Successful desensitization with chemotherapeutic drugs: a tertiary care center experience

Abstract

This study has been presented as a oral presentation at the XXVI. National Allergy and Clinical Immunology Congress between 9-13 November 2019 and presented as a poster EAACI Digital Congress 06 -08 June 2020.

Successful nedaplatin desensitization therapy in a patient with platinum-sensitive recurrent ovarian cancer: A case report and literature review

“…Clinicians often encounter HSR, which causes life-threatening conditions, to platinum-based agents in patients with ovarian cancer ( Çakmak et al, 2021 ). The incidence of HSRs increases following an increase in the frequency of administration of platinum-based agents ( Rose et al, 2003 ).…”

“…Hypersensitivity reaction (HSR) is a serious adverse reaction of anticancer drugs with anaphylactic features ( Çakmak et al, 2021 ). Although platinum-based agents play a crucial role in the treatment of ovarian cancer, the incidence of HSR increases following an increased frequency of administration of platinum-based agents ( Bartoletti et al, 2020 , Rose et al, 2003 ).…”

“…The occurrence of HSR forces patients to discontinue their treatments in some cases. Desensitization is a well-known strategy against HSR with a high success rate ( Cakmak et al, 2021 , Castells et al, 2008 , Hesterberg et al, 2009 ). However, patients who have had a history of HSR to one platinum agent often develop HSR to another ( Michikami et al, 2013 ).…”

“…Nedaplatin, a platinum-based agents, is approved in several countries, and its efficacy and safety in patients with ovarian cancer has been reported ( Michikami et al, 2013 ). Previous reports have demonstrated the efficacy of desensitization therapy with carboplatin, cisplatin, and oxaliplatin ( Cakmak et al, 2021 , Takase et al, 2015 ). However, to the best of our knowledge, nedaplatin desensitization therapy for patients with PSR ovarian cancer has never been reported.…”

Allergy testing for Cremophor in a patient with cervical cancer with infusion reactions to paclitaxel and docetaxel

“…However, more immunological studies are needed to elaborate on this 19–21. Further, several studies have shown that docetaxel desensitisation protocols can be performed safely, and desensitisation therapy should be the treatment of choice if treatment with docetaxel is necessary for allergic patients 22–24…”