Successful Management of Metastatic Eccrine Porocarcinoma

Abstract

Eccrine porocarcinoma (EPC) is a rare tumor. It develops from the intraepidermal ductal portion of the eccrine sweat gland. Metastatic disease is rare. We report a new case of metastatic eccrine porocarcinoma with a successful management and a good response to docetaxel. A 54-year-old man was admitted with a mass in the breast. Biopsy specimen found carcinomatous tumor proliferation with large anastomosing ducts. Cellular atypia were noted, with eosinophilic cytoplasm and round to oval nuclei. The tumor showed positive immunoreactivity for ACE and negative to anti-PS-100. Resection was performed. One year later, he presented with local and metastatic recurrences. The patient had received 3 cycles of cisplatin and 5-fluorouracil; he progressed with increase in mass size and number of lung lesions. He has been undergoing three cycles of docetaxel with complete response in the lung and regression of the breast mass. The mass was excised. Porocarcinoma is a very rare entity and poorly understood. In the metastatic phase, it has modest or no sensitivity to anticancer treatment. Docetaxel should be considered in the metastatic eccrine porocarcinoma.

Porocarcinoma: reporte de caso y revisión de la literatura

“…Pese a que la pertinencia de la radioterapia no está bien definida, se ha reportado control de la enfermedad mediante radioterapia superficial más hipertermia. Dentro del tratamiento sistémico se han utilizado múltiples fármacos, como el metotrexato, el cisplatino, la doxorubicina y la bleomicina con resultados poco alentadores 10 ; no obstante, hay informes de casos aislados en los que se ha administrado docetaxel como tratamiento sistémico y ha dado buenos resultados.…”

Eccrine Porocarcinoma with Zosteriform Metastasis

“…Different therapeutic regimens have been proposed with variable results and based on 50% of cases in platinum, with global survivals of three to 35 months [12,15]. Docetaxel, as a single agent, has been used in metastatic eccrine porocarcinoma with symptomatic and radiological response lasting for several months and with good tolerance [19,20]. Taxane and carboplatin regimen concomitant with radiotherapy was used in our case.…”

Porocarcinoma ecrino metastásico

“…En un caso de porocarcinoma ecrino localizado en mama, se indicó una resección quirúrgica con intensión curativa; un año después se presentó enfermedad recurrente local con metástasis a pulmón, con tratamiento de 3 ciclos de cisplatino y 5 ciclos de fluorouracilo sin mejoría clínica. Posterior a ello se indicó 3 ciclos de docetaxel con respuesta completa en el pulmón y regresión de la masa mamaria (16) . De igual manera, un reporte caso observó una lesión exofítica, pigmentada, inmóvil en cuero cabelludo, con diagnóstico de porocarcinoma ecrino, tratado quirúrgicamente; posteriormente se presentó erupción cutánea y placas eritematosas en región cervical derecha, hombro, y tórax, con estudio histopatológico de porocarcinoma ecrino metastásico, por lo que recibió tratamiento con quimioterapia (17) .…”