Successful homotransplantation of the human kidney between identical twins

Merrill, John P.; Murray, Joseph E.; Harrison, J. Hartwell; Guild, Warren R.; Barry, John M.

doi:10.1016/s0022-5347(02)80268-3

Cited by 78 publications

(87 citation statements)

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“…The first live donor nephrectomy was performed in 1954 via an open flank approach for the seminal identical twin transplant, and made clinical solid organ transplantation a reality (1). At that time donor safety was the overriding concern.…”

Section: Introductionmentioning

confidence: 99%

Concomitant Surgery With Laparoscopic Live Donor Nephrectomy

Molmenti

Pinto

Montgomery

et al. 2003

American Journal of Transplantation

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Routine live donor evaluations reveal unexpected silent pathologies. Herein, we describe our experience treating such pathologies at the time of laparoscopic donor nephrectomy. We have not encountered any previous reports of such an approach. We prospectively collected data on 321 donors. Concomitant surgeries at the time of procurement included two laparoscopic adrenalectomies, one colposuspension, one laparoscopic cholecystectomy, and one liver biopsy. Mean operative time was 321 min (range 230-380), with a mean blood loss of 280 mL (range 150-500). No blood transfusions were required. The left kidney was procured in four cases. The right kidney was obtained on one occasion. Mean hospital stay was 3 days (median 3, range 2-4). No short-or longterm complications have been identified. Mean follow-up time was 2.63 years (median 2.76, range 2.23-2.99). Four of the five kidney recipients were firsttime transplants who had not yet started dialysis. Simultaneous surgical interventions at the time of laparoscopic live kidney donation are safe and can be undertaken in selected cases. This practice is beneficial to both the donor and the recipient, and is likely to become more commonplace with changing practice patterns involving donor evaluation and management.

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Section: Introductionmentioning

confidence: 99%

Concomitant Surgery With Laparoscopic Live Donor Nephrectomy

Molmenti

Pinto

Montgomery

et al. 2003

American Journal of Transplantation

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“…The kidney transplant procedure originally developed by Kuss and the other French surgeons was used for this patient. It has been performed hundreds of thousands of times since then, including for the celebrated identical (monozygotic) twin transplantations performed by Murray (Nobel Laureate, 1990) et al 17 in Boston.…”

Section: Homotransplantation (Allotransplantation)mentioning

confidence: 99%

“…usually litter mates. Efforts by Hume et al: 17 Rapaport et al: lt ; and others to broaden the acceptable histocompatibility requirements were totally unsuccessfulleading to lethal GVHD. rejection.…”

Section: With Recipient Irradiationmentioning

confidence: 99%

“…17.21 As in the earlier mother-to-son transplant in France, 16 no effort was made to preserve the transplanted kidney, which functioned promptly even though it underwent 82 minutes of warm ischemia time. According to Merrill et al,17 the bold step of exploiting the principle of genetic identity for wholeorgan transplantation had been suggested by the recipient's phYSician, David C. Miller, of the Public Health Service Hospital. Boston.…”

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confidence: 99%

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History of Clinical Transplantation

Starzl¹

2008

Surgery

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“…When a kidney is transplanted from a non-identical individual, the allograft; the recipient mounts an immune response termed as an alloimmune response [1]. The alloimmune response is initiated by the T cell recognition of the alloantigen and process is commonly known as the allorecognition.…”

Section: Introductionmentioning

confidence: 99%

Immunology for Renal Transplantation: A Review

Shrestha¹

2013

J Transplant Technol Res

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The current success of renal transplantation (RT) is the result of advancement in the understanding of the transplant immunology from gross allograft rejection to cellular and antibody response to the current molecular level. Laboratory assay technologies have been developed to characterise patient sensitisation and to detect pre-existing donor-specific antibodies (DSA) in pre-transplant crossmatch, which has helped prevent premature transplant losses from early and late antibody-mediated rejection. After a RT, pre-existing or de novo DSA are routinely monitored for modulation of immunosuppressive regimens. Therefore, it is mandatory for the personnel involved in the management of RT recipients to have clear understanding of the components of transplantation immunology and be familiar with the modern immunological techniques used in RT.

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Successful homotransplantation of the human kidney between identical twins

Cited by 78 publications

References 0 publications

Concomitant Surgery With Laparoscopic Live Donor Nephrectomy

Concomitant Surgery With Laparoscopic Live Donor Nephrectomy

History of Clinical Transplantation

Immunology for Renal Transplantation: A Review

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