Successful improved peripheral tissue perfusion was seen in patients with atherosclerosis after 12 months of treatment with aged garlic extract

Abstract

Patients with arteriolosclerosis have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract has shown to have a positive impact on vascular elasticity. The present study aimed to assess the effect of long‐term treatment with AGE on peripheral tissue perfusion in patients with confirmed atherosclerosis. Ninety three patients with a CT‐scan confirmed coronary artery arteriolosclerosis were randomised in a double‐blind manner to placebo or 2400 mg AGE daily for 1 year. Peripheral tissue perfusion was evaluated at 0‐ and 12‐months using Laser Speckle Contrast Imaging. Measurement of post occlusive reactive hyperemia (PORH) and cutaneous vascular conductance (CVC) using acetylcholine iontophoresis (Ach) was conducted. After 12 months a significant increase of 21.6% (95% CI 3.2%‐40.0%, P < .05) was seen in the relative change of PORH in the AGE compared with the placebo group. The same response was seen for CVC and Ach with an increase of 21.4% (95% CI 3.4%‐39.4%, P < .05) in the AGE group compared with the placebo group. Aged garlic extract regenerated peripheral tissue perfusion and increase microcirculation in patients with arteriolosclerosis. Adequate peripheral tissue perfusion and tissue oxygen tension are important prerequisites for successful tissue repair. Restored microcirculation in patients could hypothetically facilitate wound healing.

Effect of Encapsulated Purple Garlic Oil on Microvascular Function and the Components of Metabolic Syndrome: A Randomized Placebo-Controlled Study—The ENDOTALLIUM Study

“…Recently, the CORDIOPREV study [ 35 ], a randomized, double-blind, controlled trial, showed that long-term dietary intervention with either the Mediterranean diet or a low-fat diet significantly improved skin microvascular endothelial function in over 1000 coronary patients. Regarding garlic-derived products, Lindstedt et al [ 38 ] reported a significant increase of 21.6% in the relative change of PORH in patients with atherosclerosis consuming aged garlic extract for 12 months. This result is in line with our findings, as we observed an increase of 18.8% in PORH in the purple garlic oil group, even after a shorter intervention period.…”

Evaluation of the Influence of Short Tourniquet Ischemia on Tissue Oxygen Saturation and Skin Temperature Using Two Portable Imaging Modalities

“…The lower values of skin temperature and tissue oxygen saturation at two timepoints in the healthy participant group might be explained as increasing age is an independent risk factor for the development of atherosclerosis [ 35 ] and due to that impairs microcirculation [ 36 ].…”

Heart–brain interaction in cardiogenic dementia: pathophysiology and therapeutic potential

“…Modern pharmacological studies have shown that aged garlic extract (AGE) reduces the risk of heart disease and dementia because of its multiple pharmacological effects including antioxidative stress, anti-inflammation, and lipid metabolism regulation ( 111 ). A clinical study of 93 arteriosclerosis patients aged 40–75 years found that AGE may effectively increase peripheral tissue perfusion and microcirculation by increasing NO release and improving endothelial function after 12 months of treatment ( 112 ). Moreover, after administration to mice, AGE increased NO production by 30%–40% via activation of constitutive NO synthase (cNOS), which was conducive to further vasodilation ( 113 ).…”