Successful endoscopic mucosal resection of a solitary extramedullary plasmacytoma in the sigmoid colon

Kodani, Tomohiro; Osada, Taro; Terai, Tomohiro; Ohkusa, T.; Shibuya, Terry Y.; Sakamoto, Naoto; Beppu, Kazuko; Kato, Jun; Nagahara, Akira; Watanabe, Hirokazu; Watanabe, Shohei

doi:10.1055/s-0030-1256451

Cited by 11 publications

(7 citation statements)

References 3 publications

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“…As endoscopic techniques continue to evolve, endoscopists have been able to treat larger and more invasive extramedullary gastrointestinal plasmacytomas in more aggressive but clinically safe and effective manners. Kodani et al [ 9 , 10 ] have shown successful endoscopic techniques in resection of colonic plasmacytomas which extend into the mucosa. In our case, the plasmacytoma was pedunculated and did not appear to invade the mucosa either grossly or on the histology as shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

Discovery of a rare ileocecal plasmacytoma

Gabriel

Savu

2014

Journal of Surgical Case Reports

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Here we report the discovery of an extramedullary ileocecal plasmacytoma, a rare entity reported only ∼60 times in the literature. This finding occurred during management of a patient who had sustained an occult perforation during diagnostic colonoscopy. We explored the patient finding a large ileocecal perforation, and thus a right hemicolectomy was performed. Interestingly, the pathology of the mass was consistent with an extramedullary plasmacytoma, which is a very rare gastrointestinal diagnosis. We end by summarizing the presentation and work-up of extramedullary plasmacytoma.

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Section: Discussionmentioning

confidence: 99%

Discovery of a rare ileocecal plasmacytoma

Gabriel

Savu

2014

Journal of Surgical Case Reports

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“…46 Only 2 cases were presented with perforation, and surgery was the main modality of treatment; nevertheless, one reported case was treated with EMR. 33,34,38 In general, EMPs are considered radiosensitive, with a local control rate of 90-100%, 47,57 and radiotherapy is the preferred approach for those involving the head, neck, anal 46 and rectal 48 regions. When complete surgical resection is feasible, surgery remains the treatment of choice for colonic lesions.…”

Section: Discussionmentioning

confidence: 99%

A Durable Response of Primary Advanced Colonic Plasmacytoma Using a Combination of Surgical Resection and Adjuvant Bortezomib: A Case Report and Literature Review

Alfar¹,

Kamal²,

Razeq³

et al. 2022

OTT

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Background: Primary isolated extra-medullary plasmacytoma (EMP) is a rare entity that most commonly involves the nasopharynx or upper respiratory tract. Only 10% of cases involve the gastrointestinal tract, mainly the small intestine and the stomach. Involvement of the colon is extremely rare with less than 40 reported cases worldwide. Case Presentation: We report a case of a 57-year-old man who was presented with a 3-week history of fresh bleeding from the rectum. Colonoscopy showed a polypoidal mass arising from the ascending colon; biopsy showed clonal plasmacytosis and a primary colonic solitary EMP diagnosis was made after exclusion of multiple myeloma (MM). Accordingly, the patient underwent a right hemicolectomy, followed by 6 cycles of bortezomib, cyclophosphamide, and dexamethasone (VCD). The patient continued to be disease-free 30 months after the completion of his chemotherapy. Conclusion: To our knowledge, this is the first reported case of primary colonic plasmacytoma managed with surgical resection followed by an adjuvant bortezomib-based regimen with a durable response.

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“…However, patients with surgical margin involvement should receive adjuvant radiotherapy, whereas combined treatments are recommended if complete surgical resection of the tumor is not possible and/or the lymph node area is affected [21]. Endoscopic treatments, such as endoscopic submucosal dissection and EMR, are becoming increasingly viable treatment options for colorectal EMP [9,10,22].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Extramedullary Plasmacytoma of the Rectum with Endoscopic Mucosal Resection: A Case Report and Literature Review

Ling

Liu

et al. 2022

Preprint

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Purpose Extramedullary plasmacytoma (EMP) is an unusual plasma cell disease.We report a case of EMP arising in the rectum, which is fully removed using endoscopic mucosal resection (EMR).Methods The patient’s clinical, endoscopic, and histologic data were reviewed, as well as the past literature of rectal EMP with a focus on the clinical presentation, treatment and outcome.Results A 64-year-old woman was referred to our hospital with recurrent diarrhea for longer than half a month. She underwent colonoscopy which revealed a polypoid lesion. The lesion was fully excised using EMR, and histopathological examination coupled with immunohistochemistry of the endoscopic biopsy confirmed a primary EMP of the rectum. She did not receive radiotherapy or chemotherapy after being diagnosed with EMP and experienced no recurrence or progression during the 6-month follow-up period.Conclusion Rectal EMP is an extremely rare clinical entity, Only 13 cases have been reported in the English-language literature as far as we know. Clinical suspicion is infrequent owing to its location and nonspecific manifestations. The diagnosis of EMP requires biopsy-proven monoclonal plasma cell infiltration of a single lesion, and the exclusion of multiple myeloma. Although EMP is a highly radiosensitive tumor, endoscopic therapy is increasingly becoming a good option for colorectal EMP when complete endoscopic resection of the tumor is possible. Generally, rectal EMP has an indolent course and the prognosis is favorable, but occasionally it may progress to multiple myeloma, or relapse. Therefore, the patients of EMP should be followed-up for a long time.

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Successful endoscopic mucosal resection of a solitary extramedullary plasmacytoma in the sigmoid colon

Cited by 11 publications

References 3 publications

Discovery of a rare ileocecal plasmacytoma

Discovery of a rare ileocecal plasmacytoma

A Durable Response of Primary Advanced Colonic Plasmacytoma Using a Combination of Surgical Resection and Adjuvant Bortezomib: A Case Report and Literature Review

Treatment of Extramedullary Plasmacytoma of the Rectum with Endoscopic Mucosal Resection: A Case Report and Literature Review

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