Successful completion of an imported fire ant cluster immunotherapy protocol

Beveridge, Gloria B; Tankersley, Mike

doi:10.1016/j.anai.2019.04.017

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…Safe and effective of cluster, rush and ultra-rush schedules for fire ant immunotherapy have been previously reported. Most of the studies with a limited number of patients and the focus were mainly determined whether prophylactic pretreatment with antihistamines and steroids reduced the systemic reaction rate 14,15,16,17,18,19,20 .…”

Section: Introductionmentioning

confidence: 99%

Clinical and laboratory profile of patients with anaphylaxis to fire ant venom (Solenopsis sp) under specific subcutaneous immunotherapy

Watanabe¹,

Ferreira²,

Galvão³

et al. 2020

Preprint

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Background: Anaphylaxis to fire ant venoms (Solenopsis sp) is a significant cause of systemic reaction caused by Hymenoptera stings in children. There are only a few reports about the safety and efficacy of specific immunotherapy. Objective: Evaluate clinical characteristics, IgE and IgG4 specific responses of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp after one year of the maintenance phase. Materials and methods: Thirty-three patients were enrolled due to anaphylaxis by fire ant venom (Solenopsis sp) and underwent specific immunotherapy. They were assessed at baseline and one year after the beginning of the maintenance phase for skin test; specific venom IgE and IgG4 antibodies; tryptase. Results: All patients included presented a severe anaphylactic reaction. Although two patients (6.25%) presented a tryptase level higher than 11.4 ug/ml, systemic mastocytosis was ruled out. There was no relationship between the severity of the reaction with gender, tryptase level, atopy, previous reactions, the allergen's concentration in the skin test or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the two time points. Reactions were local, with only two mild systemic reactions during the build-up phase. Twenty patients had accidental stings during immunotherapy, with 3 presenting only urticaria. Conclusions: This study is unprecedented in evaluating clinical and laboratory data in the fire ant immunotherapy. Our results show that after one year of the maintenance phase, patients did not develop any severe reaction with only a few mild reactions and presented a significant production of specific IgG4.Clinical and laboratory profile of patients with anaphylaxis to fire ant venom (Solenopsis sp) under specific subcutaneous immunotherapy

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Section: Introductionmentioning

confidence: 99%

Clinical and laboratory profile of patients with anaphylaxis to fire ant venom (Solenopsis sp) under specific subcutaneous immunotherapy

Watanabe¹,

Ferreira²,

Galvão³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…A segurança e a eficácia de protocolos cluster, rush e ultra rush para imunoterapia com formiga de fogo foram relatados anteriormente. A maioria dos estudos tem um número limitado de pacientes e o objetivo desses estudos era determinar se o pré-tratamento profilático com anti-histamínicos e esteróides reduziriam a taxa de reação sistêmica 66,67,68,69,70,71,72 .…”

Section: Imunoterapia Alérgenos-específicaunclassified

“…Beveridge e cols. 70 descreveram um relato de caso de imunoterapia cluster em um homem de 66 anos. Dietrich e cols.…”

Section: Imunoterapia Alérgenos-específicaunclassified

Perfil clínico e laboratorial de pacientes com anafilaxia à ferroada de formigas (Solenopsis sp) sob tratamento com imunoterapia específica

Watanabe¹

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Global View on Ant Venom Allergy: from Allergenic Components to Clinical Management

Wanandy

Mulcahy

Lau

et al. 2021

Clinic Rev Allerg Immunol

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Successful completion of an imported fire ant cluster immunotherapy protocol

Cited by 4 publications

References 7 publications

Clinical and laboratory profile of patients with anaphylaxis to fire ant venom (Solenopsis sp) under specific subcutaneous immunotherapy

Clinical and laboratory profile of patients with anaphylaxis to fire ant venom (Solenopsis sp) under specific subcutaneous immunotherapy

Perfil clínico e laboratorial de pacientes com anafilaxia à ferroada de formigas (Solenopsis sp) sob tratamento com imunoterapia específica

Global View on Ant Venom Allergy: from Allergenic Components to Clinical Management

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