through their effects on the levels of monoamine neurotransmitters and behavioral changes induced by reserpine. Material and methods: This study was conducted on 50 adult male rats divided into five groups: the first is the control group (C); the second depressed group received reserpine only. The third, fourth and fifth groups included depressed rats treated orally with citalopram as classical drug, ATP and cerebrolysin, respectively. Behavioral test, forced swim test, as well as brain neurotransmitters levels such as (MDA, 8OHdG, 5HT, DA, DOPAC, HVA, ATP and Na + -K + ATPase) measured in brain tissue. Some biochemical parameters such as ALT, AST, TSH, T 4 and testosterone were carried out in the serum. Results: Data showed that reserpine induced depressive-like behavior in the forced swim test. Additionally, reserpine produced a significant increase in the level of MAD, 8OHdG, DOPAC, HVA, T 4 , ALT and AST and significant decreased in 5-HT, DA, TSH, Testosterone, ATP and Na + -K + ATPase as compared with control group. In contrast, cerebrolysin and ATP improve the behavioral parameters, decrease oxidative markers and increase neuronal function, liver function, and thyroid function and enhance testosterone level after 21 days of treatment in comparing with reserpine group and nearly to control group. Conclusion: Cerebrolysin has pronounced effect than ATP, citalopram and ameliorate reserpine induced depression rats model.

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Successful microwave ablation of endometrial carcinoma

Cited by 18 publications

References 2 publications

Effects and mechanism of cerebroprotein hydrolysate on learning and memory ability in mice

Effects and mechanism of cerebroprotein hydrolysate on learning and memory ability in mice

Efficacy of microwave ablation for the treatment of endometrial carcinoma: A report of 3 cases

The Potential Antidepressant Effect of Adenosine Triphosphate and Cerebrolysin on Reserpine Induced Depression in Male Rats.

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