Successful management of cerebral venous sinus thrombosis due to adenomyosis: Case reports and literature review

CA125-Associated Activated Partial Thromboplastin Time and Thrombin Time Decrease in Patients with Adenomyosis

“…12,40 A recent study also found that adenomyosis can result in cerebral venous sinus thrombosis and found a high CA125 level in these patients. 41 And the same results were observed in our study. Our study also found a higher CA125 level in adenomyosis than that in the uterine leiomyoma and the CIN-III patients.…”

Isolated distal deep vein thrombosis associated with adenomyosis: Case report and literature review

“… 26 Limited data are available regarding other types of thrombotic events. To further investigate this association, we conducted a literature search on PubMed using the terms “adenomyosis AND thrombo OR infarction.” This search strategy yielded a total of 22 eligible case or series reports (Table 1 ), including 25 cases (75.7%) of ischemic stroke, 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 6 cases (18.2%) of PE, 22 , 23 and 2 cases (6.1%) of DVT. 24 , 25 The median age of these documented patients was 45 years (range 34–59), with a tendency to experience thrombotic events during menstrual cycles.…”

“…The association between CA125 levels and the severity of adenomyosis remains uncertain. Nonetheless, a pooled analysis of 23 documented stroke cases 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 with CA125 measurements revealed a significant increase in CA125 levels among nine individuals (cases 1, 2, 5, 10, 17–19, 21, 24) experiencing systemic embolism (defined as stroke complicating extremity or organ embolism) and/or recurrent embolism, in contrast to the 14 cases (cases 4, 6–9, 11–16, 20, 23, 25) with isolated and nonrecurrent embolism (see Figure 3 ). This preliminary investigation emphasizes the need for further research to establish the potential value of CA125 in the treatment and monitoring of thrombotic complications associated with adenomyosis.…”

“… 2 In 1991, Kupryjańczyk described a case of intravascular endometriosis with thrombosis in a patient diagnosed with adenomyosis. 3 Subsequently, several isolated case reports and case series have documented the occurrence of ischemic stroke 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 and pulmonary embolism (PE) 22 , 23 in patients with adenomyosis, suggesting a possible association with hypercoagulability induced by this disorder. However, there are few reports of cases complicated by isolated deep vein thrombosis (DVT).…”