Successful Conservative Management of Bilateral Renal Mucormycosis

Marsh, Benjamin M.; Rajasingham, Radha; Tawfic, Sherif; Borofsky, Michael S.

doi:10.1016/j.urology.2018.03.010

Cited by 6 publications

(5 citation statements)

References 14 publications

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“… 3 Renal mucormycosis requires nephrectomy, although report of conservative management also exists in the literature. 4 In the present study renal mucormycosis resembled emphysematous pyelonephritis in CT scan and therefore the patient did not receive timely treatment with amphotericin B in addition to nephrectomy. 5 …”

Section: Discussionmentioning

confidence: 55%

Renal mucormycosis following transurethral resection of prostate in the time of COVID-19: Unique imaging features resembling emphysematous pyelonephritis

Basiri

Mahmoudnejad

Parvin

et al. 2022

Urology Case Reports

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Section: Discussionmentioning

confidence: 55%

Renal mucormycosis following transurethral resection of prostate in the time of COVID-19: Unique imaging features resembling emphysematous pyelonephritis

Basiri

Mahmoudnejad

Parvin

et al. 2022

Urology Case Reports

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“…Em alguns pacientes, isso pode resultar em deformidades a depender a apresentação (perda da mandíbula superior e ocular em apresentação rinocerebelar) (CDC, n.d.). A abordagem com antifúngicos se mostra relevante, Mucorales é intrínsecamente resistente a alguns antifúngicos, como fluconazol, voriconazol, fluocitosina e equinocandinas, sendo a anfotericina B a terapia de escolha, sobretudo em sua forma lipossomal, em razão de nefrotoxicidade (Marsh et al, 2018). Há relatos na literatura de terapia combinada de anfotericina B com posaconazol e isavuconazol têm mostrado resultados (Mekonnen et al, 2021), no entanto com resultados questionáveis.…”

Section: Resultsunclassified

Aspergilose e mucormicose – micoses sistêmicas de importância em COVID-19: Artigo de revisão

Tavares¹,

Leite²,

Tavares

et al. 2021

RSD

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Introdução: A aspergilose invasiva e a mucormicose são infecções alarmantes em receptores de transplantes de órgãos sólidos e células hematopoiéticas. No contexto da pandemia causada pelo SARS-CoV2, têm-se evidenciados casos destas condições associadas a aumento de permanência hospitalar e desfechos sombrios. As infecções fúngicas invasivas representam entidades relevantes na atenção de pacientes graves afetados por este coronavírus. Objetivo: avaliar a importância da aspergilose e mucormicose em paciente acometidos por COVID-19. Metodologia: Trata-se de um estudo de revisão narrativa que se configura como estudo qualitativo e exploratório. Para tal, realizou-se análise de artigos publicados na base de dados PUBMED, assim como de livros impressos refrente à temática. Os termos utilizados para a pesquisa foram: “Aspergillosys”, “Mucormycosis” e “Coronavirus Infections”. Resultados: Aspergilose invasiva e mucormicose são complicações relacionadas com o aumento de mortalidade em pacientes com COVID-19. Conclusão: A aspergilose invasiva e a mucormicose são entidades com elevada mortalidade, representando efeito colateral que deve ser atentado precocemente em casos de deterioração de quadro clínico de indivíduo submetido a tratamento com corticosteroides e imunossupressores com COVID-19.

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“…The patient was successfully treated with two weeks of induction therapy with liposomal amphotericin B, followed by three months of oral posaconazole. Despite the use of amphotericin B, kidney function recovered, and dialysis was stopped [ 14 ]. Our case, therefore, represents the second reported case of bilateral IRM survival with antifungal treatment alone and the first case of successful treatment with isavuconazole.…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Bilateral Renal Mucormycosis With Isavuconazole: A Case Report

Najjar¹,

Botros²,

Acker³

et al. 2023

Cureus

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Isolated renal mucormycosis (IRM) is a rare disease with high mortality, more commonly seen in immunocompromised patients. Management has traditionally included antifungal drugs with or without nephrectomy. We present the case of a 34-year-old female with a past medical history of type 1 diabetes mellitus and intravenous heroin use who presented with fever, flank pain, hematuria, and vomiting. She was found to have an oliguric acute kidney injury (AKI) with a serum creatinine (Cr) of 2.5 mg/dL. CT showed bilateral emphysematous pyelonephritis and ureteral cultures grew Rhizopus species. Amphotericin B was started before being switched to isavuconazole due to worsening AKI, and hemodialysis was only required transiently. Rather than the traditional approach to treatment, a conservative approach that preserved kidney function was utilized, and the patient was successfully treated with six months of isavuconazole.

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Successful Conservative Management of Bilateral Renal Mucormycosis

Cited by 6 publications

References 14 publications

Renal mucormycosis following transurethral resection of prostate in the time of COVID-19: Unique imaging features resembling emphysematous pyelonephritis

Renal mucormycosis following transurethral resection of prostate in the time of COVID-19: Unique imaging features resembling emphysematous pyelonephritis

Aspergilose e mucormicose – micoses sistêmicas de importância em COVID-19: Artigo de revisão

Successful Treatment of Bilateral Renal Mucormycosis With Isavuconazole: A Case Report

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