Successful management of an infant with a giant hemangioma of the retroperitoneum and Kasabach-Merritt Syndrome with α-interferon

Benign Cutaneous Vascular Tumors of Infancy

“…94,95 Interferon alfa is useful for treating both the tumor and associated KMS, and is effective in about 50% of children. [96][97][98] Multimodal intervention has also been successful using embolization, interferon, cyclophosphamide, ⑀-aminocaproic acid, and compression therapy. 99 Isolated cases of improvement with vincristine therapy, either alone or in combination with other chemotherapeutic agents, have also been reported.…”

Retroperitoneal hemangioma of infancy

“…They are most often incidentally found as a 5 cm or greater asymptomatic mass [20,21]. A variant of hemangiomas known as Kaposiform hemangioendotheliomas have been reported to occur within the pediatric population in the retroperitoneal space [22][23][24][25][26]. Although these have angiomatous areas of capillary proliferation, they are histologically distinguished from infantile capillary hemangiomas by the presence of Kaposiform areas with fascicles or nodules of spindled cells surrounding slitlike spaces.…”

Endovascular Treatment of Huge Cervicofacial Hemangioma Complicated by Kasabach-Merritt Syndrome

“…There are several therapeutic options in the treatment of hemangioma with Kasabach-Merritt syndrome, which include platelet transfusion, corticosteroids, cryoprecipitate, heparin, ε-aminocaproic acid, dipyridamole, aspirin, cyclophosphamide, interferon, irradiation, local compression, surgical resection, laser therapy, cryosurgery and embolization [1, 2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17]. The purposes of the treatment are to control coagulopathy and to eradicate or reduce the size of the lesions.…”