Successful management of mild atopic dermatitis in adults with probiotics and emollients

Abstract

<jats:title>Abstract</jats:title><jats:p>Atopic dermatitis is characterized by impaired skin and mucous membrane barrier function. Measures improving barrier integrity decrease the influence of environmental factors that might exacerbate inflammation. Ten adult patients with mild-to-moderate atopic dermatitis consumed for three months fermented with potent antioxidative probiotic, L. fermentum ME-3 (DSM 14241) goat milk 200 mg/day. A control group consisted of six patients, not supplemented by probiotic. All patients used emollients regularly. Skin iron levels, glutathione redox ratios (GSSG/GSH), diene conjugate (DC) amounts, blood glutathione status, oxidized low-density lipoprotein (oxLDL), and total antioxidativity was measured at the baseline and after three months. A significant decrease in skin iron levels, DC amounts, and glutathione redox ratio occurred in the probiotic-supplemented group compared to the control group (P &lt; 0.05 for all indices). In the same group, blood levels of oxLDL decreased (p &lt; 0.05), and GSH levels increased (P &lt; 0.001) with concomitant improvement in the GSSG/GSH ratio. Blood antioxidativity markers also showed an improvement. The results of our study demonstrate that regular use of probiotics with antioxidative properties coupled with the use of lipid-containing emollients considerably decreases inflammation and concomitant oxidative stress in adult patients with mild-to-moderate atopic dermatitis. This effect was observed both in the skin and in the blood.</jats:p>

An antioxidant probiotic reduces postprandial lipemia and oxidative stress

“…Recent data suggest that an increased production of atherogenic and inflammatory oxLDL within the vessel wall suppresses several immunity-related cells, including regulatory T cells [27] which normally exert antiatherogenic and anti allergic effects. It should be noted that previous trials have shown the positive effect of ME-3 on blood LDL, prolonging its resistance to oxidation, lowering the content of oxLDL and BDC-LDL and enhancing the total antioxidative capacity of the blood [1,11,14]. The systemic influence of LfME-3 on the host´s OxS-load is seen in the decline of the values of isoprostanes, which are accepted as an informative marker for the body's systemic OxS-burden [28].…”

“…It is of human origin [9] and a safety-proven probiotic exhibiting both antimicrobial and antioxidative benefits under different in vitro and in vivo conditions [10][11][12] and having a history of safe use in foodstuffs, especially in kefir, in Finland and the Baltic countries. Encouraged by the results of our previous trials with LfME-3 [1,2,10,11,[13][14][15][16] we aimed to carry out a study to evaluate the effects of kefir enriched with probiotic L. fermentum ME-3 on postprandial oxidative stress, postprandial lipemic response and blood lipoprotein status when added to an ordinary diet.…”

Proteomic proof that a probiotic elevates glutathione level in human serum

“…A food containing an antioxidant LAB strain that has been proven to contain glutathione and has the ability to synthesize and handle glutathione [10] has shown clinically relevant positive effects in humans [4,18]. Now we are able to prove with MALDI-TOF mass spectrometry analysis that the concentration of glutathione in the Figure 3.…”

Probiotics and Oxidative Stress

“…There is also support from RCTs for the efficacy of a probiotic mix in patients with inflammatory bowel disease (Kajander et al, 2007;Hovyeda et al, 2009). Nevertheless the evidence to date suggests that the major clinical effects of probiotics are seen in prevention GI disorders, probiotic therapy has also been explored in non-GI diseases, including the treatment of atopic eczema in children and adults (Kalliomaki et al, 2001(Kalliomaki et al, , 2007Kaur et al, 2008). A specialprobiotic, LfME-3, offers a good potential also in cardiovascular health management.…”