Successful long-term effects of direct renin inhibitor aliskiren in a patient with atherosclerotic renovascular hypertension

Morisawa, Norihiko; Sugano, Naoki; Yamakawa, Takafumi; Kuriyama, Satoru; Yokoo, Takashi

doi:10.1007/s13730-016-0246-x

Cited by 3 publications

(1 citation statement)

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“…Renin Angiotensin Aldosterone System Functions in Renovascular Hypertension DOI: http://dx.doi.org/10.5772/intechopen.97491 but need close examining for kidney failure and hyperkalemia [4]. Aliskiren, a direct renin inhibitor, may still be a potential option for the treatment of high blood pressure in some forms of hypertension such as chronic kidney disease (CKD) and renovascular hypertension [44]. In a clinical study, aliskiren combined with olmesartan reduced proteinuria by about 40% from baseline in patients with CKD with persistent proteinuria [45].…”

Section: Renin Angiotensin Aldosterone System Function In Renal Artery Stenosismentioning

confidence: 99%

Renin Angiotensin Aldosterone System Functions in Renovascular Hypertension

Gómez¹

2021

Renin-Angiotensin Aldosterone System

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The renin angiotensin aldosterone system (RAAS) plays a key function in renovascular hypertension induced by renal artery stenosis (RAS). RAS causes a decrease in renal perfusion in the stenosed kidney which in turn stimulates renin the rate limiting enzyme in RAAS. This stimulation triggers a series of events starting with renin release leading to Ang II production, decrease in sodium excretion, increase sympathetic tone; all contributing to the development of renovascular hypertension. In RAS increase of superoxide reduce nitric oxide in the afferent arteriole increasing vasoconstriction and a marked decrease in glomerular filtration rate. In renovascular hypertension prostaglandins mediate renin release in the stenosed kidney. Targeting different RAAS components is part of the therapy for renovascular hypertension, with other options including renal nerves denervation and revascularization. Different clinical studies had explored revascularization, RAAS blocking and renal nerves denervation as a therapy. We will discuss organ, cellular and molecular components of this disease.

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Section: Renin Angiotensin Aldosterone System Function In Renal Artery Stenosismentioning

confidence: 99%