Successful management of pregnancy and hemolytic disease of the newborn due to anti‐Hr_O in a woman of the D‐ ‐ phenotype

Transfusions of least‐incompatible blood with intravenous immunoglobulin plus steroids cover in two patients with rare antibody

“…This was based on the recommendation made by the National Institute for Health and Care Excellence (NICE) UK . In addition to that, there were two reports of severe HDN implicating the rare anti‐Rh17, and in both cases, as D− blood was unavailable, least‐incompatible units were selected for exchange transfusion and transfused with IVIG cover with a good outcome . Furthermore, IVIG has also been prescribed in conjunction with transfusion of random platelet (PLT) units in neonatal alloimmune thrombocytopenia when HPA‐compatible PLTs are not readily available …”

Fetal Hemolytic Disease due to Anti-Rh17 Alloimmunization

“…In Western populations, -D-/-D-is an extremely rare Rh phenotype, with only 3 cases of hemolytic disease of the fetus and newborn in sensitized -D-/-D-women reported in the English language literature [2][3][4]. On the other hand, the frequency of the -D-/-D-phenotype among Japanese is much higher (approximately 1 in 100,000) and 50 cases of hemolytic disease of the fetus and newborn in -D-/-D-women have been reported in Japan.…”

“…A second intrauterine transfusion at 32 5/7 weeks of gestation was avoided, because access to the umbilical cord site was restricted at the free portion. Only one previous study in English reported successful management with an intrauterine transfusion for fetal hemolytic anemia in a sensitized -D-/-D-woman, though cordocentesis at 33 weeks of gestation was avoided in that patient because of fetal activity and an unfavorable position [3].…”

“…Three cases were found in English language reports and 50 cases in Japanese literature, of which prenatal diagnosis was made in 2 and 5, respectively [3,4,[7][8][9][10][11]. Those 7 cases and the present one are summarized in table 1.…”

Successful transfusion care for a patient with the Rhesus -D- phenotype and antibodies against Rh17 and two additional alloantibodies

“…To date the clinical relevance of the -D- phenotype has been predominantly described in pregnant women, causing mild to fatal hemolytic disease of the newborn [4, 7–10]. We describe the successful treatment of a patient with recurrent need of transfusions despite the presence of antibodies against the high-prevalence antigens of the RhCcEe polypeptide combined with anti-Jk a .…”