Successful Colonoscopic Approach in Aa Child with Intussusception Associated with Enterohemorrhagic Escherichia coli O157 Infection

Hagiwara, Shin-ichiro; Tobayama, Hisako; Kagimoto, Seiichi

doi:10.4081/pr.2012.e33

Cited by 2 publications

(1 citation statement)

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“…EHEC infections of humans start with watery and bloody diarrhea upon colonization, may be involved in bowel necrosis, colonic perforation, and intussusceptions and can manifest as serious hemorrhagic colitis [92,[148][149][150][151][152]. The hallmark of hemorrhagic colitis due to EHEC is the development of bloody diarrhea several days after the onset of non-bloody diarrhea and abdominal pain.…”

Section: Ehec-caused Systemic Complicationsmentioning

confidence: 99%

Enterohemorrhagic Escherichia coli and a Fresh View on Shiga Toxin-Binding Glycosphingolipids of Primary Human Kidney and Colon Epithelial Cells and Their Toxin Susceptibility

Detzner

Pohlentz

Müthing

2022

IJMS

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Enterohemorrhagic Escherichia coli (EHEC) are the human pathogenic subset of Shiga toxin (Stx)-producing E. coli (STEC). EHEC are responsible for severe colon infections associated with life-threatening extraintestinal complications such as the hemolytic-uremic syndrome (HUS) and neurological disturbances. Endothelial cells in various human organs are renowned targets of Stx, whereas the role of epithelial cells of colon and kidneys in the infection process has been and is still a matter of debate. This review shortly addresses the clinical impact of EHEC infections, novel aspects of vesicular package of Stx in the intestine and the blood stream as well as Stx-mediated extraintestinal complications and therapeutic options. Here follows a compilation of the Stx-binding glycosphingolipids (GSLs), globotriaosylceramide (Gb3Cer) and globotetraosylceramide (Gb4Cer) and their various lipoforms present in primary human kidney and colon epithelial cells and their distribution in lipid raft-analog membrane preparations. The last issues are the high and extremely low susceptibility of primary renal and colonic epithelial cells, respectively, suggesting a large resilience of the intestinal epithelium against the human-pathogenic Stx1a- and Stx2a-subtypes due to the low content of the high-affinity Stx-receptor Gb3Cer in colon epithelial cells. The review closes with a brief outlook on future challenges of Stx research.

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