Successful management of recurrent Acanthamoeba keratitis using topical and systemic miltefosine

Barisani-Asenbauer, Talin; Walochnik, Julia; Mejdoubi, Lamiss; Binder, Susanne

doi:10.1111/j.1755-3768.2012.f095.x

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Недавнее исследование продемонстрировало, что особенно гексадецилфосфохолин (мильтефозин) является очень эффективным также против различных штаммов акантамебы. Это вещество было недавно успешно применено в сочетании с ПГМБГ для лечения AK в Австрии [17,47,48].…”

Section: поиск новых препаратов против акunclassified

Treatment of Acanthamoeba keratitis

Marchenko

Kasparova

2016

Vestn. oftal'mol.

View full text Add to dashboard Cite

In recent years, Acanthamoeba keratitis (AK) has became a clinically significant problem because of the broad use of contact lenses that are the major risk factor of the disease. The treatment presents considerable difficulties due to similarity of clinical manifestations of AK to other keratites (bacterial, herpetic, and fungal). This often leads to late diagnosis and formation of drug-resistant cysts. There is currently no specific drug universally suitable for monotherapy of AK. Instead, 2 agents (usually chlorhexidine and poligexametilen biguanide) are used that, if combined, are effective against both trophozoites and cysts. If necessary (severe keratitis, insufficient treatment effect), diamidines (propamidine and its analogs), antifungals (fluconazole, itrakonazol), certain antibiotics (Neomycinum), and iodine-containing medications (povidone-iodine) can be prescribed. The use of corticosteroids is considered unjustified because of the risk of rapid progression (due to disturbance of local immunity and also provocation of excystation of the amoebas). The penetrative keratoplasty may be required, especially if a descemetocele or corneal perforation occurs, however, its results are generally worse than those in other keratites because of a higher risk of complications (iridocyclitis, secondary glaucoma, AK recurrence in the graft). In some cases, good results are achieved with minimally invasive surgeries, such as mechanical epithelial debridement, conjunctivoplasty and cryopreserved amniotic membrane transplantation, excimer laser phototherapeutic keratectomy, and cross-linking. In the future, gene therapy and specific chemotherapy of AK may well be developed.

show abstract

Section: поиск новых препаратов против акunclassified

Treatment of Acanthamoeba keratitis

Marchenko

Kasparova

2016

Vestn. oftal'mol.

View full text Add to dashboard Cite

show abstract

RETRACTED ARTICLE: Antiamoebic activity of synthetic tetrazoles against Acanthamoeba castellanii belonging to T4 genotype and effects of conjugation with silver nanoparticles

Ali

Fatima

et al. 2020

Parasitol Res

View full text Add to dashboard Cite

An update onAcanthamoebakeratitis: diagnosis, pathogenesis and treatment

2015

View full text Add to dashboard Cite

Free-living amoebae of the genus Acanthamoeba are causal agents of a severe sight-threatening infection of the cornea known as Acanthamoeba keratitis. Moreover, the number of reported cases worldwide is increasing year after year, mostly in contact lens wearers, although cases have also been reported in non-contact lens wearers. Interestingly, Acanthamoeba keratitis has remained significant, despite our advances in antimicrobial chemotherapy and supportive care. In part, this is due to an incomplete understanding of the pathogenesis and pathophysiology of the disease, diagnostic delays and problems associated with chemotherapeutic interventions. In view of the devastating nature of this disease, here we present our current understanding of Acanthamoeba keratitis and molecular mechanisms associated with the disease, as well as virulence traits of Acanthamoeba that may be potential targets for improved diagnosis, therapeutic interventions and/or for the development of preventative measures. Novel molecular approaches such as proteomics, RNAi and a consensus in the diagnostic approaches for a suspected case of Acanthamoeba keratitis are proposed and reviewed based on data which have been compiled after years of working on this amoebic organism using many different techniques and listening to many experts in this field at conferences, workshops and international meetings. Altogether, this review may serve as the milestone for developing an effective solution for the prevention, control and treatment of Acanthamoeba infections.

show abstract

Successful management of recurrent Acanthamoeba keratitis using topical and systemic miltefosine

Cited by 3 publications

References 0 publications

Treatment of Acanthamoeba keratitis

Treatment of Acanthamoeba keratitis

RETRACTED ARTICLE: Antiamoebic activity of synthetic tetrazoles against Acanthamoeba castellanii belonging to T4 genotype and effects of conjugation with silver nanoparticles

An update onAcanthamoebakeratitis: diagnosis, pathogenesis and treatment

Contact Info

Product

Resources

About