Successful combined antibiotic therapy with oral clindamycin and oral rifampicin for pyoderma gangrenosum in patient with PASH syndrome

Lamiaux, Marie; Dabouz, F.; Wantz, Maud; Lebas, D.; Lasek, A.; Courivaud, D.; Modiano, P.

doi:10.1016/j.jdcr.2017.05.005

Cited by 14 publications

(9 citation statements)

References 13 publications

(18 reference statements)

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“…Tetracyclines were most frequently prescribed, followed by clindamycin/rifampicin and dapsone. The known anti-inflammatory properties of certain antibiotics can account for their frequent use [68]. A promising option may be prolonged targeted antibiotic therapy using antibiotics based on microbiological culture.…”

Section: Resultsmentioning

confidence: 99%

Phenotypes and Pathophysiology of Syndromic Hidradenitis Suppurativa: Different Faces of the Same Disease? A Systematic Review

et al. 2020

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Background: There is growing evidence that (certain) hidradenitis suppurativa (HS) comorbidities comprise syndromes including HS as a key cutaneous manifestation. These apparently autoinflammatory syndromes and their diagnostic delay might have detrimental effects on affected patients. Methods: A systematic review was performed on the databases MEDLINE, EMBASE, and CENTRAL utilizing a standardized extraction form according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: Sixty-four eligible articles on syndromic HS were retrieved. The identified syndromes included already described ones (pyoderma gangrenosum-acne-suppurative hidradenitis, pyogenic arthritis-pyoderma gangrenosum-acne-suppurative hidradenitis, psoriatic arthritis-pyoderma gangrenosum-acne-suppurative hidradenitis, pyoderma gangrenosum-acne vulgaris-hidradenitis suppurativa-ankylosing spondylitis, synovitis-acne-pustulosis-hyperostosis-osteitis) and further novel symptom constellations. Cutaneous signs, including HS lesions, usually precede signs from other organs. The cutaneous signs of a considerable proportion of patients appear refractory to conventional treatment, and monotherapy with biologics does not suffice to sustain remission. Conclusion: The results are subsequently discussed with focus on the pathophysiology and treatment of the detected syndromes. The dermatologist’s role in the precise diagnosis and early treatment administration of HS is pivotal. The purpose of the treatment should be the effective prevention or delay of the autoinflammatory march and its irreversible consequences.

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Section: Resultsmentioning

confidence: 99%

Phenotypes and Pathophysiology of Syndromic Hidradenitis Suppurativa: Different Faces of the Same Disease? A Systematic Review

et al. 2020

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“…A total of 3212 unique citations were found. 1286 and 1704 citations were excluded by abstract and full‐text read, respectively, yielding 222 articles…”

Section: Resultsmentioning

confidence: 99%

Pyoderma gangrenosum and tumour necrosis factor alpha inhibitors: A semi‐systematic review

Abdallah

Fogh

Bech

2019

International Wound Journal

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Pyoderma gangrenosum (PG) is a rare ulcerative skin disease that presents a therapeutic challenge. Tumour necrosis factor alpha (TNFα) inhibitors have been reported to successfully control PG. Our aim was to systematically evaluate and compare the clinical effectiveness of TNFα inhibitors in adults with PG. A literature search including databases such as PubMed, Embase, Scopus, and Web of Science was conducted, using search terms related to PG and TNFα inhibitors. Studies and case reports were included if patients were diagnosed with PG, over the age of 18 and administered TNFα inhibitor. A total of 3212 unique citations were identified resulting in 222 articles describing 356 patients being included in our study. The study we report found an 87% (95% CI: 83%‐90%) response rate and a 67% (95% CI: 62%‐72%) complete response rate to TNFα inhibitors. No statistically significant differences in the response rates (P = 0.6159) or complete response rates (P = 0.0773) to infliximab, adalimumab, and etanercept were found. In our study TNFα inhibitors demonstrated significant effectiveness with response and complete response rates supporting the use of TNFα inhibitors to treat PG in adults. Our study suggests that there is no significant difference in effectiveness among infliximab, adalimumab, and etanercept.

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“…Pyoderma gangrenosum may even respond to antibacterial drugs with an immunomodulatory effect, such as rifampicin. 6 Once the diagnosis of perianal TB has been established, a thorough search for the origin and the involvement of other sites in the body in TB should be undertaken. 14 In addition to chest radiography and CT scans, patients should also be evaluated with a barium enema, ultrasound, CT and magnetic resonance imaging of the abdomen, and colonoscopy to identify possible gastrointestinal and peritoneal involvement.…”

Section: Discussionmentioning

confidence: 99%

Primary extensive perianal cutaneous tuberculosis: A challenging diagnosis. Case report and a review of the literature

Takahashi¹,

Bassaneze²,

Longo³

et al. 2023

The Brazilian Journal of Infectious Diseases

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Successful combined antibiotic therapy with oral clindamycin and oral rifampicin for pyoderma gangrenosum in patient with PASH syndrome

Cited by 14 publications

References 13 publications

Phenotypes and Pathophysiology of Syndromic Hidradenitis Suppurativa: Different Faces of the Same Disease? A Systematic Review

Phenotypes and Pathophysiology of Syndromic Hidradenitis Suppurativa: Different Faces of the Same Disease? A Systematic Review

Pyoderma gangrenosum and tumour necrosis factor alpha inhibitors: A semi‐systematic review

Primary extensive perianal cutaneous tuberculosis: A challenging diagnosis. Case report and a review of the literature

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