Successful Management of Retroperitoneal Malignant Fibrous Histiocytoma Involving Both Kidneys

Virgili, G; Stasi, Savino M. Di; Storti, L.; Orlandi, Augusto; Vespasiani, Giuseppe

doi:10.1080/003655900750016625

Cited by 5 publications

(2 citation statements)

References 3 publications

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“…Treatment for this neoplasm remains mostly surgical; however, this approach is often precluded due to the age of the patients, advance stage of the disease at presentation, and comorbidities [1, 2, 9, 25, 27, 28]. This tumor is not completely radiosensitive since relapses with wide spread metastasis have been observed after full courses of radiation, and deep soft tissue metastatic microfoci have been detected in surgical specimens after completion of radiation treatment [1, 9, 13].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Malignant Fibrous Histiocytoma Associated with Leukemoid Reaction or Leukocytosis: A Comprehensive Review

et al. 2012

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Inflammatory malignant fibrous histiocytoma (IMFH) associated with leukemoid reaction (LR)/leukocytosis is a rare entity. In this paper, we search PubMed for all known cases of IMFH associated with LR/leukocytosis in an attempt to draw conclusions about this variant's response to treatments and its pathophysiology. Medline electronic database was searched using key words such as malignant fibrous histiocytoma, leukemoid reaction, and leukocytosis. A total of 16 patients were found, twelve males (75%) and 4 female (25%), with a mean age of 62.6 years, ranging from 47 to 77. The mean survival was 770 days, ranging from 14 to 6570 days. Four patients were alive at last follow-up: 6570 days, 1095 days, 335 days, and 180 days, respectively. Of the 12 patients that expired, death occurred approximately 92 days after the onset of LR or leukocytosis, ranging from 3 to 334 days. We conclude that IMFH associated with LR/leukocytosis does not completely respond to chemoradiation. Overproduction of growth factors and cytokines by IMFH cells and their interactions with the inflammatory infiltrate seem to promote immunological effector cell's dysfunction and substantiate the development and growth of this neoplasm. A clear understanding of these molecular pathways is crucial in order to identify targets for potential therapy.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Malignant Fibrous Histiocytoma Associated with Leukemoid Reaction or Leukocytosis: A Comprehensive Review

et al. 2012

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“…[1] The mainstay of treatment is surgery, and adjuvant chemotherapy has also been suggested to improve survival. [3] MFHs arising from the renal parenchyma or renal capsule represent less than 6% of renal sarcomas. [4][5][6][7][8][9][10][11] The most frequent presenting symptoms are a palpable abdominal mass, fever, fatigue, weight loss, and gastrointestinal problems.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant fibrous histiocytoma of the kidney: report of a case and literature review

Göğüş

Gökçe

Süer

et al. 2014

Turkish Journal of Urology

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Primary Malignant Fibrous Histiocytoma of the Small Intestine Presenting as an Intussusception: Report of a Case

Kotan¹,

Kosem²,

Alıcı³

et al. 2002

Surgery Today

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Malignant fibrous histiocytoma occurs most commonly in the extremities and trunk, but rarely in the visceral organs. Malignant fibrous histiocytoma of the small intestine is an extremely rare condition. To our knowledge, only ten cases of primary tumors involving the small intestine have been described up to now. Among them only one case has been reported to lead to intussusception. This case report documents the appearance of a storiform-pleomorphic type primary malignant fibrous histiocytoma of the ileum, which led to intussusception, in a 58-year-old man with a 3-month history of dyspepsia, weight loss, general fatigue, and nonspecific abdominal pain. The patient was well with no sign of disease at 8 months after surgery. The clinical and pathologic characteristics of malignant fibrous histiocytoma of the small intestine as found in the literature are also reviewed.

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Successful Management of Retroperitoneal Malignant Fibrous Histiocytoma Involving Both Kidneys

Cited by 5 publications

References 3 publications

Inflammatory Malignant Fibrous Histiocytoma Associated with Leukemoid Reaction or Leukocytosis: A Comprehensive Review

Inflammatory Malignant Fibrous Histiocytoma Associated with Leukemoid Reaction or Leukocytosis: A Comprehensive Review

Primary malignant fibrous histiocytoma of the kidney: report of a case and literature review

Primary Malignant Fibrous Histiocytoma of the Small Intestine Presenting as an Intussusception: Report of a Case

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