2008
DOI: 10.1016/j.healun.2008.03.019
|View full text |Cite
|
Sign up to set email alerts
|

Successful Management of Immunosuppression in a Patient With Severe Hyperammonemia After Lung Transplantation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
32
0

Year Published

2010
2010
2023
2023

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 34 publications
(33 citation statements)
references
References 9 publications
(17 reference statements)
1
32
0
Order By: Relevance
“…It was previously speculated to result from an inborn error of urea metabolism, unmasked by calcineurin inhibition (3,4). We recently demonstrated a strong association between Ureaplasma infection and hyperammonemia syndrome and reported that antimicrobial therapy targeting this organism reverses the clinical syndrome (5).…”
Section: To the Editormentioning
confidence: 97%
See 1 more Smart Citation
“…It was previously speculated to result from an inborn error of urea metabolism, unmasked by calcineurin inhibition (3,4). We recently demonstrated a strong association between Ureaplasma infection and hyperammonemia syndrome and reported that antimicrobial therapy targeting this organism reverses the clinical syndrome (5).…”
Section: To the Editormentioning
confidence: 97%
“…It is well established that children with SCD have progressive changes in pulmonary function testing (PFT), with decreased lung volumes and flows (3). Airflow limitation and airway hyperresponsiveness are associated with increased morbidity and premature death (4,5). Hydroxyurea (HU) is now widely recommended for the treatment of individuals with SCD of the SS and S/b 0 genotypes and should be offered to children regardless of clinical severity of SCD (3).…”
Section: Effect Of Hydroxyurea Therapy On Pulmonary Function In Childmentioning
confidence: 99%
“…However, there have been no reports on chemotherapy agents (taxanes and platinum agents) used in the treatment of ovarian cancer, as the case in our patient. Surgical procedures or interventions reported to be associated with hyperammonemia include lung transplantation [10], bone marrow transplantation [11], and bariatric surgery [12]. Although the most common cause of hyperammonemia seems to be hepatic dysfunction, this is unlikely to be the cause in our patient given the normal liver function test results.…”
Section: Discussionmentioning
confidence: 92%
“…[1][2][3][4][5][6] When it did occur in our patient it was in the form of surges lasting minutes, making it unlikely that ICP management other than the aggressive treatment of the hyperammonemia would have had any additional benefit.…”
Section: 2mentioning
confidence: 83%