Successful Management of Acute Liver Failure Patients Waiting for Liver Transplantation by On-Line Hemodiafiltration with an Arteriovenous Fistula

Abstract

On-line hemodiafiltration (OLHDF) is one of the treatment options in the management of acute liver failure (ALF) in Japan. It is essential to avoid infection in the management of ALF. In fact, infection is one of the prognostic factors in ALF. In this report, we present a middle-aged Japanese man with ALF associated with benzbromarone use. He was successfully managed without infection until liver transplantation by creating an arteriovenous fistula for OLHDF. Utilizing an arteriovenous fistula for OLHDF, rather than inserting a vascular access catheter, is a beneficial option to avoid infectious diseases in the management of ALF.

A Case of Recent Liver Injury Induced by Benzbromarone

“…In only one of these nine cases, the course of benzbromarone was more than 6 months [15]. Of note, even though more than 6 months had passed since the commencement of benzbromarone, it is possible that benzbromarone could induce liver injury, including ALF [9].…”

“…There have been several reports that hepatotoxicity is associated with benzbromarone [5][6][7][8][9][10][11]. Acute liver injuries including acute liver failure (ALF) have occasionally been observed in patients treated with benzbromarone [5][6][7][8][9]11].…”

“…There have been several reports that hepatotoxicity is associated with benzbromarone [5][6][7][8][9][10][11]. Acute liver injuries including acute liver failure (ALF) have occasionally been observed in patients treated with benzbromarone [5][6][7][8][9]11]. Benzbromarone and benzarone are used for the treatment of peripheral venous disorders in Europe, and they induce drug-induced autoimmune hepatitis and chronic active hepatitis, respectively [10,12].…”

Successful retreatment with grazoprevir and elbasvir for patients infected with hepatitis C virus genotype 1b, who discontinued prior treatment with NS5A inhibitor-including regimens due to adverse events

“…He did not drink alcohol and had no family history of HCV infection. He had a medical history of drug-induced liver injury of benzbromarone [ 18 – 20 ] and received a transfusion for renal anemia 9 years ago.…”