Successful control of norovirus outbreak in a pediatric ward with multi-bed rooms

Han, Mi Seon; Chung, Seung Min; Kim, Eun Jin; Lee, Chan Jae; Yun, Ki Wook; Choe, Pyoeng Gyun; Kim, Nam Joong; Choi, Eun Hwa

doi:10.1016/j.ajic.2019.07.022

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…In addition, BioFire ® GI Panel showed a higher pathogen positivity rate compared to conventional studies for these pathogens, thereby reducing the likelihood of in-hospital transmission caused by false negative results. Because norovirus and rotavirus are pathogens with high transmissibility and have been the cause of hospital outbreaks, the utility of the BioFire ® GI Panel may be more advantageous than conventional studies in infection control and in hospital transmission due to the rapid reporting time and high detection sensitivities [ 11 , 28 ]. Furthermore, with the use of the BioFire ® GI Panel in pediatric emergency units especially during outbreaks such as the Coronavirus disease-19 (COVID-19) pandemic, the fast reporting time may be able to rule out more severe pathologies of diarrhea such as multisystem inflammatory syndrome, which may be a foreseen benefit and clinical value of the BioFire ® GI Panel.…”

Section: Discussionmentioning

confidence: 99%

Quality Improvements in Management of Children with Acute Diarrhea Using a Multiplex-PCR-Based Gastrointestinal Pathogen Panel

et al. 2021

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Conventional methods for etiologic diagnoses of acute gastroenteritis (AGE) are time consuming and have low positive yield leading to limited clinical value. This study aimed to investigate quality improvements in patient management, antibiotic stewardship, and in-hospital infection transmission prevention using BioFire® FilmArray® Gastrointestinal Panel (GI Panel) in children with acute diarrhea. This was a prospective study recruiting children <19 years old with new onset diarrhea during the study period, and a matched historical cohort study of children diagnosed with AGE during the 4 years prior. Patients in the prospective cohort underwent stool testing with GI Panel and conventional methods. A total of 182 patients were included in the prospective cohort, of which 85.7% (n = 156) had community-onset and 14.3% (n = 26) had hospital-onset diarrhea. A higher pathogen positivity rate for community-onset diarrhea was observed by the GI Panel (58.3%, n = 91) compared to conventional studies (42.3%, n = 66) (p = 0.005) and historical cohort (31.4%, n = 49) (p < 0.001). The stool tests reporting time after admission was 25 (interquartile range, IQR 17–46) hours for the GI Panel, and 72 (IQR 48–96) hours for the historical cohort (p < 0.001). A significant reduction in antibiotic use was observed in the prospective cohort compared to historical cohort, 35.3% vs. 71.8%; p < 0.001), respectively. Compared to the GI Panel, norovirus ICT was only able to detect 4/11 (36.4%) patients with hospital-onset and 14/27 (51.8%) patients with community-onset diarrhea. The high positivity rate and rapid reporting time of the GI Panel had clinical benefits for children admitted for acute diarrhea, especially by reducing antibiotic use and enabling early adequate infection precaution and isolation.

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Section: Discussionmentioning

confidence: 99%

Quality Improvements in Management of Children with Acute Diarrhea Using a Multiplex-PCR-Based Gastrointestinal Pathogen Panel

et al. 2021

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“…The separation of patients is vital since they can spread the disease to others. The hospital and the wards having patients should be closed to other patients and should take a limited number of cases that can be treated with proper care, maintaining adequate distance [110]. The patients should not be treated with apathy.…”

Section: Patient Isolation and Carementioning

confidence: 99%

A Comparative Study of Challenges and Strategic Management: Lessons Learned from SARS, MERS, HIV & Ebola Outbreaks

Saraff¹,

Rishipal²,

Bhattacharyya³

et al. 2018

EAI Endorsed Transactions on Smart Cities

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INTRODUCTION: The challenges related to several viral outbreaks spanning over the centuries have exceeded human resources and capacities of the health departments to deal with the consequent adversities. Each epidemic or pandemic faced has brought out the inequalities and gaps in our systems and infrastructure. OBJECTIVES: The focus of the current paper is to do a comparative study of complex challenges faced and strategies adopted by governments during the SARS, MERS, HIV, and Ebola outbreaks. METHODS: To achieve the objective, a comprehensive summary of the challenges that the world has faced, and lessons learned from the strategic management of these viral outbreaks were analysed. CONCLUSION: An inclusive approach for the development of a multi-pronged strategic framework to benefit the concerned or affected stakeholders is discussed. These actions can guide health care workers and individuals to be aware of health hazards and complexities.

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“…Human noroviruses (HuNoVs) have been identified as the causative agents of acute gastroenteritis and are considered major pathogenic viruses that pose risks for global public health (Han et al, 2020). HuNoVs are generally transmitted through vomit-oral and/or fecal-oral routes, either by consumption of food or vegetables contaminated with human feces, or via direct person-to-person spread (Han et al, 2020). Recently, HuNoVs have been classified into 10 genogroups: HuNoV genogroup I-X (GI-X), based on the genetic differences in their capsid proteins.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical stability and virucidal effect of diluted, slightly acidic electrolyzed water against human norovirus

Lee¹,

Park²,

Yoon³

et al. 2021

Food Sci Biotechnol

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This study aimed to evaluate the virucidal effect and potential use as a disinfectant of undiluted and diluted slightly acidic electrolyzed water (SAEW) on human noroviruses (HuNoVs) using the in vitro suspension test and in food test. The oxidization reduction potential of SAEW gradually decreased with the increase in distilled water volume. Moreover, as the volume of distilled water and the dilution ratio increased, the available chlorine concentration of the samples significantly decreased from 31.2 ± 0.63 (SAEW) to 1.3 ± 0.21 (1:10 dilution of SAEW solution) (p \ 0.05). Undiluted SAEW presented the lowest pH (5.56 ± 0.02) and as SAEW was diluted in distilled water, the pH of the sample increased. Considering the standard reduction values of pathogenic virus ([ 4.00 log reduction), the reduction value of HuNoVs in cabbage samples was 4.65 (GI.6) and 4.28 (GII.4) log. These results suggest the potential application of SAEW for inactivating HuNoVs in the food industry.

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Successful control of norovirus outbreak in a pediatric ward with multi-bed rooms

Cited by 6 publications

References 23 publications

Quality Improvements in Management of Children with Acute Diarrhea Using a Multiplex-PCR-Based Gastrointestinal Pathogen Panel

Quality Improvements in Management of Children with Acute Diarrhea Using a Multiplex-PCR-Based Gastrointestinal Pathogen Panel

A Comparative Study of Challenges and Strategic Management: Lessons Learned from SARS, MERS, HIV & Ebola Outbreaks

Physicochemical stability and virucidal effect of diluted, slightly acidic electrolyzed water against human norovirus

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